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Structural effects of raloxifene on the proximal femur: results from the multiple outcomes of raloxifene evaluation trial.

Author: BeckT J, CransG G, DaphtaryM M, DesaiahD, HarperK D, SemanickL M, Uusi-RasiK

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This review discusses the effects of raloxifene on bone mineral density (BMD) and fracture risk. Raloxifene has been shown to improve spine BMD and reduce vertebral fractures, but further research is needed to confirm its effects on hip strength.
Paper Details　
Original Abstract of the Article :
Raloxifene improves spine bone mineral density (BMD), and its ability to reduce vertebral fractures by 40-50% suggests that it increases vertebral strength. Positive effects on hip BMD suggest a similar strengthening of the hip, but dimensional ambiguities in BMD by dual energy x-ray absorptiometry ...See full text at original site
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引用元：
https://doi.org/10.1007/s00198-005-0028-3

データ提供：米国国立医学図書館（NLM）

Raloxifene's Impact on Bone Strength: A Look Beyond Bone Mineral Density

Osteoporosis is a debilitating condition that weakens bones and increases the risk of fractures. This study investigated the effects of raloxifene, a medication used to prevent and treat osteoporosis, on the structure of the proximal femur. The researchers analyzed data from the Multiple Outcomes of Raloxifene Evaluation (MORE) trial, finding that raloxifene significantly improved spine bone mineral density (BMD) but did not show a comparable reduction in hip fractures.

Raloxifene and Bone Strength: A Complex Picture

This research highlights the importance of considering bone strength beyond BMD measurements. While raloxifene has been shown to improve BMD, its ability to prevent hip fractures may be limited. Further research is needed to fully understand the effects of raloxifene on bone strength and its implications for fracture prevention.

Building Strong Bones: A Desert Oasis of Strength

Osteoporosis can make our bones as fragile as desert sand. This research explores the potential of raloxifene to strengthen bones, reminding us that the journey to strong bones may involve more than just bone mineral density.

Dr.Camel's Conclusion

The desert of osteoporosis can be a treacherous place, leaving our bones vulnerable to fractures. This research reminds us that building strong bones requires a multifaceted approach, considering not just bone mineral density but also overall bone strength.

Date :
  1. Date Completed 2007-02-16
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

16392026

DOI: Digital Object Identifier

10.1007/s00198-005-0028-3

Related Literature

Article Analysis
・Effects of raloxifene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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