Side Effects of nedosiran injection: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Main Research Findings

Dysphoria and depression have been reported as side effects of the opioid antagonist naltrexone. This study aimed to assess whether depressive symptoms are a clinically relevant side effect in a population receiving naltrexone as a treatment for opioid dependence. 1

Reasons for side effects

Naltrexone is a medication that blocks the effects of opioids by binding to opioid receptors. This action can be effective in treating opioid dependence, but it can also cause opioid withdrawal symptoms. Withdrawal symptoms can include mental symptoms such as dysphoria and depression. 1

Common side effects

Dysphoria

Naltrexone can cause withdrawal symptoms such as dysphoria. 1

Depression

Naltrexone can cause mental withdrawal symptoms such as depression. 1

Side effects countermeasures

Dysphoria

If the dysphoria caused by naltrexone is mild, it can be alleviated by adjusting the dosage of the medication or by combining it with other medications. 1

Depression

If the depression caused by naltrexone is severe, treatment by a psychiatrist may be necessary. 1

Comparison between studies

Common points of studies

This study suggests that naltrexone administration is effective in treating opioid dependence. 1

Differences in studies

This study suggests that naltrexone administration may cause depressive symptoms in some patients. 1

Precautions for application in real life

Naltrexone is an effective medication for treating opioid dependence, but it can cause mental side effects such as dysphoria and depression. Therefore, when taking naltrexone, it is important to always follow your doctor's instructions and never stop taking it or change the dosage without consulting your doctor. 1

Limitations of current research

This study suggests that naltrexone administration may cause depressive symptoms in some patients, but further research is needed to clarify the mechanism by which depressive symptoms develop and the specific risk factors for depressive symptoms caused by naltrexone administration. 1

Future research directions

Further research is needed to clarify the mechanism by which depressive symptoms develop and the specific risk factors for depressive symptoms caused by naltrexone administration. 1

Conclusion

Naltrexone is an effective medication for treating opioid dependence, but it can cause mental side effects such as dysphoria and depression. When taking naltrexone, it is important to always follow your doctor's instructions and never stop taking it or change the dosage without consulting your doctor. 1

Keywords
Benefit Keywords
Reduce depression
1
Risk Keywords
Literature analysis of 1 papers
Positive Content
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Neutral Content
0
Negative Content
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Article Type
1
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1
1.

Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence.

Author: DeanAngela J, SaundersJohn B, JonesRod T, YoungRoss M, ConnorJason P, LawfordBruce R

Reduce depression

Naltrexone treatment did not exhibit worsening of depressive symptoms and a trend for improvement in depression was observed in participants attending all follow-up assessments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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