Paper Details

  1. Home
  2. Paper Details

Thiazide diuretics in the treatment of hypertension: an update.

Author: GhiadoniLorenzo, SalvettiAntonio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Thiazide diuretics were the first effective and well-tolerated antihypertensive drugs. While still considered a cornerstone of hypertension treatment, several considerations are important. While chlorthalidone may offer additional benefits, the overall effect of thiazide diuretics appears to be class-specific. Optimal doses are essential to balance effectiveness and side effects, including glucose and lipid profile alterations and hypokalemia. Thiazides can increase new-onset diabetes risk, especially when combined with beta-blockers. Therefore, thiazides should be used cautiously in high-risk individuals, at the lowest effective dose, and potentially combined with renin-angiotensin system blockers. While the Seventh Joint National Committee Report suggests thiazides as the first-choice drug for most hypertensive patients, the European Society of Hypertension-European Society of Cardiology Guidelines include them among other suitable classes for initiating and maintaining treatment. This discrepancy stems from differing interpretations of clinical trial data and cost-benefit analyses. However, given the lack of evidence supporting one specific class as superior, thiazides should not be solely considered as the first-choice drug, but included among first-line options.
Paper Details　
Original Abstract of the Article :
Thiazide diuretics were the first tolerated efficient antihypertensive drugs that significantly reduced cardiovascular morbidity and mortality in placebo-controlled clinical studies. Although these drugs today still are considered a fundamental therapeutic tool for the treatment of hypertensive pati...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1681/ASN.2005121329

データ提供：米国国立医学図書館（NLM）

Thiazide Diuretics: Navigating the Sands of Hypertension

Hypertension, or high blood pressure, is like a relentless desert wind, putting a strain on the cardiovascular system. Thiazide diuretics, like a reliable caravan, have been a cornerstone of hypertension treatment for decades, effectively reducing cardiovascular risks.

This study, like a seasoned guide, provides an update on the use of thiazide diuretics in treating hypertension. It emphasizes the importance of using these drugs at optimal doses to maximize their benefits while minimizing potential side effects. The authors also discuss the complexities of using these drugs in high-risk patients and the ongoing debate about their place in the first-line treatment of hypertension.

The study suggests that thiazide diuretics, while valuable, should be considered among a broader range of antihypertensive drugs, rather than being the only first-choice option.

A Balanced Approach to Hypertension Treatment

This research suggests that while thiazide diuretics remain a valuable tool in hypertension management, they should be used strategically and in combination with other treatments. This balanced approach, like the careful selection of routes and resources in a desert expedition, is crucial for achieving optimal outcomes and reducing potential risks.

Navigating the Desert of Hypertension

If you are diagnosed with hypertension, it's vital to consult with a qualified healthcare professional. They can guide you through the complexities of treatment options, considering your individual needs and risk factors, just as a seasoned guide would lead a caravan through a challenging landscape. Together, you can develop a personalized treatment plan that ensures optimal management of your condition, leading to a healthier and more fulfilling life.

Dr.Camel's Conclusion

This research provides a comprehensive review of thiazide diuretics in the management of hypertension. It underscores the importance of individualized care, considering patient factors, and employing a multi-faceted approach to treatment. Like navigating a vast desert, managing hypertension requires a blend of knowledge, experience, and careful planning to achieve long-term health and well-being.

Date :
  1. Date Completed 2007-01-12
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

16565243

DOI: Digital Object Identifier

10.1681/ASN.2005121329

Related Literature

Article Analysis
・Side Effects of chlorthalidone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.