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Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence.
Author: ConnorJason P, DeanAngela J, JonesRod T, LawfordBruce R, SaundersJohn B, YoungRoss M
Original Abstract of the Article :
OBJECTIVE: Dysphoria and depression have been cited as side effects of the opioid antagonist naltrexone. We aimed to assess whether depressive symptoms are a clinically relevant side effect in a population receiving naltrexone as a treatment for opioid dependence. METHODS: We carried out a randomiz...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325065/
データ提供:米国国立医学図書館(NLM)
Naltrexone: A Controversial but Promising Treatment for Opioid Dependence
The field of addiction medicine is constantly striving to develop effective treatments for opioid dependence, a complex and often challenging condition. This study investigates the potential for naltrexone, an opioid antagonist, to induce depressive symptoms, a controversial issue that has raised concerns about its use. The researchers conduct a randomized controlled trial comparing naltrexone treatment with continued methadone maintenance, a common treatment for opioid dependence.
Naltrexone: A Beacon of Hope in the Desert of Addiction
The study provides reassuring findings. It reveals that naltrexone treatment is not associated with worsening depressive symptoms. In fact, the researchers find a trend towards improvement in depressive symptoms over time in participants who receive naltrexone. This is like finding a refreshing oasis in the desert of addiction, offering hope and relief for those struggling with opioid dependence.
Navigating the Challenges of Opioid Dependence: A Holistic Approach
This study highlights the importance of carefully considering the potential benefits and risks of different treatment options for opioid dependence. It underscores the need for open communication with healthcare professionals and for ongoing monitoring for potential side effects, particularly depressive symptoms.
Dr.Camel's Conclusion
This study provides valuable insights into the safety and efficacy of naltrexone in treating opioid dependence. It dispels the misconception that naltrexone induces depression and highlights its potential as a valuable treatment option, offering hope to those seeking to overcome this debilitating condition.
Date :
- Date Completed 2006-03-21
- Date Revised 2018-12-24
Further Info :
English
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