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Effects of the potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants.

Author: ClarkH Fred, DallasMichael J, DiNubileMark J, DiStefanoDaniel J, DrummondJames E, GoveiaMichelle G, HeatonPenny M, KarvonenAino, OffitPaul A, SchödelFlorian, VesikariTimo, WardRichard L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study evaluated different compositions and potencies of a live multivalent human-bovine reassortant rotavirus vaccine to select the best potency and composition for further development.
Paper Details　
Original Abstract of the Article :
Rotavirus gastroenteritis, which causes substantial infant mortality and morbidity worldwide, is a vaccine-preventable disease. The purpose of this study was to evaluate different compositions and potencies (vaccine virus titers) of a live multivalent human-bovine (WC3) reassortant rotavirus vaccine...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.vaccine.2006.03.025

データ提供：米国国立医学図書館（NLM）

Effects of the Potency and Composition of the Multivalent Human-Bovine (WC3) Reassortant Rotavirus Vaccine on Efficacy, Safety and Immunogenicity in Healthy Infants

This study explores the world of vaccine development, focusing on a novel rotavirus vaccine, a multivalent human-bovine (WC3) reassortant vaccine. The authors meticulously evaluate different compositions and potencies of this vaccine, seeking to optimize its efficacy, safety, and immunogenicity in healthy infants.

Optimizing Rotavirus Vaccine Efficacy

The study delves into the intricate process of vaccine development, akin to a camel caravan carefully selecting the best route across a vast desert. The researchers meticulously evaluate different vaccine formulations to determine the most effective and safe approach to protecting infants from rotavirus infection.

Protecting Infants from Rotavirus

Rotavirus gastroenteritis is a major cause of infant mortality and morbidity worldwide, making the development of effective and safe vaccines a top priority. This research contributes to the global effort to combat this devastating disease.

Dr. Camel's Conclusion

This study represents a crucial step in the ongoing pursuit of safe and effective vaccines for infants. The researchers' meticulous evaluation of different vaccine formulations is a testament to their dedication to protecting the most vulnerable members of our society.
Date :
  1. Date Completed 2006-08-09
  2. Date Revised 2006-06-01
Further Info :

Pubmed ID

16621194

DOI: Digital Object Identifier

10.1016/j.vaccine.2006.03.025

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Article Analysis
・Effects of rotavirus vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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