Effective treatment of urinalysis: A Synthesis of Findings from 101 Studies

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Original Abstract of the Article

Major Research Findings

Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Corticosteroids and 5-aminosalicylates are the most commonly used therapies. However, many patients require immunosuppressive therapy for steroid-refractory and steroid-dependent disease. Methotrexate is a medication that is effective for treating a variety of inflammatory diseases, including Crohn's disease. This review was performed to determine the effectiveness of methotrexate treatment in UC patients. This review is an update of a previously published Cochrane review. 57

Sulphasalazine retention enemas have been shown to be effective in the treatment of UC. This medication may be particularly effective for patients who experience side effects when taking the medication orally, such as nausea, abdominal discomfort, or headaches. 8

Patients with ulcerative colitis may require colectomy for severe disease unresponsive or refractory to pharmacological therapy. Managing ulcerative colitis is complicated because there are many factors at play, including patient optimization and treatment, as the guidance varies on the ideal perioperative use of corticosteroids, immunomodulators, biologics, and small molecule agents. 94

TNF-α plays an important role in the pathogenesis of ulcerative colitis (UC). Anti-TNF-α therapy appears to be beneficial in the treatment of UC. The aim of this study was to assess the effectiveness of Infliximab and Adalimamab in UC compared with conventional therapy. 61

Despite recent advances in the medical treatment of ulcerative colitis (UC), approximately 25-40% of patients will need surgery during their disease. The aim of elective surgical treatment of UC is to remove the colon/and rectum with minimal postoperative morbidity, and to offer a good long-term quality of life. There are several technical options for the surgical treatment of UC; at present, the most frequently offered is restorative proctocolectomy and ileal pouch-anal anastomosis. Both the surgeon and patient should be aware of the risks associated with a technically demanding procedure and possible postoperative complications, including the possibility of infertility, permanent stoma, or several surgical procedures for pouch-related complications. A precise knowledge of each surgical technique, and its indications, complications, long-term risks and benefits is useful to offer the best surgical option tailored to each patient. 51

Curcumin, an active ingredient of turmeric, has been studied in the past and found to be useful in the treatment of UC when used as an adjuvant along with mesalamine. 74

Corticosteroids such as prednisolone are used to treat severe UC. Corticosteroids are effective in about 60% of patients with severe UC, but the remaining patients require other treatments, such as surgery. 10

Mesalazine is the first-line medication for the treatment of mild-to-moderately active ulcerative colitis (UC). However, multiple-dosing regimens are inconvenient for patients. 52

Infliximab has proven efficacious in the treatment of Crohn's disease. Limited and contrasting data are available on effectiveness of anti-TNF alpha therapy in ulcerative colitis. We evaluated the efficacy of infliximab in the management of steroid-dependent ulcerative colitis. 24

Oral and topical mesalazine formulations are effective in active ulcerative colitis, but little is known on the efficacy of combined treatment. 18

The role of antibiotics in the treatment of ulcerative colitis is controversial. This study aims at assessing the therapeutic role of ciprofloxacin as an adjunct to corticosteroids in acute severe ulcerative colitis. 19

To investigate the value of combined treatment with allopurinol and 5-aminosalicylic (5-ASA) based drugs as maintenance treatment for ulcerative colitis (UC). 17

Leukocytapheresis (LAP) could be an alternative treatment for steroid-dependent ulcerative colitis (UC). 39

Intravenous steroid therapy is the standard treatment in severe attacks of ulcerative colitis (UC), but 20% to 60% of patients fail to respond and require colectomy. Cyclosporine (CyA) has shown efficacy in steroid failures and could avoid surgery, but controversy remains. 29

Probiotics are effective in inflammatory bowel diseases. Clinical effectiveness and dose dependency of E. coli Nissle (EcN) enemas were investigated in ulcerative colitis (UC). 43

Aminosalicylates are the most frequently prescribed treatment for ulcerative colitis (UC). In the absence of empirical evidence, clinicians are uncertain whether to continue aminosalicylates in patients with UC after escalating therapy. 76

In recent years, the therapeutic goals in ulcerative colitis (UC) have become increasingly stringent. Histological features seem to be a reliable predictor of disease outcomes after therapy, and histological remission (HR) is the new frontier in the treatment of UC. Here, we first provide a historical perspective before reviewing indexes in the era of biologics; histology as a treatment goal in UC trials; the poor correlation between symptoms, endoscopy, and histology; and the impact of histology on disease outcomes. HR seems to be a promising end point for the treatment of UC because it is typically associated with better outcomes. Two new validated indexes are available to assess histology more accurately in trials, and they may also be applicable to clinical practice. Additional interventional trials are now necessary to establish definitions of HR and its potential for disease modification. 81

Biological agents are emerging treatment options for the management of ulcerative colitis (UC). 54

Ulcerative colitis (UC) is characterized by a life-long chronic course with remissions and exacerbations. Approximately 15% of patients have a severe attack requiring hospitalization at some time during their illness. These patients are traditionally treated with intravenous corticosteroids, with a response rate of approximately 60%. The patients who do not respond to steroid treatment usually require surgical removal of the large bowel (proctocolectomy or colectomy with an anal pouch). This surgical procedure essentially cures the patient from the disease but is associated with complications such as pouchitis. Few alternative treatments exist for severe ulcerative colitis: immunosuppressive medications (such as azathioprine) have a slow onset of action and are therefore usually ineffective. Antibiotics are not proven to be effective and biological treatments such as infliximab are still under investigation. The introduction of cyclosporine-A (CsA) for use in patients with severe ulcerative colitis (UC) has provided an alternative to patients previously facing only surgical options. Cyclosporine acts mainly by inhibiting T lymphocyte function, which is essential for the propagation of inflammation. Unlike most other immunosuppressive agents, CsA does not suppress the activity of other hematopoietic cells, does not cause bone marrow suppression and has a rapid onset of action. This reviews aims to systematically assess the effectiveness and safety of CsA for severe UC. 25

Ulcerative colitis (UC) is a chronic disease affecting the large intestine. Cytokines, as inflammatory mediators, can enable pathological injury of the intestinal mucosa and play an important role in UC's pathogenesis. Traditional Chinese medicine (TCM) offers a wealth of theory and experience in UC's treatment. 99

Management of Crohn's disease and ulcerative colitis has typically relied upon treatment intensification driven by symptoms alone. However, a 'treat-to-target' management approach may help to address underlying inflammation, minimise disease activity at early stages of inflammatory bowel disease, limit progression, and improve long-term outcomes. 79

Unspecified Ulcerative Rectocolitis is a chronic disease that affects between 0.5 and 24.5/105 inhabitants in the world. National and international clinical guidelines recommend the use of aminosalicylates (including mesalazine) as first-line therapy for induction of remission of unspecified ulcerative rectocolitis, and recommend the maintenance of these agents after remission is achieved. However, multiple daily doses required for the maintenance of disease remission compromise compliance with treatment, which is very low (between 45% and 65%). Use of mesalazina in granules (2 g sachet) once daily--Pentasa® sachets 2 g--can enhance treatment adherence, reflecting in an improvement in patients' outcomes. 53

Ulcerative colitis has been suggested to be caused by infection and there is circumstantial evidence linking Escherichia coli with the condition. Our aim was to find out whether the administration of a non-pathogenic strain of E. coli (Nissle 1917) was as effective as mesalazine in preventing relapse of ulcerative colitis. We also examined whether the addition of E. coli to standard medical therapy increased the chance of remission of active ulcerative colitis. 14

Treatment Summary

Methotrexate is a medication that is effective for treating a variety of inflammatory diseases, including Crohn's disease. This review was performed to determine the effectiveness of methotrexate treatment in UC patients. This review is an update of a previously published Cochrane review. 57 Sulphasalazine retention enemas have been shown to be effective in the treatment of UC. This medication may be particularly effective for patients who experience side effects when taking the medication orally, such as nausea, abdominal discomfort, or headaches. 8 Anti-TNF-α therapy appears to be beneficial in the treatment of UC. 61 Curcumin, an active ingredient of turmeric, has been studied in the past and found to be useful in the treatment of UC when used as an adjuvant along with mesalamine. 74 Corticosteroids such as prednisolone are used to treat severe UC. 10 Mesalazine is the first-line medication for the treatment of mild-to-moderately active ulcerative colitis (UC). 52 Infliximab has proven efficacious in the treatment of Crohn's disease. 24 Cyclosporine has shown efficacy in steroid failures and could avoid surgery, but controversy remains. 29 Probiotics are effective in inflammatory bowel diseases. 43 Biological agents are emerging treatment options for the management of ulcerative colitis (UC). 54

Benefits and Risks

Benefits Summary

There are a variety of treatments for UC, including methotrexate, sulphasalazine retention enemas, anti-TNF-α therapy, curcumin, corticosteroids, mesalazine, infliximab, cyclosporine, probiotics, and biological agents. These treatments may help improve UC symptoms, slow disease progression, and maintain remission. 57 8 61 74 10 52 24 29 43 54

Risks Summary

UC treatments carry a risk of side effects. Methotrexate can increase the risk of liver damage and infections. 57 Sulphasalazine retention enemas can cause side effects such as headaches, nausea, and abdominal pain. 8 Anti-TNF-α therapy can increase the risk of infections. 61 Corticosteroids can cause side effects such as weight gain, high blood sugar, and osteoporosis. 10 Infliximab can increase the risk of infections. 24 Cyclosporine can increase the risk of kidney damage, high blood pressure, and infections. 29 Biological agents can increase the risk of infections. 54

Comparison of Research

Commonalities in Research

These studies are all research on the treatment of UC, but each study focuses on a different treatment, so there are few commonalities.

Differences in Research

These studies differ in the treatments they focus on, their research design, and the evaluation criteria they use. As a result, their findings cannot be directly compared.

Consistency and Contradictions in Findings

These studies demonstrate that there are various options for treating UC. However, there are still many unknowns regarding the effectiveness and safety of each treatment, and further research is necessary.

Considerations for Real-World Applications

The treatment for UC should be determined in consultation with a physician, considering various factors such as the patient's symptoms, medical condition, age, and past treatment history. Do not change or start new treatments without a physician's guidance.

Limitations of Current Research

These studies were all conducted using different research designs and evaluation criteria. Therefore, it is difficult to directly compare their findings. Also, some studies had small sample sizes, so generalizing the findings needs to be done with caution.

Future Research Directions

To assess the effectiveness and safety of UC treatment methods in greater detail, larger, long-term, multi-center studies are needed. The combined effects of different treatment methods, as well as their relationship to the patient's genetic factors, need to be investigated further.

Conclusion

There are various options for treating UC; however, there are still many unknowns regarding the effectiveness and safety of each treatment, and further research is necessary. It is important to choose the best treatment option in consultation with a physician when receiving treatment for UC.

List of Treatments

Methotrexate, sulphasalazine retention enemas, anti-TNF-α therapy, curcumin, corticosteroids, mesalazine, infliximab, cyclosporine, probiotics, biological agents

Keywords
Benefit Keywords
Ulcerative colitis treatment
1
Therapeutic success
3
Few side effects
Improved disease course
7
Sulphasalazine effective
Ulcerative colitis treatment
8
Improved ulcerative colitis symptoms
9
Effective treatment
10
Ulcerative colitis treatment
11
Improved ulcerative colitis treatment
12
Nocturnal symptom control
UC remission
13
Improved ulcerative colitis treatment
14
Improved ulcerative colitis treatment
15
Improved colitis remission
Improved colitis symptoms
Reduced patient costs
16
Ulcerative colitis remission
17
Treat ulcerative colitis
18
Remission of colitis
20
Ulcerative colitis remission
21
Effective treatment of distal ulcerative colitis
22
Ulcerative colitis treatment
23
Remission induction
Steroid withdrawal
24
Rapid onset of action
Severe UC treatment
25
Safe treatment
UC symptom relief
26
Ulcerative colitis treatment
27
Avoid colectomy
UC remission
29
Improved UC
Reduced prednisolone
30
Clinical remission
31
Improved ulcerative colitis treatment
32
Steroid withdrawal
33
Ulcerative colitis treatment
34
Short-term clinical improvement
35
Fewer side effects
Superior treatment
36
Improved QOL
37
Reduced colectomy
Reduced hospitalizations
Reduced surgeries
38
Sustained Remission
39
Ulcerative colitis treatment
40
Maintained UC remission
41
Improved UC remission
42
E. coli Nissle effective
43
Higher remission rate
Improved endoscopic and histological remission rates
44
Pediatric UC treatment
45
Improved UC-DAI score
46
Induced remission
Prevented relapse
47
Treatment of ulcerative colitis
48
Treatment of ulcerative colitis
49
Improved IBD treatment
50
Treatment of UC
51
Improved ulcerative colitis symptoms
52
Improved outcomes
Mesalazine granules
53
Effective treatment for UC
54
EcN treatment
55
5-ASA
Anti-TNF-α agents
Corticosteroids
Thiopurines
56
Methotrexate
57
Diosmectite + mesalazine UC
58
Improved CD symptoms
59
IBD treatment
60
Improved clinical remission
Improved clinical response
61
Effective for UC
63
UC treatment
64
Disease control
65
MG for UC
66
Improved clinical remission
67
FMT effective
FMT safe
68
UC treatment
69
Safe alternative
70
Effective UC induction treatment
Improved maintenance UC treatment
Improved mucosal healing
71
Remission induction
72
Improved UC treatment
73
Improved UC treatment
74
Fewer adverse events
No significant difference in remission
75
Improved IBD treatment
77
Improved UC activity
Improved food tolerance
Improved histological findings
78
Crohn's disease and ulcerative colitis treatment
Treat-to-target management
79
Improved UC treatment
80
Improved UC treatment
81
Efficacious treatment
Safe treatment
82
Ulcerative colitis treatment
83
Ulcerative colitis treatment
84
Ulcerative colitis treatment
85
ESD
UC patients
colonic lesions
86
Reduced ulcerative colitis activity
87
Ulcerative colitis treatment
88
Clinical remission
Reduced progression
Reduced recurrence
89
Rapid symptom relief
91
Probiotic treatment for IBD
92
Ulcerative colitis remission
93
Ulcerative colitis management
94
IBD treatment
95
Ulcerative colitis treatment
96
Ulcerative colitis treatment
97
Endoscopic improvement
Histological improvement
UC remission
98
UC treatment
99
UP remission
100
UC treatment
101
Risk Keywords
Ineffective treatment
2
Higher colectomy rate
Prolonging therapy not effective
3
Bowel rest ineffective
4
Levamisole ineffective
5
Not dramatically successful
7
Headache
Lightheadedness
Nausea
Sleep disturbance
9
Side effects
10
Adverse events
Serious adverse events
Withdrawal due to adverse events
13
No augmented effect
19
Relapse
24
Complications of proctocolectomy or colectomy with an anal pouch
25
Abdominal pain
28
Death
Minor side effects
Severe infections
29
Finger tremor
Side effects
30
Steroid-related adverse reactions
31
Ulcerative colitis
32
Bloating
33
Adverse events
Finger tremor
Gastroenteritis
Headache
Hot flush
Queasiness
Sepsis
Sleepiness
Stomach discomfort
35
Malignancy
Serious infections
Tuberculosis
38
Postoperative complications
40
Infertility
Permanent stoma
51
Low compliance
Ulcerative rectocolitis
53
Ulcerative colitis
55
Ulcerative proctitis
56
Ulcerative colitis
57
UC relapse rate
58
Adverse events
Discontinuation
59
Colectomy rate
61
Treatment failure
62
None mentioned
63
IPAA
Ileostomy
65
Adverse events
Ineffective for steroid-free remission
67
Poor tolerability
70
Need for further trials
75
Adverse events
82
bleeding
perforation
86
Adverse events
89
Eosinophils in UC
90
Adverse events
93
Adverse events
98
Literature analysis of 101 papers
Positive Content
94
Neutral Content
1
Negative Content
6
Article Type
52
31
43
26
101
1.

Is topical therapy necessary in acute distal colitis? Double-blind comparison of high-dose oral mesalazine versus steroid enemas in the treatment of active distal ulcerative colitis.

Author: CobdenI, al-MardiniH, ZaitounA, RecordC O

Ulcerative colitis treatment

A study of 37 patients with acute distal ulcerative colitis found that both oral mesalazine and steroid enemas were effective in reducing symptoms, with no significant difference between the treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

A comparative study of metronidazole and sulfasalazine in active, not severe, ulcerative colitis. An Israeli multicenter trial.

Author: GilatT, SuissaA, LeichtmanG, DelpreG, PavlotzkyM, GrossmanA, FiremanZ

Ineffective treatment

This study compared the effectiveness of metronidazole (M) and sulfasalazine (S) in treating 42 patients with acute, non-severe ulcerative colitis (UC). After 28 days of treatment, 26% of patients receiving metronidazole improved, compared to 68% of patients receiving sulfasalazine. The study concludes that metronidazole is not an effective treatment for acute ulcerative colitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Predicting the outcome of corticoid therapy for acute ulcerative colitis. Results of a prospective, randomized, double-blind clinical trial.

Author: MeyersS, LererP K, FeuerE J, JohnsonJ W, JanowitzH D

Therapeutic success
Higher colectomy rate
Prolonging therapy not effective

This study examined factors predicting the success of corticosteroid treatment for 66 patients with severe ulcerative colitis. 42% of patients achieved remission within 10 days of treatment. Factors associated with successful treatment included less severe disease activity, such as the absence of fulminant colitis, limited disease extent, shorter duration of symptoms, fewer stools, lower erythrocyte sedimentation rate, and higher hemoglobin. Early remission was also associated with a more favorable long-term outcome. Prolonging treatment beyond 10 days did not improve remission rates and may have increased the risk of needing surgery. The study concludes that early remission during the initial 10-day treatment period is the most important factor predicting a positive outcome for patients with severe ulcerative colitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Controlled trial of bowel rest in the treatment of severe acute colitis.

Author: McIntyreP B, Powell-TuckJ, WoodS R, Lennard-JonesJ E, LereboursE, HecketsweilerP, GalmicheJ P, ColinR

Bowel rest ineffective

A study of 47 patients with severe, acute, non-infective colitis found that bowel rest did not improve outcomes for patients treated with intravenous prednisolone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The effect of levamisole on the maintenance of remission of ulcerative colitis. A 2-year double-blind study.

Author: HermanowiczA, SliwińskiZ, NowakA, GajosL

Levamisole ineffective

This study investigated the effectiveness of levamisole in treating 50 patients with ulcerative colitis. The study found that levamisole was not effective in treating ulcerative colitis. The study concludes that only drugs that suppress both the immune system's natural response and its acquired response to specific antigens are effective in treating ulcerative colitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Azathioprine in ulcerative colitis: final report on controlled therapeutic trial.

Author: JewellD P, TrueloveS C

A study of 80 patients with ulcerative colitis found that adding azathioprine to standard corticosteroid treatment did not improve outcomes during an acute attack. While azathioprine did not benefit patients experiencing their first attack, it showed potential benefit in preventing relapses in patients with established disease. However, this difference did not reach statistical significance. The study suggests that azathioprine may have a role in managing ulcerative colitis, particularly for those with recurring disease, but further research is needed to confirm its effectiveness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Azathioprine in ulcerative colitis: an interim report on a controlled therapeutic trial.

Author: JewellD P, TrueloveS C

Few side effects
Improved disease course
Not dramatically successful

A study of 40 patients with ulcerative colitis found that azathioprine, when added to standard corticosteroid treatment, may help prevent relapses over a one-year period. After initial treatment, 11 out of 20 patients taking azathioprine remained symptom-free compared to only 5 out of 20 in the control group. While this difference was not statistically significant, it suggests that azathioprine may be beneficial for managing ulcerative colitis, especially when conventional treatments are ineffective or surgery is not desired. The study found that azathioprine was well tolerated, with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Sulphasalazine retention enemas in ulcerative colitis: a double-blind trial.

Author: PalmerK R, GoepelJ R, HoldsworthC D

Sulphasalazine effective
Ulcerative colitis treatment

A study of 34 patients with ulcerative colitis compared the effectiveness of sulphasalazine enemas to placebo. Sulphasalazine enemas significantly improved symptoms in patients who were not already taking oral sulphasalazine. Eleven out of 16 patients receiving sulphasalazine enemas improved compared to only 2 out of 18 receiving placebo. The treatment was well-tolerated, with no side effects observed, even in patients who previously experienced side effects from oral sulphasalazine. The study suggests that sulphasalazine enemas may be a good treatment option for patients who cannot tolerate oral sulphasalazine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Transdermal nicotine for active ulcerative colitis.

Author: PullanR D, RhodesJ, GaneshS, ManiV, MorrisJ S, WilliamsG T, NewcombeR G, RussellM A, FeyerabendC, ThomasG A

Improved ulcerative colitis symptoms
Headache
Lightheadedness
Nausea
Sleep disturbance

Transdermal nicotine improved symptoms in patients with ulcerative colitis compared with placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Corticosteroids for the management of ulcerative colitis.

Author: OshitaniN, KitanoA, MatsumotoT, KobayashiK

Effective treatment
Side effects

Two studies investigated the effectiveness of different prednisolone dosages and megadose pulsed steroid therapy for ulcerative colitis. In the first study, 24 patients with severe ulcerative colitis were randomly assigned to receive either 1.0 mg/kg or 1.5 mg/kg of prednisolone daily. While there were no significant differences in overall improvement between the groups, the 1.5 mg/kg dosage was more effective in patients experiencing their first attack. The second study involved 13 patients with severe or moderately severe ulcerative colitis receiving megadose pulsed steroid therapy. Ten patients achieved clinical remission, one improved, and two did not respond. Endoscopically, five achieved remission, six improved, and two did not respond. No serious adverse effects or steroid withdrawal syndrome were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis.

Author: KruisW, SchützE, FricP, FixaB, JudmaierG, StolteM

Ulcerative colitis treatment

This study investigated the potential benefits of probiotic treatment with an oral preparation of non-pathogenic E. coli in maintaining remission in ulcerative colitis, a condition currently treated with aminosalicylates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Long-term treatment of ulcerative colitis with ciprofloxacin: a prospective, double-blind, placebo-controlled study.

Author: TurunenU M, FärkkiläM A, HakalaK, SeppäläK, SivonenA, OgrenM, VuoristoM, ValtonenV V, MiettinenT A

Improved ulcerative colitis treatment

This study investigated the effectiveness of ciprofloxacin in treating ulcerative colitis, a chronic inflammatory bowel disease. While gut bacteria are thought to play a role in the development of ulcerative colitis, antibiotics are not currently a standard treatment. This study focused on patients whose symptoms were not adequately controlled by conventional medications like steroids and mesalamine, examining whether ciprofloxacin could help induce and maintain remission in these individuals.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Maintenance of remission of ulcerative colitis: a comparison between balsalazide 3 g daily and mesalazine 1.2 g daily over 12 months. ABACUS Investigator group.

Author: GreenJ R, GibsonJ A, KerrG D, SwarbrickE T, LoboA J, HoldsworthC D, CroweJ P, SchofieldK J, TaylorM D

Nocturnal symptom control
UC remission
Adverse events
Serious adverse events
Withdrawal due to adverse events

Balsalazide was more effective than mesalazine in preventing relapses and controlling nocturnal symptoms in patients with ulcerative colitis in remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial.

Author: RembackenB J, SnellingA M, HawkeyP M, ChalmersD M, AxonA T

Improved ulcerative colitis treatment

This study investigated whether a non-pathogenic strain of E. coli (Nissle 1917) could be as effective as mesalazine in preventing relapses of ulcerative colitis. The study also examined if adding this E. coli strain to standard treatment could increase the chances of remission in patients with active ulcerative colitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Mycophenolate mofetil versus azathioprine in patients with chronic active ulcerative colitis: a 12-month pilot study.

Author: OrthT, PetersM, SchlaakJ F, KrummenauerF, WanitschkeR, MayetW J, GalleP R, NeurathM F

Improved ulcerative colitis treatment

This study compared the effectiveness and safety of mycophenolate mofetil (MMF) with prednisolone to azathioprine (AZA) with prednisolone for treating chronic active ulcerative colitis (UC). Both AZA and MMF are immunosuppressants used for UC, but there are limited alternative treatments available. The study aimed to determine which combination was more beneficial for patients with UC.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis.

Author: CohenR D, WosethD M, ThistedR A, HanauerS B

Improved colitis remission
Improved colitis symptoms
Reduced patient costs

Topical mesalamine is more effective than oral therapies and topical steroids for left-sided ulcerative colitis and ulcerative proctitis. It also has a favorable side-effect profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Allopurinol in addition to 5-aminosalicylic acid based drugs for the maintenance treatment of ulcerative colitis.

Author: JärnerotG, StrömM, DanielssonA, KilanderA, LööfL, HultcrantzR, LöfbergR, FlorénC, NilssonA, BroströmO

Ulcerative colitis remission

Combined treatment with allopurinol and 5-aminosalicylic (5-ASA) based drugs may be more effective than 5-ASA alone in maintaining remission in ulcerative colitis (UC) patients. In a study of 199 patients, allopurinol group had a higher remission rate at 6 months (77% vs 59%). However, this difference was not observed at 12 months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Oral versus combination mesalazine therapy in active ulcerative colitis: a double-blind, double-dummy, randomized multicentre study.

Author: VecchiM, MeucciG, GionchettiP, BeltramiM, Di MaurizioP, BerettaL, GanioE, UsaiP, CampieriM, FornaciariG, de FranchisR

Treat ulcerative colitis

Oral mesalazine was as effective as combined oral and topical mesalazine in inducing remission in patients with mildly to moderately active ulcerative colitis. A randomized controlled trial involving 130 patients found that both treatments led to a similar rate of clinical remission at 6 weeks, with no significant difference in time to remission or rate of endoscopic remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

A prospective randomized controlled trial of intravenous ciprofloxacin as an adjunct to corticosteroids in acute, severe ulcerative colitis.

Author: MantzarisG J, PetrakiK, ArchavlisE, AmberiadisP, KourtessasD, ChristidouA, TriantafyllouG

No augmented effect

A short course of intravenous ciprofloxacin did not augment the effect of corticosteroids for patients with acute, severe ulcerative colitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Distal ulcerative colitis refractory to rectal mesalamine: role of transdermal nicotine versus oral mesalamine.

Author: GuslandiMario, FregoRoberto, VialeEdi, TestoniPier Alberto

Remission of colitis

This study evaluated the possible therapeutic benefit of transdermal nicotine versus oral mesalamine in 30 patients with left-sided ulcerative colitis unresponsive to treatment with a mesalamine 4 g enema at bedtime. Remission was observed in 12 of 15 patients receiving additional treatment with nicotine and in five of 15 patients receiving additional treatment with oral mesalamine (P=0.027). The addition of transdermal nicotine to treatment with mesalamine enemas is significantly superior to combined therapy with oral and rectal mesalamine in patients with distal ulcerative colitis refractory to rectal mesalamine alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Oral and topical 5-aminosalicylic acid (mesalazine) in inducing and maintaining remission in mild-moderate relapse of ulcerative colitis: one-year randomised multicentre trial.

Author: PaoluziP, D'AlbasioG, PeraA, Bianchi PorroG, PaoluziO A, PicaR, CottoneM, MiglioliM, PranteraC, SturnioloG, ArdizzoneS

Ulcerative colitis remission

An additional 4 weeks of topical treatment with 5-aminosalicylic acid did not increase the remission rate in patients with mild-moderate active ulcerative colitis, but it may reduce the probability of relapse in patients with left-sided colitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial.

Author: VerniaP, AnneseV, BresciG, d'AlbasioG, D'IncàR, GiaccariS, IngrossoM, MansiC, RieglerG, ValpianiD, CaprilliR,

Effective treatment of distal ulcerative colitis

This study aimed to confirm the effectiveness of topical butyrate and 5-ASA in treating ulcerative colitis affecting the lower part of the colon that does not respond to standard treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Infliximab for acute, not steroid-refractory ulcerative colitis: a randomized pilot study.

Author: OchsenkühnThomas, SackmannMichael, GökeBurkhard

Ulcerative colitis treatment

This study explores the effectiveness of infliximab, a medication that targets a protein involved in inflammation, in treating patients with acute ulcerative colitis (inflammation of the colon) who are unable to take steroids. The study aims to determine if infliximab can help these patients achieve remission, even without needing steroid treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Infliximab in the treatment of steroid-dependent ulcerative colitis.

Author: ArmuzziA, De PascalisB, LupascuA, FedeliP, LeoD, MentellaM C, VincentiF, MelinaD, GasbarriniG, PolaP, GasbarriniA

Remission induction
Steroid withdrawal
Relapse

Infliximab appears to be as effective as steroids in the management of moderate to severe steroid-dependent ulcerative colitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Topical treatment of distal active ulcerative colitis with beclomethasone dipropionate or mesalamine: a single-blind randomized controlled trial.

Author: GionchettiPaolo, D'ArienzoAgesilao, RizzelloFernando, MangusoFrancesco, MaieronRoberto, LecisPier Enrico, ValpianiDaniela, IaquintoGaetano, AnneseVito, BalzanoAntonio, VaroliGuido, CampieriMassimo,

Safe treatment
UC symptom relief

Beclomethasone dipropionate (BDP) administered as a rectal enema was efficacious and safe in patients with active ulcerative colitis (UC), without interfering with pituitary adrenal axis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Combined oral and enema treatment with Pentasa (mesalazine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: a randomised, double blind, placebo controlled study.

Author: MarteauP, ProbertC S, LindgrenS, GassulM, TanT G, DignassA, BefritsR, MidhagenG, RademakerJ, FoldagerM

Ulcerative colitis treatment

This study investigated whether adding a mesalazine enema to oral mesalazine medication provides additional benefits for patients with mild to moderate ulcerative colitis (UC) that affects a large part of the colon. The study focused on this specific group because most symptoms are related to the lower portion of the colon.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

A randomized trial of nicotine enemas for active ulcerative colitis.

Author: IngramJohn R, ThomasGareth A O, RhodesJohn, GreenJohn T, HawkesNeil D, SwiftJill L, SrivastavaEmmanuel D, EvansBrian K, WilliamsGeraint T, NewcombeRobert G, CourtneyEdward, PillaiSuresh

Abdominal pain

Six-milligram nicotine enemas were well tolerated but were not found to be efficacious for active ulcerative colitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Cyclosporine in the treatment of severe attack of ulcerative colitis: a systematic review.

Author: García-LópezS, Gomollón-GarcíaF, Pérez-GisbertJ

Avoid colectomy
UC remission
Death
Minor side effects
Severe infections

Cyclosporine (intravenous, 2 mg/kg/day) constitutes an efficacious and relatively safe alternative in the treatment of severe, steroid-refractory, attack of UC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis.

Author: OgataH, MatsuiT, NakamuraM, IidaM, TakazoeM, SuzukiY, HibiT

Improved UC
Reduced prednisolone
Finger tremor
Side effects

Oral tacrolimus was effective and safe for remission-induction therapy of refractory UC. The optimal target range appears to be 10-15 ng/ml in terms of efficacy with two week therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Continuous infusion versus bolus administration of steroids in severe attacks of ulcerative colitis: a randomized, double-blind trial.

Author: BossaFabrizio, FiorellaSerafina, CarusoNazario, AccadiaLaura, NapolitanoGrazia, ValvanoMaria Rosa, AndriulliAngelo, AnneseVito

Clinical remission
Steroid-related adverse reactions

Methylprednisolone given as a continuous infusion was no better than bolus administration in terms of efficacy and safety in patients with severe attacks of ulcerative colitis. Previous use of steroids and active smoking were independent predictors of nonresponse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Probiotics for induction of remission in ulcerative colitis.

Author: MallonP, McKayD, KirkS, GardinerK

Improved ulcerative colitis treatment
Ulcerative colitis

Ulcerative colitis (UC) is an inflammatory bowel disease affecting the colon, affecting about 10-20 people per 100,000 each year. While treatments exist, not everyone responds well, and some require surgery to remove the colon. Current treatments can also have significant side effects. Therefore, new treatments for UC are being sought. Probiotics, which are live microbes that can improve gut health, may be beneficial for UC by improving the balance of gut bacteria, strengthening the gut lining, and boosting the immune response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial.

Author: StremmelWolfgang, EhehaltRobert, AutschbachFrank, KarnerMax

Steroid withdrawal
Bloating

This study found that phosphatidylcholine reduced corticosteroid dependence more than placebo in patients with chronic steroid-refractory ulcerative colitis. 50% of patients receiving phosphatidylcholine achieved complete steroid withdrawal compared to 10% of placebo recipients. 80% of phosphatidylcholine recipients were able to discontinue steroid therapy without disease exacerbation compared to 10% of placebo recipients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Delayed-release oral mesalamine 4.8 g/day (800 mg tablets) compared to 2.4 g/day (400 mg tablets) for the treatment of mildly to moderately active ulcerative colitis: The ASCEND I trial.

Author: HanauerS B, SandbornW J, DallaireC, ArchambaultA, YacyshynB, YehC, Smith-HallN

Ulcerative colitis treatment

The study investigated whether an initial dose of 4.8 g/day delayed-release oral mesalamine is more effective than 2.4 g/day in patients with mildly to moderately active ulcerative colitis (UC).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Tacrolimus (FK506) for induction of remission in refractory ulcerative colitis.

Author: BaumgartDaniel C, MacdonaldJohn K, FeaganBrian

Short-term clinical improvement
Adverse events
Finger tremor
Gastroenteritis
Headache
Hot flush
Queasiness
Sepsis
Sleepiness
Stomach discomfort

Tacrolimus may be effective for short-term clinical improvement in patients with refractory ulcerative colitis, but more data are needed to determine its long-term efficacy and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Granulocytapheresis versus methylprednisolone in patients with acute ulcerative colitis: 12-month follow up.

Author: BresciGiampaolo, ParisiGiuseppe, MazzoniAlessandro, ScatenaFabrizio, CapriaAlfonso

Fewer side effects
Superior treatment

Granulocytapheresis (GCAP) was superior to methylprednisolone (MP) for the treatment of ulcerative colitis, with a remission rate of 72.5% versus 50%. GCAP also had fewer side effects than MP.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

A randomized controlled trial on the efficacy of synbiotic versus probiotic or prebiotic treatment to improve the quality of life in patients with ulcerative colitis.

Author: FujimoriShunji, GudisKatya, MitsuiKeigo, SeoTsuguhiko, YonezawaMasaoki, TanakaShu, TatsuguchiAtsushi, SakamotoChoitsu

Improved QOL

Patients with ulcerative colitis (UC) on synbiotic therapy experienced greater quality-of-life changes than patients on probiotic or prebiotic treatment. C-reactive protein decreased significantly only with synbiotic therapy (from 0.59 to 0.14 mg/dL, P = 0.04).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab.

Author: SandbornWilliam J, RutgeertsPaul, FeaganBrian G, ReinischWalter, OlsonAllan, JohannsJewel, LuJiandong, HorganKevin, RachmilewitzDaniel, HanauerStephen B, LichtensteinGary R, de VilliersWillem J S, PresentDaniel, SandsBruce E, ColombelJean Frédéric

Reduced colectomy
Reduced hospitalizations
Reduced surgeries
Malignancy
Serious infections
Tuberculosis

This study found that infliximab treatment was associated with a lower risk of colectomy in patients with moderately to severely active ulcerative colitis. The cumulative incidence of colectomy was 10% for infliximab and 17% for placebo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Sustained remission after steroids and leukocytapheresis induced response in steroid-dependent ulcerative colitis: results at 1 year.

Author: CabriadaJose L, IbargoyenNora, HernándezAnaiansi, BernalAntonio, CastiellaAgustín

Sustained Remission

Leukocytapheresis (LAP) plus steroids achieved clinical remission in 55% of patients with steroid-dependent ulcerative colitis (UC). At 1 year, 50% of these patients remained in steroid-free remission, particularly those who achieved initial endoscopic remission.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Meta-analysis: pre-operative infliximab treatment and short-term post-operative complications in patients with ulcerative colitis.

Author: YangZ, WuQ, WuK, FanD

Ulcerative colitis treatment
Postoperative complications

Pre-operative infliximab use increased the risk of short-term post-operative complications in patients with ulcerative colitis. Subgroup analysis suggests a trend towards increased post-operative infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

41.

Direct comparison of two different mesalamine formulations for the maintenance of remission in patients with ulcerative colitis: a double-blind, randomized study.

Author: ItoHiroaki, IidaMitsuo, MatsumotoTakayuki, SuzukiYasuo, AidaYoshiyuki, YoshidaToyomitsu, TakanoYuichi, HibiToshifumi

Maintained UC remission

A pH-dependent release formulation of mesalamine was noninferior to a time-dependent release formulation for maintaining remission in patients with ulcerative colitis. Remission tended to be longer in the group receiving the pH-dependent formulation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

Direct comparison of two different mesalamine formulations for the induction of remission in patients with ulcerative colitis: a double-blind, randomized study.

Author: ItoHiroaki, IidaMitsuo, MatsumotoTakayuki, SuzukiYasuo, SasakiHidetaka, YoshidaToyomitsu, TakanoYuichi, HibiToshifumi

Improved UC remission

A higher dose of the pH-dependent release formulation of mesalamine was more effective for inducing remission in patients with mild-to-moderate active ulcerative colitis. The pH-dependent release formulation was also preferable for patients with proctitis-type UC.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Clinical trial: probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN).

Author: MatthesHarald, KrummenerlThomas, GienschManfred, WolffCorinna, SchulzeJürgen

E. coli Nissle effective

The study found that rectal E. coli Nissle (EcN) enema application was effective in treating moderate distal ulcerative colitis (UC), with a dose-dependent efficacy. EcN was well tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Clinical trial: controlled, open, randomized multicentre study comparing the effects of treatment on quality of life, safety and efficacy of budesonide or mesalazine enemas in active left-sided ulcerative colitis.

Author: HartmannF, SteinJ,

Higher remission rate
Improved endoscopic and histological remission rates

Mesalazine enema was found to be significantly more effective than budesonide enema in achieving remission for active left-sided ulcerative colitis. At week 4, clinical remission rates were 77.2% for mesalazine and 63.5% for budesonide (P < 0.05). This difference was maintained at week 8 (77.4% vs. 64.4%, P < 0.05). Mesalazine also showed favorable trends in endoscopic and histological remission rates and IBDQ scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Acute severe ulcerative colitis in children: a systematic review.

Author: TurnerDan, GriffithsAnne M

Pediatric UC treatment

This study examines the treatment of ulcerative colitis (UC) in children, highlighting that it is often more severe than in adults, with more widespread disease and frequent severe flare-ups. The study summarizes key findings on treatment approaches, including: - Steroids are commonly used, with a 34% failure rate, and are generally recommended at doses of 1-1.5 mg/kg per day. - Restricting food is not typically helpful and is discouraged unless there are surgical concerns. - The Pediatric UC Activity Index (PUCAI) can help predict which children are likely to need additional medications. - Cyclosporine can be effective for short-term treatment, with an 81% success rate, but should be used for a limited time while transitioning to another medication. - Infliximab is also effective, with a 75% short-term and 64% one-year success rate. - Surgery (colectomy) may be necessary in severe cases, with considerations for long-term medication side effects, quality of life, and fertility for female patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Clinical trial: Effects of an oral preparation of mesalazine at 4 g/day on moderately active ulcerative colitis. A phase III parallel-dosing study.

Author: HiwatashiNobuo, SuzukiYasuo, MitsuyamaKeiichi, MunakataAkihiro, HibiToshifumi

Improved UC-DAI score

A higher dose of mesalazine (4 g/day) was significantly more effective in treating moderately active ulcerative colitis (UC) compared to a lower dose (2.25 g/day), with similar safety profiles.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis.

Author: FordAlexander C, SandbornWilliam J, KhanKhurram J, HanauerStephen B, TalleyNicholas J, MoayyediPaul

Induced remission
Prevented relapse

Biological therapies, including anti-tumor necrosis factor-α (TNFα) antibodies and natalizumab, were superior to placebo in inducing remission of active Crohn’s disease (CD) and ulcerative colitis (UC). Anti-TNFα antibodies were also superior to placebo in preventing relapse of quiescent CD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

[Topical therapy of ulcerative colitis].

Author: RoglerG, BeglingerC, MottetC, SeiboldF, GrossV

Treatment of ulcerative colitis

New topical medications for ulcerative colitis affecting the left side of the colon offer a better treatment option for many patients. Applying steroids and 5-aminosalicylic acid (5-ASA) rectally is associated with fewer side effects and is more effective than oral medications for mild to moderate left-sided colitis. While some believe that patients don't follow rectal treatments well, proper education about the benefits can improve compliance. Rectal medications are also effective for maintaining remission in distal colitis. New treatment guidelines now recommend topical therapies more often, and these papers specifically address the benefits of topical treatment for distal colitis, highlighting its advantages in everyday practice.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

49.

Probiotics for maintenance of remission in ulcerative colitis.

Author: NaidooKhimara, GordonMorris, FagbemiAndrew O, ThomasAdrian G, AkobengAnthony K

Treatment of ulcerative colitis

Ulcerative colitis is a chronic condition causing inflammation in the colon. Current treatments have side effects, so a new approach with fewer side effects is needed. Research suggests that modifying the bacteria in the gut (intestinal flora) with probiotics might reduce inflammation and prevent relapses in ulcerative colitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

The role of anti(myco)bacterial interventions in the management of IBD: is there evidence at all?

Author: Pineton de ChambrunGuillaume P, TorresJoana, Darfeuille-MichaudArlette, ColombelJean-Frédéric

Improved IBD treatment

This review examines the evidence for using antibiotics in treating inflammatory bowel disease (IBD), considering the potential role of bacteria in the disease's etiology.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

[Current status of elective surgical treatment of ulcerative colitis. A systematic review].

Author: Millán ScheidingMonica, Rodriguez MorantaFrancisco, Kreisler MorenoEsther, GoldaThomas, FraccalvieriDomenico, BiondoSebastiano

Treatment of UC
Infertility
Permanent stoma

While medications can help manage ulcerative colitis (UC), about 25-40% of people with this condition will eventually need surgery. The most common surgical procedure is restorative proctocolectomy with ileal pouch-anal anastomosis, which involves removing the colon and rectum and creating a pouch from the small intestine. While this surgery aims to improve quality of life, it is a complex procedure with potential risks, including infertility, permanent colostomy (a bag for waste), and the need for further surgery due to pouch-related complications. Doctors and patients should carefully consider all options and potential risks before making a decision about surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

52.

Randomised clinical trial: once- vs. twice-daily prolonged-release mesalazine for active ulcerative colitis.

Author: FlouriéB, HagègeH, TucatG, MaetzD, HébuterneX, KuyvenhovenJ P, TanT G, PierikM J, MascleeA A M, DewitO, ProbertC S, AouchetaD,

Improved ulcerative colitis symptoms

Once-daily prolonged-release mesalazine (4 g) was as effective and well tolerated as twice-daily mesalazine (2 g) for inducing remission in patients with mild-to-moderately active ulcerative colitis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

Decision tree construction and cost-effectiveness analysis of treatment of ulcerative colitis with pentasa® mesalazine 2 g sachet.

Author: NishikawaAlvaro Mitsunori, PaladiniLuciano, DelfiniRégis, KotzePaulo Gustavo, ClarkOtavio

Improved outcomes
Mesalazine granules
Low compliance
Ulcerative rectocolitis

Unspecified Ulcerative Rectocolitis is a chronic condition that affects millions worldwide. While aminosalicylates are recommended for induction and maintenance of remission, poor adherence to treatment due to multiple daily doses is a challenge. This research explores the effectiveness of once-daily mesalazine granules for improving adherence and patient outcomes.

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

54.

Biological agents for moderately to severely active ulcerative colitis: a systematic review and network meta-analysis.

Author: DaneseSilvio, FiorinoGionata, Peyrin-BirouletLaurent, LucenteforteErsilia, VirgiliGianni, MojaLorenzo, BonovasStefanos

Effective treatment for UC

Biological agents are effective for ulcerative colitis (UC), but more research is needed to determine the best therapeutic option. In a meta-analysis of 7 double-blind, placebo-controlled trials, all biological agents (adalimumab, golimumab, infliximab, and vedolizumab) showed greater clinical responses, remissions, and mucosal healings than placebo for induction therapy. Infliximab was more effective than adalimumab for inducing clinical response and mucosal healing.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis: a double-blind randomized placebo controlled clinical trial.

Author: PetersenAndreas Munk, MirsepasiHengameh, HalkjærSofie Ingdam, MortensenEsben Munk, Nordgaard-LassenInge, KrogfeltKaren Angeliki

EcN treatment
Ulcerative colitis

This study investigates the effectiveness of Escherichia coli Nissle 1917 (EcN) as an add-on therapy for patients with active ulcerative colitis (UC). EcN is a probiotic bacterium that has been used to manage UC, and this study examines the potential benefits of EcN in combination with conventional therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

Drug therapies for ulcerative proctitis: systematic review and meta-analysis.

Author: LieMitchell R K L, KanisShannon L, HansenBettina E, van der WoudeC Janneke

5-ASA
Anti-TNF-α agents
Corticosteroids
Thiopurines
Ulcerative proctitis

Ulcerative proctitis (UP), a form of ulcerative colitis affecting only the rectum, is typically treated using the same stepwise approach as more extensive colitis. However, research on the effectiveness of these treatments for UP specifically is limited. This review aims to analyze research on drug treatments for inducing and maintaining remission in patients with UP.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Methotrexate for induction of remission in ulcerative colitis.

Author: ChandeNilesh, WangYongjun, MacDonaldJohn K, McDonaldJohn W D

Methotrexate
Ulcerative colitis

This study examines the use of methotrexate, a medication that suppresses the immune system, for treating ulcerative colitis (UC) in patients who do not respond to or become dependent on steroids, which are common initial treatments for UC. The study provides an updated review of research on the effectiveness of methotrexate for UC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Combined diosmectite and mesalazine treatment for mild-to-moderate ulcerative colitis: a randomized, placebo-controlled study.

Author: JiangXue-Liang, WangHua-Hong, CuiHui-Fei

Diosmectite + mesalazine UC
UC relapse rate

This study found that combined diosmectite and mesalazine treatment successfully induced and maintained the treatment of active mild-to-moderate ulcerative colitis (UC). The Diosmectite group had a significantly higher clinical remission rate and mucosal healing rate compared to the Placebo group at both 8 weeks and 52 weeks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

59.

Systematic review with meta-analysis: the efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failed.

Author: GisbertJ P, MarínA C, McNichollA G, ChaparroM

Improved CD symptoms
Adverse events
Discontinuation

The efficacy of a second anti-TNF in CD patients largely depends on the cause for switching. The remission rate is higher when the reason to withdraw the first anti-TNF is intolerance (61%), compared with secondary (45%) or primary failure (30%).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

TELEmedicine for Patients with Inflammatory Bowel Disease (TELE-IBD): Design and implementation of randomized clinical trial.

Author: CrossRaymond K, JambaulikarGuruprasad, LangenbergPatricia, TracyJ Kathleen, CollinsJoseph F, KatzJonathan, RegueiroMiguel, SchwartzDavid A, QuinnCharlene C

IBD treatment

Inflammatory bowel diseases (IBD), like ulcerative colitis and Crohn's disease, are chronic conditions with alternating periods of worsening symptoms and symptom-free periods. These symptoms severely impact quality of life and lead to increased healthcare use. Although effective treatments exist, outcomes are often poor due to factors like non-adherence to treatment, medication intolerance, inconsistent monitoring, insufficient patient understanding, and limited access to care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

61.

Anti-TNF-A therapy about infliximab and adalimamab for the effectiveness in ulcerative colitis compared with conventional therapy: a meta-analysis.

Author: ZhouZheng, DaiCong, LiuWei-Xin

Improved clinical remission
Improved clinical response
Colectomy rate

Infliximab was significantly more effective in inducing clinical response in ulcerative colitis (UC) compared to conventional therapy. Adalimumab was significantly more effective in inducing both clinical remission and clinical response compared to conventional therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

62.

Characterizing unmet medical need and the potential role of new biologic treatment options in patients with ulcerative colitis and Crohn's disease: a systematic review and clinician surveys.

Author: GordonJason P, McEwanPhil C, MaguireAndy, SugrueDaniel M, PuellesJorge

Treatment failure

High treatment failure rates with existing biologics for ulcerative colitis (UC) and Crohn's disease (CD) indicate a need for new treatment options. These new treatments should be investigated in head-to-head randomized trials to compare their effectiveness and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Infliximab is superior to other biological agents for treatment of active ulcerative colitis: A meta-analysis.

Author: MeiWei-Qun, HuHui-Zhen, LiuYing, LiZhi-Chen, WangWei-Guo

Effective for UC
None mentioned

Biological agents are superior to placebo for ulcerative colitis (UC) treatment in both induction and maintenance phases, with a similar safety profile. Infliximab was more effective than other biological agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

64.

Systematic Review: Rectal Therapies for the Treatment of Distal Forms of Ulcerative Colitis.

Author: CohenRussell D, DalalSushila R

UC treatment

Many treatments are available for ulcerative colitis (UC) that primarily affects the lower part of the colon. Rectal medications are often recommended, either alone or with oral medications, but they are underused despite having good effectiveness and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Quality of Life After Total Proctocolectomy With Ileostomy or IPAA: A Systematic Review.

Author: MurphyPatrick B, KhotZaid, VogtKelly N, OttMichael, DuboisLuc

Disease control
IPAA
Ileostomy

Both total proctocolectomy with ileostomy and IPAA appear equivalent in terms of overall health-related quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Long-Term Benefit of Mesalamine Granules for Patients Who Achieved Corticosteroid-Induced Ulcerative Colitis Remission.

Author: LichtensteinGary R, GordonGlenn L, ZakkoSalam, MurthyUma, SedghiShahriar, PruittRon, BarrettAndrew C, BorteyEnoch, PatersonCraig, ForbesWilliam P

MG for UC

This study investigates the effectiveness of mesalamine granules (MG) for maintaining remission in patients with ulcerative colitis (UC) who have achieved remission with corticosteroids. The study explores the potential benefits of MG in reducing steroid exposure and preventing relapse in UC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis.

Author: CarbonnelFranck, ColombelJean Frédéric, FilippiJérome, KatsanosKonstantinos H, Peyrin-BirouletLaurent, AllezMathieu, NachuryMaria, NovacekGottfried, DaneseSilvio, AbitbolVered, BossaFabrizio, MoreauJacques, BommelaerGilles, BourreilleArnaud, FumeryMathurin, RoblinXavier, ReinischWalter, BouhnikYoram, BrixiHedia, SeksikPhilippe, MalamutGeorgia, FärkkiläMartti, CoulibalyBaya, DewitOlivier, LouisEdouard, DeplanqueDominique, MichettiPierre, SarterHélène, LaharieDavid,

Improved clinical remission
Adverse events
Ineffective for steroid-free remission

This randomized controlled trial evaluated the safety and efficacy of parenteral methotrexate for treating steroid-dependent ulcerative colitis (UC). While methotrexate did not demonstrate superiority to placebo in inducing steroid-free remission, it did induce clinical remission without steroids in a significantly larger proportion of patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis.

Author: ShiYanqiang, DongYiwei, HuangWenhui, ZhuDecong, MaoHua, SuPeizhu

FMT effective
FMT safe

Fecal microbiota transplantation (FMT) provides a promising effect for ulcerative colitis (UC) with few adverse events. It may be associated with an increase in microbiota diversity and richness, similarity, and certain change of bacterial composition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Efficacy and Safety of Beclomethasone Dipropionate versus 5-Aminosalicylic Acid in the Treatment of Ulcerative Colitis: A Systematic Review and Meta-Analysis.

Author: ZhaoXin, LiNan, RenYiMing, MaTao, WangChunLi, WangJun, YouShengYi

UC treatment

Ulcerative colitis (UC) is a chronic condition causing inflammation in the colon. Mesalazine (5-ASA) and beclomethasone dipropionate (BDP) are commonly used medications for UC. This study compared the effectiveness of these two treatments for UC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Systematic review: second-generation vs. conventional corticosteroids for induction of remission in ulcerative colitis.

Author: D'HaensG

Safe alternative
Poor tolerability

While oral corticosteroids are effective for treating ulcerative colitis (UC), their side effects limit their use. This study explores the potential of second-generation, gut-selective corticosteroids as a safer alternative for UC treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Systematic Review with Network Meta-Analysis: Comparative Efficacy of Biologics in the Treatment of Moderately to Severely Active Ulcerative Colitis.

Author: VickersAdrian D, AinsworthClaire, ModyReema, BergmanAnnika, LingCaroline S, MedjedovicJasmina, SmythMichael

Effective UC induction treatment
Improved maintenance UC treatment
Improved mucosal healing

A network meta-analysis comparing biologics for ulcerative colitis (UC) found all treatments effective for induction. Vedolizumab showed possible benefits for maintenance versus all comparators, both in anti-TNF naïve and experienced patients, suggesting potential advantages regardless of prior treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

EFFICACY OF TACROLIMUS FOR INDUCTION OF REMISSION IN PATIENTS WITH MODERATE-TO-SEVERE ULCERATIVE COLITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Author: LasaJuan, OliveraPablo

Remission induction

This study reviewed 22 studies on the use of tacrolimus, a calcineurin inhibitor, for inducing remission in patients with moderate-to-severe ulcerative colitis. The study found that tacrolimus was more effective than placebo at inducing remission, with a lower risk of treatment failure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

73.

Efficacy of Curcumin as Adjuvant Therapy to Induce or Maintain Remission in Ulcerative Colitis Patients: an Evidence-based Clinical Review.

Author: SimadibrataMarcellus, HalimkesumaChristopher Christian, SuwitaBenedicta Mutiara

Improved UC treatment

This study examined the potential benefits of curcumin as an adjuvant therapy for ulcerative colitis (UC), considering its anti-inflammatory and antioxidant properties and the need for alternative treatment options with fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.

Author: IqbalUmair, AnwarHafsa, QuadriAbdulhadi Affan

Improved UC treatment

This systematic review and meta-analysis investigated the role of curcumin as an adjuvant therapy for ulcerative colitis (UC), considering its potential to improve clinical and endoscopic remission.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Etrolizumab versus infliximab in the treatment of induction phase of ulcerative colitis: A systematic review and indirect comparison.

Author: MotaghiEhsan, Ghasemi-PirbalutiMasoumeh, ZabihiMohsen

Fewer adverse events
No significant difference in remission
Need for further trials

This meta-analysis compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis. Seven trials showed no significant differences in clinical remission and serious adverse events between etrolizumab and infliximab. Etrolizumab had significantly fewer adverse events than infliximab. Further trials are needed to compare other parameters of efficacy, such as clinical response and mucosal healing.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

Systematic review with meta-analysis: high prevalence and cost of continued aminosalicylate use in patients with ulcerative colitis escalated to immunosuppressive and biological therapies.

Author: MaChristopher, GuizzettiLeonardo, CiprianoLauren E, ParkerClaire E, NguyenTran M, GregorJames C, ChandeNilesh, FeaganBrian G, JairathVipul

Approximately 80% of patients with ulcerative colitis entering clinical trials continue to use aminosalicylates. Further research is needed to determine the benefits and harms of continuing vs stopping aminosalicylates during escalating therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

A randomised, double-blind, placebo-controlled trial of a multi-strain probiotic in patients with asymptomatic ulcerative colitis and Crohn's disease.

Author: BjarnasonIngvar, SissionGuy, HayeeBu'Hussaine

Improved IBD treatment

The role of gut microflora in inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD), is being investigated. Probiotics may offer a potential adjuvant treatment, but their efficacy requires further research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

78.

Probiotics’ effectiveness on symptoms, histological features and feeding tolerance in ulcerative colitis

Author: Sánchez-MoralesAdhara, Pérez-AyalaMayte Fabiola, Cruz-MartínezMargarita, Arenas-OsunaJesús, Ramírez-MendozaPablo, CenicerosRodrigo Alberto, Mora-CañasEva Marina, Cruz-DomínguezPilar, Saavedra-SalinasMiguel Ángel

Improved UC activity
Improved food tolerance
Improved histological findings

A combination of six strains of probiotics showed a beneficial short-term effect on symptoms, histological findings and feeding tolerance in patients with UC. There was an improvement in disease activity (52.9% vs. 23.5%) and histological index (82.3% vs. 41.1%).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

79.

Outcomes and Strategies to Support a Treat-to-target Approach in Inflammatory Bowel Disease: A Systematic Review.

Author: ColombelJean-Frédéric, D'haensGeert, LeeWan-Ju, PeterssonJoel, PanaccioneRemo

Crohn's disease and ulcerative colitis treatment
Treat-to-target management

Crohn's disease and ulcerative colitis are typically treated based on symptoms, but a new approach focuses on addressing underlying inflammation. This "treat-to-target" approach aims to manage inflammation early in the disease, prevent it from worsening, and improve long-term outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Efficacy and safety of bifid triple viable plus aminosalicylic acid for the treatment of ulcerative colitis: A systematic review and meta-analysis.

Author: ChenMu-Yuan, QiuZhen-Wen, TangHong-Mei, ZhuangKun-Hai, CaiQing-Qun, ChenXin-Lin, LiHui-Biao

Improved UC treatment

This study investigated the efficacy and safety of bifid triple viable (BTV) plus aminosalicylic acid (ASA) in treating ulcerative colitis (UC), considering the potential benefits of probiotics in reducing drug-induced adverse reactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Histological Remission in Ulcerative Colitis: Under the Microscope Is the Cure.

Author: ChateauThomas, FeakinsRoger, Marchal-BressenotAude, MagroFernando, DaneseSilvio, Peyrin-BirouletLaurent

Improved UC treatment

This study reviews the concept of histological remission (HR) as a treatment goal for ulcerative colitis (UC), highlighting its association with better outcomes and the need for further research on HR definitions and its potential for disease modification.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

Efficacy and safety of biologic agents and tofacitinib in moderate-to-severe ulcerative colitis: A systematic overview of meta-analyses.

Author: PantavouKaterina, YiallourouAnneza I, PiovaniDaniele, EvripidouDespo, DaneseSilvio, Peyrin-BirouletLaurent, BonovasStefanos, NikolopoulosGeorgios K

Efficacious treatment
Safe treatment
Adverse events

Biologics and tofacitinib are efficacious and safe for treating ulcerative colitis (UC). All four biologics (adalimumab, golimumab, infliximab, vedolizumab) and tofacitinib were superior to placebo in terms of efficacy. Infliximab may be better than adalimumab and golimumab for inducing clinical response and mucosal healing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Probiotics for maintenance of remission in ulcerative colitis.

Author: Iheozor-EjioforZipporah, KaurLakhbir, GordonMorris, BainesPatricia Anne, SinopoulouVasiliki, AkobengAnthony K

Ulcerative colitis treatment

Ulcerative colitis is a condition that causes inflammation in the colon. While many people respond to treatment, some don't, and current therapies can have side effects. Probiotics, which are live bacteria that are good for your gut health, are being studied as a potential new treatment. They may help by improving the balance of bacteria in the gut, strengthening the gut barrier, and boosting the immune system.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Probiotics for induction of remission in ulcerative colitis.

Author: KaurLakhbir, GordonMorris, BainesPatricia Anne, Iheozor-EjioforZipporah, SinopoulouVasiliki, AkobengAnthony K

Ulcerative colitis treatment

Ulcerative colitis is a bowel disease affecting about 10-20 out of every 100,000 people. While many people find relief with treatments, a significant number don't respond to standard medications, and some experience side effects. Probiotics, which are live bacteria beneficial for gut health, are being investigated as a potential alternative treatment. They may help by restoring the balance of gut bacteria, strengthening the intestinal lining, and boosting the immune response in the gut.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Assessing the efficacy and safety of fecal microbiota transplantation and probiotic VSL#3 for active ulcerative colitis: A systematic review and meta-analysis.

Author: DangXiaofei, XuMingjie, LiuDuanrui, ZhouDajie, YangWeihua

Ulcerative colitis treatment

Fecal microbiota transplantation (FMT), which involves transferring healthy gut bacteria from a donor to a recipient, is a promising treatment for many gut problems, including C. difficile infection and inflammatory bowel diseases like ulcerative colitis. Changes in the gut bacteria may be a key factor in causing ulcerative colitis, and restoring a healthy balance of bacteria through FMT or taking probiotics might help improve symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Endoscopic Submucosal Dissection for Visible Dysplasia Treatment in Ulcerative Colitis Patients: Cases Series and Systematic Review of Literature.

Author: MantaRaffaele, ZulloAngelo, TelescaDonato Alessandro, CastellaniDanilo, GermaniUgo, Reggiani BonettiLuca, ConigliaroRita, GalloroGiuseppe

ESD
UC patients
colonic lesions
bleeding
perforation

This study evaluated the efficacy of endoscopic submucosal dissection (ESD) for removing non-invasive neoplastic lesions in the colon of patients with ulcerative colitis (UC). The study found high rates of en bloc and R0 resection, with low complication rates. A pooled analysis of data from other studies confirmed the safety and efficacy of ESD in UC patients. This suggests that ESD is a suitable technique for removing neoplastic lesions in the colon of selected UC patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Relationship Between Combined Histologic and Endoscopic Endpoints and Efficacy of Ustekinumab Treatment in Patients With Ulcerative Colitis.

Author: LiKatherine, MaranoColleen, ZhangHongyan, YangFeifei, SandbornWilliam J, SandsBruce E, FeaganBrian G, RubinDavid T, Peyrin-BirouletLaurent, FriedmanJoshua R, De HertoghGert

Reduced ulcerative colitis activity

Histologic improvement in patients with ulcerative colitis (UC) treated with ustekinumab was associated with clinical remission and lower disease activity scores. The combination of histologic and endoscopic improvement, referred to as histo-endoscopic mucosal healing, was associated with higher rates of clinical remission and corticosteroid-free remission.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

88.

Acupuncture for ulcerative colitis: a systematic review and meta-analysis of randomized clinical trials.

Author: WangXiao, ZhaoNan-Qi, SunYu-Xin, BaiXue, SiJiang-Tao, LiuJian-Ping, LiuZhao-Lan

Ulcerative colitis treatment

Ulcerative colitis is a chronic condition causing diarrhea, bloody stools, and abdominal pain. It's becoming more common. Acupuncture is being used more and more to treat ulcerative colitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis.

Author: LasaJuan S, OliveraPablo A, DaneseSilvio, Peyrin-BirouletLaurent

Clinical remission
Reduced progression
Reduced recurrence
Adverse events

This network meta-analysis compared the efficacy and safety of biologics and small molecule drugs for treating moderate-to-severe ulcerative colitis. Upadacitinib was found to be superior for inducing clinical remission but had more adverse events compared to other treatments. Vedolizumab had the best safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

The Clinical Significance of Eosinophils in Ulcerative Colitis: A Systematic Review.

Author: MookhoekAart, HaasnootMaria L, BredenoordAlbert J, MaChristopher, JairathVipul, PaiRish K

Eosinophils in UC

This study explored the association between eosinophils and clinical outcomes in ulcerative colitis (UC), considering their potential role in disease pathogenesis and treatment response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

Early Symptomatic Improvement After Ustekinumab Therapy in Patients With Ulcerative Colitis: 16-Week Data From the UNIFI Trial.

Author: DaneseSilvio, SandsBruce E, AbreuMaria T, O'BrienChristopher D, BravatàIvana, NazarMaciej, MiaoYe, WangYanli, RowbothamDavid, LeongRupert W L, ArasaradnamRamesh P, AfifWaqqas, MaranoColleen

Rapid symptom relief

This study found that ustekinumab improved symptoms in patients with ulcerative colitis (UC) compared with placebo in as early as 7 days, indicating a rapid onset of effect after induction.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

92.

Probiotics in the Treatment of Inflammatory Bowel Disease in Adulthood: A Systematic Review.

Author: LorentzAxel, MüllerLeonie

Probiotic treatment for IBD

This review examined the potential benefits of probiotics for patients with Crohn's disease (CD) and ulcerative colitis (UC), considering the challenges of current IBD treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

93.

Tacrolimus (FK506) for induction of remission in corticosteroid-refractory ulcerative colitis.

Author: GordonMorris, SinopoulouVassiliki, AkobengAnthony K, PanaMirela, GasieaRehab, MoranGordon William

Ulcerative colitis remission
Adverse events

Tacrolimus may be superior to placebo for achieving clinical remission and clinical improvement in corticosteroid-refractory ulcerative colitis. Further research is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Perioperative Management of Ulcerative Colitis: A Systematic Review.

Author: LeeKate E, FayeAdam S, VermeireSéverine, ShenBo

Ulcerative colitis management

People with ulcerative colitis may need surgery to remove their colon if medication doesn't work. Managing this condition is complicated because there are many factors to consider, including how well the patient's overall health is and the best use of medications before and after surgery, as there's no clear consensus on which medications are best and how to use them.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

95.

Prevalence of aphthous stomatitis in patients with inflammatory bowel disease after the treatment with monoclonal antibodies: a systematic review and meta-analysis.

Author: Salgado-PeralvoA-O, Montero-AlonsoM, KewalramaniN, Pérez-SayánsM, Mateos-MorenoM-V, Garcillán-IzquierdoM-R

IBD treatment

This study aims to determine which type of medication, anti-TNFs or vedolizumab (VDZ), is better at reducing mouth sores (aphthous stomatitis or AS) in people with inflammatory bowel disease (IBD). AS is a common complication of IBD, and the study seeks to compare the effectiveness of these medications in managing this symptom.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

96.

Impact of Synbiotic Therapy on the Quality of Life in Patients with Mild-to-Moderately Active Ulcerative Colitis.

Author: Kamarli AltunHulya, Akal YildizEmine, AkinMete

Ulcerative colitis treatment

This study investigated the impact of synbiotic treatment on the quality of life of individuals with mild to moderate ulcerative colitis. Synbiotics, a combination of probiotics and prebiotics, are known to improve gut health. This study aims to determine if synbiotics can alleviate symptoms, improve quality of life, and potentially reduce the need for other treatments in patients with ulcerative colitis.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

97.

Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trial.

Author: FeaganBrian G, SandsBruce E, SandbornWilliam J, GerminaroMatthew, VetterMarion, ShaoJie, ShengShihong, JohannsJewel, PanésJulián,

Ulcerative colitis treatment

This study examines whether combining guselkumab and golimumab is more effective for treating ulcerative colitis than either medication alone. Ulcerative colitis is a chronic inflammatory bowel disease with limited treatment options.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

98.

Mercaptopurine for the Treatment of Ulcerative Colitis: A Randomized Placebo-Controlled Trial.

Author: LöwenbergMark, VolkersAdriaan, van GennepSara, MookhoekAart, MontazeriNahid, ClasquinEsmé, DuijvesteinMarjolijn, van BodegravenAdriaan, RietdijkSvend, JansenJeroen, van AsseldonkDirk, van der ZandenEsmerij, DijkgraafMarcel, WestRachel, de BoerNanne, D'HaensGeert

Endoscopic improvement
Histological improvement
UC remission
Adverse events

Therapeutic drug monitoring (TDM)-guided mercaptopurine treatment was superior to placebo in achieving clinical, endoscopic, and histological remission in patients with ulcerative colitis (UC). Mercaptopurine resulted in a significantly higher remission rate, but also a greater number of adverse events. TDM-based dose adjustments led to lower mercaptopurine doses at week 52.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

99.

Effects of Traditional Chinese Medicine on Serum Cytokines for the Dampness-heat Syndrome of Ulcerative Colitis: A Systematic Review and Meta-analysis.

Author: XuYuan, LiuYu, LuJian, WuJiong

UC treatment

Ulcerative colitis (UC) is a long-term condition affecting the large intestine. Inflammation in the gut is driven by chemicals called cytokines. Traditional Chinese medicine (TCM) has a long history of treating UC. This study likely investigates how TCM approaches might address inflammation in UC.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

100.

Systematic review with meta-analysis: Medical therapies for treatment of ulcerative proctitis.

Author: AruljothyAchuthan, SinghSiddharth, NarulaNeeraj, MoranGordon W, VuyyuruSudheer K, HoganMalcolm, ZayadiAlexa, MacDonaldJohn K, CaronBenedicte, DaneseSilvio, Peyrin BirouletLaurent, MaChristopher, JairathVipul

UP remission

Topical 5-aminosalicylic acid (5-ASA) and corticosteroids are effective for active ulcerative proctitis (UP). Topical 5-ASA may be effective for maintenance of remission. Tacrolimus may be effective for induction of remission. Etrasimod may be effective for induction and for maintenance of remission.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

101.

Comparative of the effectiveness and safety of biological agents, small molecule drugs, and microbiome therapies in ulcerative colitis: Systematic review and network meta-analysis.

Author: GaoJie, NieRui, ChenYalan, YangWei, RenQian

UC treatment

Biological agents are often used to treat moderate to severe ulcerative colitis (UC). However, new treatments like small-molecule drugs and therapies that target gut bacteria are emerging. This study will compare the effectiveness and safety of these different approaches for treating UC.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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