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Effect of thioridazine on gap junction intercellular communication in connexin 43-expressing cells.

Author: AbifadelD N, GarciaE L, JannM W, MatesicD F

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study tested the effect of thioridazine and mesoridazine on gap junction-mediated intercellular communication between cells. The drugs inhibited gap junction-mediated intercellular communication, which may contribute to the cardiac side-effects observed in patients taking these medications.
Paper Details　
Original Abstract of the Article :
Propagation of electrical activity between myocytes in the heart requires gap junction channels, which contribute to coordinated conduction of the heartbeat. Some antipsychotic drugs, such as thioridazine and its active metabolite, mesoridazine, have known cardiac conduction side-effects, which have...See full text at original site
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引用元：
https://doi.org/10.1007/s10565-006-0047-7

データ提供：米国国立医学図書館（NLM）

Thioridazine's Impact on Heart Cell Communication

The heart is a symphony of coordinated muscle contractions, enabled by intricate communication between individual heart cells. This research delves into the fascinating world of gap junction channels, the tiny pathways that allow heart cells to communicate and ensure a rhythmic beat. The study focuses on thioridazine, an antipsychotic drug known to have cardiac side effects. Researchers investigated how thioridazine affects the function of gap junction channels, particularly those formed by connexin 43, a protein essential for heart cell communication.

Disrupting the Heart's Symphony: Thioridazine's Influence on Gap Junctions

The study revealed that thioridazine, at clinically relevant concentrations, inhibits gap junction communication between cells expressing connexin 43. This disruption could potentially explain the cardiac side effects observed in some patients taking this medication. Think of thioridazine as a mischievous desert wind, interfering with the delicate symphony of communication between heart cells, potentially leading to disruptions in the heart's rhythm.

A Cautionary Tale for Patients: Understanding Potential Side Effects

This research serves as a reminder of the importance of understanding the potential side effects of medications, even those used for mental health conditions. While thioridazine can be effective for certain psychiatric conditions, it's crucial to monitor for any cardiac symptoms and discuss them with your doctor promptly. It's always wise to approach medication with a discerning eye and discuss any concerns with your healthcare provider.

Dr.Camel's Conclusion

This research emphasizes the intricate relationship between drugs and the body's delicate systems, particularly in the context of cardiac health. By understanding the potential impact of medications on heart cell communication, we can better manage the risks associated with their use. Like navigating a treacherous desert, understanding the terrain of our own physiology is crucial for maintaining our well-being.

Date :
  1. Date Completed 2007-02-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16685461

DOI: Digital Object Identifier

10.1007/s10565-006-0047-7

SNS
PICO Info
in preparation
Languages

English

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