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Antivirals for influenza in healthy adults: systematic review.

Author: DemicheliV, Di PietrantonjC, JeffersonT, JonesM, RivettiA, RivettiD

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Amantadine and rimantadine should be discouraged. Neuraminidase inhibitors should not be used in seasonal influenza control and should only be used in a serious epidemic or pandemic.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Use of antivirals is recommended for the control of seasonal and pandemic influenza. Our aim was to review the evidence of efficacy, effectiveness, and safety of registered antivirals against naturally occurring influenza in healthy adults. METHODS: We searched various Databases to Octo...See full text at original site
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引用元：
https://doi.org/10.1016/S0140-6736(06)67970-1

データ提供：米国国立医学図書館（NLM）

Antivirals for Influenza: A Critical Review

This comprehensive review takes a deep dive into the vast desert of antiviral therapies for influenza, evaluating the efficacy, effectiveness, and safety of various antiviral drugs against naturally occurring influenza in healthy adults. The authors conducted a systematic review of randomized controlled trials published up to October 2005, analyzing data from 52 trials. The findings highlight the efficacy of amantadine and neuraminidase inhibitors (oseltamivir and zanamivir) in preventing and treating influenza. However, the review also emphasizes the limitations and potential adverse effects of these drugs. The authors conclude that amantadine should be discouraged due to its low effectiveness and adverse effects, while neuraminidase inhibitors should be reserved for serious epidemics or pandemics.

Neuraminidase Inhibitors Offer Limited Efficacy and Potential Side Effects

The review reveals that neuraminidase inhibitors, while offering some protection against influenza, have limited efficacy and potential side effects. The study found that neuraminidase inhibitors were not effective in preventing influenza-like illness or asymptomatic influenza. Furthermore, the study highlighted potential side effects like nausea, especially at higher doses. These findings suggest that neuraminidase inhibitors should be used cautiously and only in specific circumstances.

Navigating the Influenza Season with Antiviral Therapies

This review provides valuable insights for navigating the influenza season. While antiviral therapies can play a role in managing influenza, it is crucial to understand their limitations and potential risks. The study recommends using these therapies judiciously, only in serious epidemics or pandemics, and in conjunction with other public health measures. It's like a camel carefully navigating a desert landscape, choosing the right path to avoid hazards and reach its destination.

Dr. Camel's Conclusion

This study, like a well-equipped camel navigating a desert, offers a comprehensive overview of antiviral therapies for influenza. The review highlights both the potential benefits and limitations of current antiviral drugs, emphasizing the importance of judicious use and the need for ongoing research to develop more effective and safe therapies for influenza.

Date :
  1. Date Completed 2006-02-16
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

16443037

DOI: Digital Object Identifier

10.1016/S0140-6736(06)67970-1

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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