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Therapies for peripheral joint disease in psoriatic arthritis. A systematic review.

Author: McHughNeil J, SorianoEnrique R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review found that NSAIDs are effective for pain relief in psoriatic arthritis (PsA), but evidence for COX-2 inhibitors is limited. There's no evidence to support systemic or joint injections of steroids, despite their common use. Among traditional disease-modifying drugs, sulfasalazine, cyclosporine, and leflunomide have good evidence for pain relief, while methotrexate has weaker evidence. None of these slow joint damage. Anti-TNF drugs (etanercept, infliximab, and adalimumab) have strong evidence for improving symptoms, function, quality of life, and joint damage. The lack of evidence for some treatments makes developing treatment plans difficult.
Paper Details　
Original Abstract of the Article :
Traditional drug treatments for psoriatic arthritis (PsA) include nonsteroidal antiinflammatory agents (NSAID) and disease modifying antirheumatic drugs (DMARD), although the evidence base for their effectiveness is not well established. This review was compiled from a comprehensive literature searc...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/16724372

データ提供：米国国立医学図書館（NLM）

Treating Peripheral Joint Disease in Psoriatic Arthritis

This study reviews existing therapies for peripheral joint disease in psoriatic arthritis (PsA), a condition that affects both the skin and joints. The authors analyze the evidence for various traditional and biological treatments, seeking to establish a comprehensive approach for managing this complex condition. This review shines a light on the ever-evolving landscape of PsA treatment, guiding clinicians and researchers towards better therapies.

Traditional vs. Biological Therapies

The review found that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for symptom relief, but the evidence base for disease-modifying antirheumatic drugs (DMARDs) is less robust. Interestingly, anti-TNF antagonists, a type of biological therapy, showed promising results in improving symptoms, physical function, and radiographic progression.

Navigating the Shifting Sands of PsA Treatment

This review highlights the need for further research to refine treatment algorithms for peripheral joint disease in PsA. Like navigating a vast desert, finding the optimal treatment path for each patient requires careful consideration and a deep understanding of the latest evidence. This review serves as a compass, pointing towards future directions in PsA research.

Dr. Camel's Conclusion

This research offers a comprehensive review of existing therapies for PsA, helping us navigate the complex terrain of managing this condition. The study highlights the need for continued research and innovation to develop more effective and personalized treatment approaches. It reminds us that even in the seemingly barren landscapes of chronic illness, there are oases of hope waiting to be discovered.

Date :
  1. Date Completed 2006-11-07
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

16724372

DOI: Digital Object Identifier

06/13/0511

Related Literature

Article Analysis
・Effective treatment of psoriatic arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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