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Toxicity, stability and pharmacokinetics of amphotericin B in immunomodulator tuftsin-bearing liposomes in a murine model.

Author: KhanMasood A, OwaisMohd

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Liposomal amphotericin B loaded with the immunomodulator tuftsin showed superior efficacy and safety compared to conventional amphotericin B in a murine model of Candida albicans infection. Tuftsin-loaded liposomes exhibited increased stability, reduced toxicity, and improved pharmacokinetics compared to tuftsin-free liposomes, suggesting its potential therapeutic value in treating fungal infections.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: In the present study we evaluated the pharmacokinetics and toxicity of amphotericin B in immunomodulator tuftsin-loaded liposomes in a murine model. METHODS: Stability of amphotericin B liposomes was tested by incubating one volume of liposomal formulations of amphotericin B with nine v...See full text at original site
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引用元：
https://doi.org/10.1093/jac/dkl177

データ提供：米国国立医学図書館（NLM）

Amphotericin B: A Powerful Antifungal with a New Delivery System

Amphotericin B, a powerful antifungal drug, is often used to treat serious fungal infections. However, it can also cause significant side effects. This study investigates the use of liposomes, tiny spheres that can deliver drugs to specific targets, to improve the safety and effectiveness of amphotericin B. This research delves into the exciting world of nanotechnology, exploring its potential to revolutionize drug delivery and treatment.

A Safer and More Effective Amphotericin B

The study demonstrates that encapsulating amphotericin B in liposomes, and even more so, in liposomes containing the immunomodulator tuftsin, significantly reduces the toxicity of the drug while maintaining its antifungal efficacy. This is a significant breakthrough, as it could potentially lead to a safer and more effective treatment for fungal infections.

The Future of Drug Delivery

This research highlights the potential of nanotechnology in improving drug delivery and treatment outcomes. Liposomes offer a promising platform for encapsulating and delivering drugs, reducing toxicity and improving efficacy. This is a testament to the power of innovation in addressing complex medical challenges.

Dr.Camel's Conclusion

This study demonstrates the promising potential of amphotericin B encapsulated in liposomes containing tuftsin. This approach significantly reduces the toxicity of the drug while maintaining its antifungal efficacy. This research highlights the innovative potential of nanotechnology in improving drug delivery and treatment outcomes.

Date :
  1. Date Completed 2006-09-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16709592

DOI: Digital Object Identifier

10.1093/jac/dkl177

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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