Paper Details

  1. Home
  2. Paper Details

Galactorrhea during treatment with trimipramine. A case report.

Author: GreilW, WolfspergerM

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
LetterA written message for communication and exchange of information between individuals.

Overview

This case report describes a 31-year-old female patient who developed galactorrhea while under treatment with trimipramine, a tricyclic antidepressant, in combination with paroxetine, a selective serotonin reuptake inhibitor (SSRI). The authors suggest that the combination of trimipramine with an SSRI may have aggravated the problem due to the prolactin-stimulating effects of SSRIs and the potential for elevated trimipramine plasma levels due to SSRI inhibition of cytochrome P450 2D6.
Paper Details　
Original Abstract of the Article :
Trimipramine, a tricyclic antidepressant, faced renewed attention in the last decade for its well-established antidepressant as well as its sleep-promoting properties. While the antidepressant mode of action of trimipramine is still unclear, its antihistaminic and anticholinergic potency is far bett...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1055/s-2005-916189

データ提供：米国国立医学図書館（NLM）

Galactorrhea: A Case of Unexpected Side Effects

The world of medicine, my dear friend, is like a vast desert, filled with surprises and unexpected encounters. One such encounter is galactorrhea, a condition characterized by abnormal milk production, even in individuals who are not pregnant or breastfeeding. This case report describes a patient who developed galactorrhea while taking trimipramine, a tricyclic antidepressant.

A Tricky Combination

The patient in this case report was initially treated with paroxetine, a selective serotonin reuptake inhibitor (SSRI). However, due to persistent insomnia, trimipramine was added to the regimen. This combination led to the development of galactorrhea.

Understanding the Underlying Mechanisms

The authors suggest that the combination of trimipramine and an SSRI may have led to an increase in prolactin levels, a hormone that stimulates milk production. This is due to the antidopaminergic effects of both drugs, which inhibit the release of dopamine, a hormone that normally suppresses prolactin secretion.

Dr. Camel's Conclusion

This case report reminds us that even seemingly common medications can have unexpected side effects. It's important to be aware of these potential complications and to work closely with healthcare professionals to ensure the safe and effective use of medications. Remember, as a wise camel knows, navigating the desert of healthcare requires constant vigilance and a keen eye for detail.

Date :
  1. Date Completed 2006-01-05
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

16342006

DOI: Digital Object Identifier

10.1055/s-2005-916189

Related Literature

Article Analysis
・Side Effects of trimipramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.