Etanercept treatment in adults with established rheumatoid arthritis: 7 years of clinical experience.

Author: KeystoneEdward C, KremerJoel M, MartinRichard W, MorelandLarry W, SchiffMichael H, WeinblattMichael E, WhiteBarbara W, WhitmoreJames B

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate safety and efficacy of longterm etanercept treatment in patients with disease modifying antirheumatic drug (DMARD) refractory rheumatoid arthritis (RA). METHODS: Safety results are reported for 714 patients who received etanercept in one of 7 initial trials or a longterm exte...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/16541481

データ提供:米国国立医学図書館(NLM)

Long-Term Etanercept Treatment for Rheumatoid Arthritis: A Favorable Profile

Rheumatoid arthritis (RA), a chronic inflammatory disease, can significantly impact patients' quality of life. This study evaluates the safety and efficacy of long-term etanercept treatment, a tumor necrosis factor (TNF) inhibitor, in patients with RA refractory to conventional disease-modifying antirheumatic drugs (DMARDs). The researchers analyzed data from 714 patients who participated in initial trials and a long-term extension, with the longest individual treatment duration reaching 8.2 years. They found that etanercept exhibited a consistent safety profile, with rates of adverse events similar to those reported for patients with RA in general. Moreover, etanercept demonstrated durable clinical responses in many patients, with sustained improvements in disease activity and functional status for up to 7 years. This study provides robust evidence supporting the long-term safety and efficacy of etanercept as a therapeutic option for RA, offering hope for patients seeking sustained symptom relief and improved quality of life.

Long-Term Etanercept Treatment: A Beacon of Hope for RA Patients

This study provides compelling evidence supporting the long-term safety and efficacy of etanercept in treating rheumatoid arthritis. The sustained improvements in disease activity and functional status observed in patients over a 7-year period demonstrate the potential for long-term symptom relief and improved quality of life. This research underscores the importance of carefully considering the long-term benefits and risks of biologic therapies in managing chronic inflammatory diseases.

The Desert of Rheumatoid Arthritis: Finding Oasis with Etanercept

Just as a camel relies on oases for hydration and sustenance in the desert, RA patients seeking relief can find solace in effective treatments like etanercept. This study demonstrates the potential for sustained symptom improvement and improved quality of life through long-term etanercept therapy. The findings highlight the importance of finding the right oasis for individual patients, enabling them to navigate the challenges of RA with greater ease and comfort.

Dr. Camel's Conclusion

This study demonstrates the long-term safety and efficacy of etanercept in treating rheumatoid arthritis. The consistent safety profile and durable clinical responses observed in patients over a 7-year period offer a beacon of hope for patients seeking sustained symptom relief and improved quality of life. These findings underscore the importance of carefully considering the long-term benefits and risks of biologic therapies in managing chronic inflammatory diseases.
Date :
  1. Date Completed 2006-08-09
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

16541481

DOI: Digital Object Identifier

06/13/038

Related Literature

SNS
PICO Info
in preparation
Languages

English

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