A double-blind, placebo- and flurazepam-controlled investigation of the residual psychomotor and cognitive effects of modified release zolpidem in young healthy volunteers.

Author: AudebertChristine, BlinOlivier, LegangneuxEric, MicallefJoëlle

Paper Details 
Original Abstract of the Article :
Short-acting hypnotic drugs, such as zolpidem, have minimal residual effects but may not provide optimal efficacy throughout the night for all insomnia patients. A modified-release formulation of zolpidem, zolpidem-MR, has been developed to overcome this limitation. This was a phase I, double-blind,...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/16702893

データ提供:米国国立医学図書館(NLM)

Zolpidem: A Sleeping Giant with Minimal Residual Effects

Insomnia, the persistent inability to sleep, can be a debilitating condition. This study investigates the residual effects of a modified-release formulation of zolpidem, a common sleep medication. The researchers conducted a double-blind, placebo-controlled study on 18 young healthy volunteers, comparing the effects of zolpidem-MR to placebo and flurazepam, another hypnotic drug. They found that zolpidem-MR had minimal residual psychomotor and cognitive effects, suggesting that it may be a better option for individuals concerned about daytime drowsiness.

Finding a Balance Between Sleep and Wakefulness

Insomnia can be like a persistent desert wind, disrupting our rhythm and leaving us feeling exhausted and drained. This study explores the quest for a sleep medication that provides restful sleep without lingering effects. Zolpidem-MR appears to be a promising candidate, offering a more balanced approach to managing insomnia.

A New Approach to Sleep Management

This research highlights the potential benefits of modified-release formulations of sleep medications. By providing a more sustained release of the active ingredient, these medications may offer improved sleep quality with minimal carryover effects. It’s like finding a well-designed oasis in the desert – providing sustenance and refreshment without disrupting the journey.

Dr.Camel's Conclusion

This study suggests that zolpidem-MR might be a suitable option for individuals seeking a sleep medication with minimal residual effects. It’s like finding a comfortable and reliable camel for a desert journey – providing a smooth ride without leaving you feeling sluggish or exhausted. However, as with any medication, it’s important to consult with a healthcare professional to determine the most appropriate treatment plan.

Date :
  1. Date Completed 2006-08-10
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16702893

DOI: Digital Object Identifier

00004714-200606000-00009

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SNS
PICO Info
in preparation
Languages

English

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