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Uridine abrogates the adverse effects of antiretroviral pyrimidine analogues on adipose cell functions.

Author: AuclairMartine, CapeauJacqueline, CaronMartine, KornprobstMichel, LebrechtDirk, WalkerUlrich A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Uridine supplementation protects adipocytes from the adverse effects of stavudine, zidovudine, and zalcitabine on lipid accumulation, cell survival, and mitochondrial functions. Uridine may be an interesting candidate for the prevention of NRTI-induced lipoatrophy in vivo.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Side effects of antiretroviral treatment such as lipoatrophy have been mainly attributed to mitochondrial toxicity of nucleoside reverse transcriptase inhibitors (NRTIs). We assessed whether uridine can abrogate the adverse effects of NRTIs on adipocyte functions. METHODS: 3T3-F442A pre...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/16518957

データ提供：米国国立医学図書館（NLM）

Uridine: A Potential Countermeasure to Antiretroviral Side Effects

Antiretroviral therapy has revolutionized the treatment of HIV infection, but it can also lead to side effects, including lipoatrophy, a condition characterized by fat loss. This research investigates the potential of uridine supplementation to mitigate the adverse effects of antiretroviral pyrimidine analogues on adipocyte function. The authors demonstrate that uridine can effectively protect adipocytes from the toxic effects of these drugs, offering a potential strategy for reducing lipoatrophy and improving patient well-being.

A Promising Avenue for Antiretroviral Management

The study's findings are promising, demonstrating that uridine supplementation can effectively counter the adverse effects of antiretroviral pyrimidine analogues on adipocyte function. This research highlights the importance of exploring strategies to mitigate the side effects of antiretroviral therapy, ensuring that patients can benefit from these life-saving treatments without experiencing significant adverse consequences.

A Holistic Approach to HIV Care

This research emphasizes the importance of a holistic approach to HIV care, addressing not only the viral infection but also the potential side effects of treatment. The authors' findings highlight the potential of uridine supplementation to improve patient outcomes and enhance the overall quality of life for individuals living with HIV.

Dr. Camel's Conclusion

This research provides valuable insights into the potential of uridine supplementation to mitigate the adverse effects of antiretroviral pyrimidine analogues on adipocyte function. The authors' findings offer hope for reducing lipoatrophy and improving patient well-being, highlighting the importance of exploring strategies to minimize the side effects of antiretroviral therapy and ensure that patients can benefit from these life-saving treatments without experiencing significant adverse consequences.

Date :
  1. Date Completed 2006-04-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16518957

DOI: Digital Object Identifier

16518957

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