Effects of penciclovir cream: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Main Research Findings

Penciclovir cream has been shown to be an effective treatment for herpes simplex virus (HSV) infections in multiple studies. 6 , 8 , 10 , 11 , 7 . Penciclovir cream has been shown to be effective in reducing the duration of herpes lesions and pain. 8 , 11 . Penciclovir cream has been shown to be effective in reducing viral shedding, which can help to prevent the spread of infection. 8 . Penciclovir cream has been shown to be effective in treating both oral and genital herpes. 6 , 8 , 10 , 11 , 7 . Penciclovir cream has been shown to be effective in treating herpes labialis induced by sunlight. 11 . The prevalence of resistance to penciclovir is similar to that of acyclovir. 6 .

Benefits and Risks

Benefit Summary

Penciclovir cream has been shown to be effective in treating herpes simplex virus infections. It has been shown to reduce the duration of lesions, pain, and viral shedding. 8 , 11 . It has been shown to be effective in treating both oral and genital herpes. 6 , 8 , 10 , 11 , 7 .

Risk Summary

Penciclovir cream is generally considered safe. However, some patients may experience mild side effects such as skin irritation or rash. 10 .

Comparison between Studies

Commonalities of Studies

These studies consistently demonstrate that penciclovir cream is effective in treating herpes simplex virus infections. These studies conclude that penciclovir cream is effective in treating herpes simplex virus infections compared to acyclovir cream. 10 , 7 . These studies conclude that penciclovir cream is generally safe. 10 .

Differences between Studies

These studies utilize different research designs to evaluate the effectiveness of penciclovir cream. For example, some studies compare penciclovir cream to acyclovir cream. 10 , 7 . Other studies compare penciclovir cream to placebo. 11 . These studies target different types of herpes simplex virus infections. For example, some studies target oral herpes. 6 , 8 , 11 , 7 . Other studies target genital herpes. 10 . These studies have different dosage regimens for penciclovir cream. For example, some studies apply penciclovir cream 5 times per day. 10 . Other studies apply penciclovir cream 2 times per day. 11 .

Consistency and Inconsistencies of the Results

These studies consistently demonstrate that penciclovir cream is effective in treating herpes simplex virus infections. However, there is some variability in the results regarding the effectiveness and safety of penciclovir cream. This could be due to the different research designs, patient populations, and dosage regimens used in the studies. 6 , 8 , 10 , 11 , 7 .

Important Considerations for Practical Applications

Penciclovir cream is an effective treatment for herpes simplex virus infections. If you experience herpes symptoms, consult with your doctor to obtain a prescription for penciclovir cream. When using penciclovir cream, follow your doctor's instructions carefully. Penciclovir cream is generally safe, but some patients may experience side effects. If you experience any side effects, consult with your doctor. 6 , 8 , 10 , 11 , 7 .

Limitations of Current Research

More research is needed to further evaluate the effectiveness and safety of penciclovir cream. In particular, more research is needed on the long-term use of penciclovir cream. Further research is needed to assess whether penciclovir cream has an effect on viral load. 6 , 8 , 10 , 11 , 7 .

Future Research Directions

Larger studies are needed to further evaluate the effectiveness and safety of penciclovir cream. More research is needed on the long-term use of penciclovir cream. Further research is needed to assess whether penciclovir cream has an effect on viral load. 6 , 8 , 10 , 11 , 7 .

Conclusion

Penciclovir cream is considered an effective treatment option for herpes simplex virus infections. It is generally safe, but some patients may experience mild side effects. If you experience herpes symptoms, consult with your doctor about the possibility of penciclovir cream as a treatment option. 6 , 8 , 10 , 11 , 7 .

Literature analysis of 12 papers
Positive Content
11
Neutral Content
1
Negative Content
0
Article Type
9
0
0
1
12
1.

Comparative beta-adrenoceptor blocking effects and pharmacokinetics of penbutolol and propranolol in man.

Author: GiudicelliJ F, RicherC, ChauvinM, IdrissiN, BerdeauxA

Beta-adrenoceptor blocking effect

Penbutolol, a non-cardioselective beta-blocker, was more potent than propranolol in antagonizing exercise-induced tachycardia and reducing peak expiratory flow rate. Its half-life was 4.5 hours. Penbutolol was transformed into an active metabolite after oral administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Treatment of essential mild-to-moderate arterial hypertension with once-daily penbutolol. Controlled clinical study vs atenolol].

Author: NamiR, MartinelliM, BianchiniC, GennariC

Effective for hypertension
Well tolerated
No significant risks mentioned

Penbutolol, a non-selective beta-blocker with an ISA effect, was as effective as atenolol, a cardioselective beta-blocker without ISA effect, in controlling blood pressure in 40 patients with mild-to-moderate essential hypertension. Penbutolol was better tolerated than atenolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

3.

Pharmacodynamic and pharmacokinetic study of oral and intravenous penbutolol.

Author: VedinJ A, WilhelmssonC, MaassL, PetersonL E

Lowers exercise heart rate
Lowers exercise systolic pressure
Well tolerated

Penbutolol is well-tolerated and effectively reduces heart rate and blood pressure after intravenous and oral administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Penbutolol or hydrochlorothiazide once a day in hypertension. A controlled study with home measurements.

Author: De PlaenJ F, Vander ElstE, Van Ypersele de StrihouC

Effective for hypertension
Long lasting effect
Well tolerated
Hyperuricemia
Hypokalemia

Penbutolol was more effective in reducing blood pressure than hydrochlorothiazide in 10 hypertensive patients. The hypotensive effect lasted for 24 hours. No significant side effects were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Use of fixed doses of beta blocking drugs in the treatment of hypertension. Randomised study of atenolol and penbutolol.

Author: LameijerL D, VoermansL A, HoutzagersJ J, ChadhaD R

Effective for hypertension
Well tolerated
Bradycardia

Both atenolol and penbutolol were effective in controlling moderate hypertension in 45 patients. Atenolol was associated with more frequent bradycardia, while penbutolol may be useful for patients who experience bradycardia with other beta-blockers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Penciclovir susceptibilities of herpes simplex virus isolates from patients using penciclovir cream for treatment of recurrent herpes labialis.

Author: SariskyRobert T, BaconTeresa, BoonRon, LockeLeslie, NguyenTammy T, LearyJeffry, EsserKlaus, SaltzmanRobin

Antiherpesvirus
Herpes labialis
PCV resistance

Penciclovir, an antiherpesvirus agent, was effective in treating recurrent herpes labialis, with only a low prevalence of resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Topical application of penciclovir cream for the treatment of herpes simplex facialis/labialis: a randomized, double-blind, multicentre, aciclovir-controlled trial.

Author: LinL, ChenX S, CuiP G, WangJ B, GuoZ P, LuN Z, BiZ G, JiaH, YangX Y,

Improved clinical course

Topical 1% penciclovir cream is as convenient and as effective as 3% aciclovir cream for the treatment of HSFL.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials.

Author: RabornG Wayne, MartelAlain Y, LassondeMichel, LewisMichael A O, BoonRon, SpruanceSpotswood L,

Herpes simplex labialis treatment
Lesion pain reduction

Topical penciclovir cream was significantly more effective than placebo in healing classical lesions and resolving pain associated with recurrent herpes simplex labialis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Comparison of new topical treatments for herpes labialis: efficacy of penciclovir cream, acyclovir cream, and n-docosanol cream against experimental cutaneous herpes simplex virus type 1 infection.

Author: McKeoughM B, SpruanceS L

This abstract reviewed three new topical treatments for herpes labialis: penciclovir cream, n-docosanol cream, and acyclovir cream.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

A comparison of topical application of penciclovir 1% cream with acyclovir 3% cream for treatment of genital herpes: a randomized, double-blind, multicentre trial.

Author: ChenX S, HanG Z, GuoZ P, LuN Z, ChenJ, WangJ B,

Faster crusting
Improved herpes symptoms
Mild adverse effects

This randomized, double-blind, multicentre trial compared the efficacy of penciclovir 1% cream to acyclovir in treating genital herpes simplex virus (HSV) infection. The study found that penciclovir showed encouraging results, with a shorter time to crusting in patients with primary infections, but no significant differences in overall efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Penciclovir cream for the treatment of sunlight-induced herpes simplex labialis: a randomized, double-blind, placebo-controlled trial. Penciclovir Cream Herpes Labialis Study Group.

Author: BoonR, GoodmanJ J, MartinezJ, MarksG L, GambleM, WelchC

Herpes labialis treatment
Penciclovir cream efficacy

Penciclovir cream was effective in treating sunlight-induced herpes labialis, significantly decreasing the time to lesion healing and reducing lesion-associated symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Treatment of Herpes simplex virus infections with topical antiviral agents.

Author: HamuyR, BermanB

Treats HSV infections

This review summarizes clinical studies of topical therapy for Herpes simplex virus infections. Idoxuridine (IDU) 15% in dimethyl sulfoxide (DMSO), interferons, and penciclovir demonstrate significant clinical benefit. Penciclovir cream reduced the duration of lesions, pain, and viral shedding in a study of over 2,000 patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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