Enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: a randomized crossover trial.

Author: BardenA, ClaxtonA, EikelboomJ W, GilmoreG, HankeyG J, NormanP E, StatonJ, ThomJ, YiQ

Paper Details 
Original Abstract of the Article :
OBJECTIVE: We aimed to determine whether adding clopidogrel to aspirin in patients at high risk of future cardiovascular events would suppress laboratory measures of the antiplatelet effects of aspirin; and have greater platelet inhibitory effects in patients with the least inhibition of platelets b...See full text at original site
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引用元:
https://doi.org/10.1111/j.1538-7836.2005.01640.x

データ提供:米国国立医学図書館(NLM)

Clopidogrel: An Enhanced Antiplatelet Effect

This study delves into the fascinating world of platelet function, exploring the effectiveness of combining two antiplatelet drugs, clopidogrel and aspirin, for preventing cardiovascular events. It's like creating a specialized team in the desert to combat the dangers of sandstorms. The study aimed to determine whether clopidogrel, when added to aspirin, would enhance the antiplatelet effect, particularly in patients whose platelets were less responsive to aspirin alone. The researchers investigated the impact of this combination therapy on various laboratory measures of platelet activity, providing valuable insights into the potential benefits of combining these medications.

Clopidogrel: A Powerful Ally in the Fight Against Platelet Aggregation

This study suggests that clopidogrel can enhance the antiplatelet effect of aspirin, particularly in patients whose platelets are less responsive to aspirin alone. This finding highlights the potential benefits of combining these medications, potentially providing a more comprehensive approach to preventing cardiovascular events. The study also suggests that patients with lower platelet inhibition by aspirin alone may benefit most from the addition of clopidogrel, emphasizing the importance of personalized treatment approaches.

Navigating the Desert of Cardiovascular Health

This research provides valuable insights into the intricate world of platelet function and the potential benefits of combining clopidogrel with aspirin for managing cardiovascular risk. It is important to note that this study was conducted on a small group of patients, and further research is needed to confirm these findings in larger populations. However, the results suggest a potential benefit for patients who are less responsive to aspirin alone, highlighting the importance of individualized treatment approaches.

Dr.Camel's Conclusion

This study reveals the potential benefits of combining clopidogrel with aspirin, particularly in patients whose platelets are less responsive to aspirin alone, offering a potentially more effective approach to managing cardiovascular risk.
Date :
  1. Date Completed 2006-02-21
  2. Date Revised 2023-08-29
Further Info :

Pubmed ID

16359503

DOI: Digital Object Identifier

10.1111/j.1538-7836.2005.01640.x

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English

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