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Comparative beta-adrenoceptor blocking effects and pharmacokinetics of penbutolol and propranolol in man.

Author: BerdeauxA, ChauvinM, GiudicelliJ F, IdrissiN, RicherC

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Penbutolol, a non-cardioselective beta-blocker, was more potent than propranolol in antagonizing exercise-induced tachycardia, reducing exercise-induced increase in PEFR, and decreasing PRA. Penbutolol is transformed into an active metabolite in humans.
Paper Details　
Original Abstract of the Article :
1 The beta-adrenoceptor blocking effects of penbutolol were compared with those of propranolol and a placebo in a double-blind trial involving six healthy volunteers. 2 Heart rate (HR), systolic blood pressure (SBP) and peak expiratory flow rate (PEFR) were measured at rest and during vigorous exerc...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1977.tb00684.x

データ提供：米国国立医学図書館（NLM）

Penbutolol and Propranolol: A Comparative Journey Through the Desert of Beta-Blockers

The world of beta-blockers, like a vast desert landscape, offers different pathways for managing heart health. This study compares the effects of penbutolol and propranolol, two beta-blockers, on healthy volunteers. Researchers conducted a double-blind trial, comparing the effects of both drugs to a placebo.

The researchers found that penbutolol, like a swift camel traversing a sand dune, had a faster and more pronounced effect on heart rate and blood pressure than propranolol, which is like a slower-paced camel meandering across the desert.

Penbutolol: A Potentially More Effective Beta-Blocker

These findings suggest that penbutolol might be a more potent beta-blocker than propranolol, but it's crucial to remember that this study focused on healthy volunteers, and further research is needed to confirm these findings in patients with specific medical conditions.

Navigating the Desert of Beta-Blockers

Beta-blockers are a common class of medications used for managing heart conditions, but it's important to consult with a healthcare professional to determine if they're right for you. It's essential to understand the potential side effects of any medication and to monitor your response closely.

Dr.Camel's Conclusion

This study offers a glimpse into the comparative effects of penbutolol and propranolol. It's a reminder that even within a single class of medications, there can be significant differences in how they work. It's important to consult with a healthcare professional to find the best approach for your individual needs.

Date :
  1. Date Completed 1977-07-29
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

16632

DOI: Digital Object Identifier

10.1111/j.1365-2125.1977.tb00684.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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