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Discrete cues paired with naloxone-precipitated withdrawal from acute morphine dependence elicit conditioned withdrawal responses.

Author: AmitaiNurith, LiuJian, SchulteisGery

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Morphine induces acute opioid dependence, as evidenced by naloxone-precipitated withdrawal. Repeated morphine exposure and withdrawal experiences intensify withdrawal severity. This study investigated whether conditioned withdrawal responses could be elicited by a discrete tone/light conditioned stimulus in rats with acute opioid dependence. Presenting the conditioned stimulus alone reliably suppressed responding in the paired group compared to control groups. This suggests that conditioned withdrawal can be established to discrete cues associated with naloxone-precipitated withdrawal from acute, infrequent opioid exposure.
Paper Details　
Original Abstract of the Article :
Acute bolus doses of morphine induce a state of acute opioid dependence as measured by naloxone-precipitated withdrawal. Repeated morphine and precipitated withdrawal experience further enhances naloxone-induced withdrawal severity, partly because of direct neuroadaptation to repeated morphine, and ...See full text at original site
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引用元：
https://doi.org/10.1097/00008877-200605000-00002

データ提供：米国国立医学図書館（NLM）

The Power of Association: Conditioned Withdrawal in Morphine Dependence

The field of Opioid Dependence is a complex and challenging area, where researchers strive to understand the underlying mechanisms of addiction and develop effective treatments. This study delves into the fascinating phenomenon of conditioned withdrawal, exploring how specific cues can trigger withdrawal symptoms in rats with acute morphine dependence. The researchers paired a tone/light stimulus with naloxone-precipitated withdrawal, simulating the environmental triggers that can contribute to relapse in individuals with opioid dependence.

Conditioned Withdrawal: A Powerful Trigger

The study's findings demonstrate that repeated morphine injections, followed by naloxone-induced withdrawal, lead to the establishment of conditioned withdrawal responses. This means that the rats developed an association between the tone/light stimulus and the unpleasant withdrawal symptoms. The researchers observed that the conditioned stimulus alone was sufficient to elicit withdrawal responses, even in the absence of morphine. This finding highlights the powerful influence of environmental cues in triggering cravings and relapse in individuals with opioid dependence.

Navigating the Desert of Addiction: Understanding the Mechanisms

Understanding the mechanisms behind conditioned withdrawal is crucial for developing effective strategies to manage opioid dependence. By recognizing the role of environmental cues, clinicians can help individuals avoid triggers that can lead to relapse. This knowledge is essential for navigating the complex desert of addiction, guiding individuals towards a path of recovery.

Dr. Camel's Conclusion

Just as the desert landscape is dotted with landmarks that serve as guides for travelers, this study reveals that environmental cues can be powerful triggers for relapse in opioid dependence. The researchers' findings highlight the importance of understanding and managing these conditioned withdrawal responses in the pursuit of effective addiction treatment.

Date :
  1. Date Completed 2006-10-19
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

16571999

DOI: Digital Object Identifier

10.1097/00008877-200605000-00002

Related Literature

Article Analysis
・Effects of naloxone injection
SNS
PICO Info
in preparation
Languages

English

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