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Therapeutic mechanism in seasonal affective disorder: do fluoxetine and light operate through advancing circadian phase?

Author: EnnsMurray W, LamRaymond W, LevitanRobert D, LevittAnthony J, MichalakErin E, MorehouseRachel, MurrayGreg

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found no evidence to support the theory that circadian phase advance mediates the therapeutic mechanism of light therapy for winter Seasonal Affective Disorder (SAD), despite both light therapy and fluoxetine being associated with antidepressant effects and phase advance.
Paper Details　
Original Abstract of the Article :
In the context of Lewy's phase delay hypothesis, the present study tested whether effective treatment of winter Seasonal Affective Disorder (SAD) is mediated by advancing of circadian phase. Following a baseline week, 78 outpatients with SAD were randomized into 8 weeks of treatment with either fluo...See full text at original site
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引用元：
https://doi.org/10.1080/07420520500263292

データ提供：米国国立医学図書館（NLM）

Unraveling the Therapeutic Mechanism of Seasonal Affective Disorder Treatment

The field of [psychiatry] continues to seek a deeper understanding of the [therapeutic mechanisms] involved in treating [seasonal affective disorder], a mood disorder linked to [seasonal changes] and [circadian rhythm disruptions]. This study explores the potential role of [circadian phase advance] in the effectiveness of [fluoxetine] and [light therapy] in treating [seasonal affective disorder]. The study aims to determine whether [circadian phase advance] mediates the [antidepressant effects] of these treatments.

Circadian Phase Advance Not the Sole Mediator of Treatment Effectiveness

While the study found that both [fluoxetine] and [light therapy] were associated with significant [antidepressant effects] and [circadian phase advance], there was no direct correlation between the degree of [symptom change] and the degree of [phase change]. This suggests that [circadian phase advance] may not be the sole mediator of [therapeutic effects] in [seasonal affective disorder], highlighting the complex interplay of factors influencing treatment outcomes.

Expanding Our Understanding of Seasonal Affective Disorder

This research underscores the need for continued research to fully understand the [therapeutic mechanisms] of [seasonal affective disorder] treatment. Like the shifting dunes of a desert, the complex interplay of factors influencing [mood disorders] requires a multifaceted approach to understanding and treating these conditions. Future research should focus on identifying other potential mediators of [therapeutic effects] and developing personalized treatment strategies for [seasonal affective disorder].

Dr.Camel's Conclusion

While this study suggests that circadian phase advance may not be the sole mediator of treatment effectiveness in seasonal affective disorder, it highlights the complexity of this condition and the need for further research. It's like exploring a desert – each new discovery leads us to a deeper understanding of the vast and intricate landscape.

Date :
  1. Date Completed 2006-01-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16298778

DOI: Digital Object Identifier

10.1080/07420520500263292

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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