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In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes.

Author: AnzenbacherPavel, AnzenbacherováEva, BucharEvzen, HolýAntonín, KmoníckováEva, PotmesilPetr, ZídekZdenek

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Adefovir, an antiviral drug, partially degraded cytochrome P450 protein in rats.
Paper Details　
Original Abstract of the Article :
Interference of antiviral agent adefovir, i.e. 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with microsomal drug metabolizing system was investigated in rats. The content of total liver cytochrome P450 (CYP) was lowered while that of its denaturated form, P420, was elevated in animals intraperitoneal...See full text at original site
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引用元：
https://doi.org/10.1007/s11373-005-9067-1

データ提供：米国国立医学図書館（NLM）

Adefovir: A Journey Through the Liver

The liver is a complex and vital organ, a bustling desert oasis in the human body. This research investigates the effects of adefovir, an antiviral drug, on the cytochrome P450 system in rat liver microsomes. The authors explore the potential for adefovir to interfere with drug metabolism, examining its impact on the activity and expression of specific cytochrome P450 enzymes. This research provides valuable insights into the potential drug interactions that can occur with adefovir, highlighting the importance of careful drug monitoring and management.

Navigating the Desert of Drug Metabolism: Adefovir's Impact on the Liver

This research explores the potential of adefovir to interfere with drug metabolism, providing valuable insights into its impact on the cytochrome P450 system. The authors demonstrate that adefovir can influence the activity and expression of specific cytochrome P450 enzymes, highlighting the importance of careful drug monitoring and management.

Understanding Drug Interactions: A Vital Journey Through the Liver

The liver is a critical desert oasis in the human body, responsible for metabolizing drugs and removing harmful substances. This research provides valuable insights into the potential drug interactions that can occur with adefovir, emphasizing the importance of understanding these interactions for ensuring safe and effective drug therapy.

Dr.Camel's Conclusion

This research highlights the importance of understanding the potential drug interactions that can occur with antiviral medications like adefovir. It emphasizes the need for careful drug monitoring and management to ensure safe and effective treatment outcomes.

Date :
  1. Date Completed 2006-08-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16416053

DOI: Digital Object Identifier

10.1007/s11373-005-9067-1

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Languages

English

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