Effective treatment of psoriatic arthritis: A Synthesis of Findings from 108 Studies

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Original Abstract of the Article

Major Research Findings

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that affects people with psoriasis. It can cause inflammation in joints, skin, nails, tendons, and the spine. PsA can lead to a variety of symptoms that can significantly impact quality of life. While treatments for PsA have improved, finding effective and safe therapies remains a challenge. Several studies have shown the effectiveness of biologic agents like etanercept, infliximab, adalimumab, secukinumab, and ustekinumab as treatments for PsA. 63 , 16 , 62 , 68 , 70 . These biologics work by blocking the action of certain proteins called cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17), which are key drivers of inflammation. These therapies have been shown to be effective in reducing joint pain, swelling, and stiffness. 7 , 27 , 86 . Additionally, they have shown to slow the progression of PsA. 8 , 55 . However, biologics carry risks of infection and other side effects, so careful use is important. 74 , 71 . Treatment for PsA also includes traditional therapies such as nonsteroidal anti-inflammatory drugs (NSAIDs) and methotrexate. 49 . But these therapies often aren't as effective as biologics and can have higher risks of side effects. 4 .

Treatment Summary

PsA treatment involves a variety of approaches, including biologics, traditional therapies, and non-drug therapies. Biologics work by blocking cytokines like TNF-α and IL-17. Effective treatments include etanercept, infliximab, adalimumab, secukinumab, and ustekinumab. 16 , 62 , 68 , 70 , 78 . Traditional therapies utilize medications like NSAIDs and methotrexate. 49 . Non-drug therapies include exercise, physical therapy, and lifestyle modifications. 47 . 97 .

Benefits and Risks

Benefits Summary

Treatments for PsA provide several benefits, including reduced joint pain, swelling, and stiffness, as well as slowed progression of PsA. 8 , 7 , 27 , 55 .

Risks Summary

Treatments for PsA come with risks, such as infections, allergic reactions, liver problems, anemia, lymphoma, cardiovascular disease, and skin cancer. 40 , 74 , 71 .

Comparison of Studies

Similarities Between Studies

Many studies have demonstrated the effectiveness of biologic agents in alleviating PsA symptoms and slowing disease progression. 16 , 62 , 68 , 70 , 7 , 27 , 8 , 55 . However, it's important to use biologics cautiously because of the risk of infections and other side effects. 74 , 71 .

Differences Between Studies

The effectiveness and side effects of different biologics vary. Additionally, research comparing traditional therapies and biologics suggests that biologics are more effective. 4 .

Consistency and Contradictions in Findings

Research on PsA treatment tends to show the effectiveness of biologics while highlighting fewer studies demonstrating the efficacy of traditional therapies. Research on biologic side effects indicates a risk of infections and other adverse events. 74 , 71 .

Important Considerations for Real-Life Applications

PsA treatment involves a range of therapies. It's crucial to choose the best treatment for each patient based on their individual condition and symptoms. When selecting a treatment, it's important to discuss the benefits and risks with your doctor. 47 , 97 .

Limitations of Current Research

There's still a lot we don't know about PsA treatment, and more research is needed. This is especially true for long-term effectiveness and safety of biologics. 107 .

Directions for Future Research

Future research on PsA treatment should focus on developing more effective and safer therapies, evaluating the long-term effects and safety of biologics, and creating treatments that improve quality of life for patients. 75 , 30 .

Conclusion

PsA can cause a wide range of symptoms that can significantly affect quality of life. Treatments for PsA involve various approaches, including biologics, traditional therapies, and non-drug therapies. While treatments have improved, finding effective and safe therapies remains a challenge. Future research is needed to develop more effective and safer therapies, evaluate the long-term effects and safety of biologics, and create treatments that improve quality of life for patients.

Treatment List

Etanercept, infliximab, adalimumab, secukinumab, ustekinumab, methotrexate, nonsteroidal anti-inflammatory drugs (NSAIDs), exercise, physical therapy, lifestyle modifications

Keywords
Benefit Keywords
Improved psoriatic arthritis treatment
1
Effective treatment
2
Improved psoriatic arthritis and psoriasis treatment
3
Joint improvement
Pain reduction
4
Improvement in psoriatic skin lesions
Significant improvement in PsA signs and symptoms
5
Effective treatment of PsA
Improved psoriatic skin lesions
Well tolerated
6
Improved psoriasis lesions
Inhibited radiographic progression
Reduced PsA symptoms
7
Improved arthritis
Improved psoriasis
Inhibited radiographic progression
Well tolerated
8
PsA treatment
9
Improved dactylitis treatment
10
Improved axial PsA treatment
11
Improved psoriatic arthritis treatment
12
Improved psoriatic arthritis treatment
13
Improved PsA treatment
14
Improved psoriatic arthritis treatment
15
Effective for PsA
Reduces joint pain
16
Improved PsA treatment
17
PsA symptom reduction
Psoriasis improvement
18
Psoriatic arthritis treatment
19
Improved PsA treatment
20
Improved function
Improved quality of life
Reduced joint pain
21
Reduced MMP13 expression
Reduced T cell infiltration
22
Psoriatic arthritis treatment
23
Improved psoriasis and psoriatic arthritis
24
Psoriatic arthritis treatment
25
Early PsA diagnosis
26
PsA treatment
27
PA treatment
28
Cost-effective treatment
29
Joint Disease Reduction
PsA Treatment
Skin Disease Reduction
30
Improved PsA treatment
31
Treatment of psoriatic arthritis
32
Improved PASI
Improved PsA
33
Improved QoL
Improved skin symptoms
34
Improved PsA
35
Treatment of PsA
36
Psoriatic arthritis treatment
37
Nail psoriasis treatment
Psoriasis treatment
38
Improved clinical outcome
39
Potential for reduced cardiovascular events
40
PsA screening
Treatment response measurement
41
PsA treatment
42
PsA treatment
43
Etanercept treatment
Improved quality of life
44
PsA treatment
45
Arotinoid ethylesther efficacy
Excimer 308 nm efficacy
PPPP symptom relief
PUVA efficacy
46
PsA treatment
48
PsA treatment
49
PsA treatment
50
Certolizumab
Infliximab
Ustekinumab
52
PsA treatment
53
Improved QoL
Improved arthritis scores
55
Mud-bath therapy
56
PsA treatment
57
Improved PsA symptoms
58
Apremilast for PsA
59
Psoriasis
Psoriatic arthritis
60
Psoriasis treatment
Psoriatic arthritis treatment
RA treatment
61
Improved DLQI
Improved HAQ DI
Improved SF-36 PCS
Improved impact on productivity
Reduced disease activity
Reduced pain
62
Improved fatigue
Improved joint pain
63
Psoriasis treatment
64
PsA treatment
65
Improved psoriatic arthritis
Superior efficacy to placebo
66
Improved PsA treatment
67
Psoriatic arthritis treatment
68
New treatments
Psoriatic arthritis treatment
69
Clinical improvement
Reduced adverse effects
70
Biologic agents efficacy
71
PsA treatment
Secukinumab
72
Improved PsA treatment
73
PsA treatment
74
MTX and biologic therapy
PsA treatment
75
Drug treatment
PsA treatment
76
Improved PsA treatment
77
Psoriatic arthritis treatment
78
Biological therapies
Psoriatic arthritis treatment
79
PsA improvement
Radiographic progression reduction
80
Golimumab plus MTX
PsA treatment
81
Improved PsA treatment
82
PsA treatment
83
A (3) adenosine receptors agonist
ABT 122
Abatacept
IL-17 inhibitors
JAK inhibitors
PsA treatment
84
Disease modification
85
Improved PsA treatment
86
PsA treatment
88
Improved PsA treatment
89
PsA treatment
90
PsA treatment
TNFi switching
91
ACR20 response
PsA treatment
92
PsA treatment
93
Biologics plus MTX for psoriasis
94
PsA management recommendations
95
PsA treatment
96
PsA treatment
97
Psoriatic arthritis treatment
98
Apremilast efficacy
PsA treatment
99
IL-12/23 efficacy
IL-17A efficacy
100
Disease flare reduction
Safety profile
101
PsA treatment
102
PsA treatment
103
Nail psoriasis treatment
104
PsA diagnosis
PsA treatment
105
Psoriatic arthritis treatment
106
Psoriatic arthritis prevention
107
PsA treatment
108
Risk Keywords
Kidney dysfunction
4
Mild injection site reactions
6
Mild to moderate adverse events
9
Dactylitis
Psoriatic arthritis
10
Axial involvement in psoriatic arthritis
11
Psoriatic arthritis
12
Psoriatic arthritis
13
Psoriatic arthritis
14
Psoriatic arthritis
15
Joint disease progression
16
Psoriatic arthritis
17
Adverse events
18
Psoriatic arthritis
20
Side effects
21
AEs
27
Treatment-related adverse events
33
None mentioned
34
Tuberculosis risk
37
Infections
38
Insufficient data
Need for long-term studies
40
Cardiovascular comorbidities
Psoriasis
44
Psoriatic arthritis
47
Enthesitis
Psoriatic arthritis
51
Dactylitis
Psoriatic arthritis
52
Nail psoriasis
Psoriatic arthritis
54
Psoriatic arthritis
56
Diarrhea
Headache
Nausea
Upper respiratory tract infection
60
Psoriatic arthritis severity
Scalp psoriasis
63
Cancer
Frequent adverse events
Herpes zoster
Serious infections
66
Increased infection risk
67
Cost optimization
69
Biologic agents side effects
Immune response
71
Malignancy risk
74
No new safety signals
80
Adverse events
83
Cardiovascular events
Infections
Infusion reactions
Malignancies
Multiple sclerosis
88
serious adverse events
90
Poorer response (TNFi history)
91
Serious infections
92
No significant difference for PsA treatment
94
Lower efficacy in TNFi-experienced
100
Literature analysis of 108 papers
Positive Content
107
Neutral Content
1
Negative Content
0
Article Type
46
25
56
34
105
1.

Sulfasalazine therapy for psoriatic arthritis: a double blind, placebo controlled trial.

Author: GuptaA K, GroberJ S, HamiltonT A, EllisC N, SiegelM T, VoorheesJ J, McCuneW J

Improved psoriatic arthritis treatment

This study investigated the effectiveness of sulfasalazine for treating psoriatic arthritis (PsA), comparing it to placebo. Sulfasalazine is a medication that has been successful in treating rheumatoid arthritis, ankylosing spondylitis, and reactive arthritis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial.

Author: MeaseP J, GoffeB S, MetzJ, VanderStoepA, FinckB, BurgeD J

Improved psoriatic arthritis and psoriasis treatment

Etanercept, a medication that blocks tumor necrosis factor (TNF), has been effective for rheumatoid arthritis. Since TNF is also increased in joints and skin of people with psoriatic arthritis and psoriasis, these conditions may also benefit from etanercept treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis.

Author: SalvaraniC, MacchioniP, OlivieriI, MarchesoniA, CutoloM, FerraccioliG, CantiniF, SalaffiF, PadulaA, LovinoC, DovigoL, BordinG, DavoliC, PaseroG, AlberighiO D

Joint improvement
Pain reduction
Kidney dysfunction

Cyclosporine was more efficacious and well-tolerated than symptomatic therapy alone or sulfasalazine in the treatment of psoriatic arthritis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Cytokine blockers in psoriatic arthritis.

Author: MeaseP J

Improvement in psoriatic skin lesions
Significant improvement in PsA signs and symptoms

While the exact cause of psoriatic arthritis (PsA) and psoriasis is not fully understood, research suggests that inflammation-causing chemicals, like tumor necrosis factor (TNF), play a role. Common treatments for PsA, such as physical therapy, anti-inflammatory medications, corticosteroids, and methotrexate, have limited effectiveness. This study found that etanercept, a medication that blocks TNF, was well-tolerated and significantly improved PsA symptoms and skin lesions. Another TNF blocker, infliximab, has also been shown to be effective for PsA. These findings highlight the importance of TNF in PsA and offer hope for new treatment options.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Etanercept, a TNF antagonist for treatment for psoriatic arthritis and psoriasis.

Author: MeaseP J

Effective treatment of PsA
Improved psoriatic skin lesions
Well tolerated
Mild injection site reactions

Etanercept, a medication that blocks tumor necrosis factor (TNF), was approved to treat psoriatic arthritis (PsA) in 2002. It works by preventing TNF from interacting with cells, reducing inflammation. Two studies, involving a total of 265 patients, found etanercept to be more effective than placebo in treating PsA, with improvements in PsA symptoms and skin lesions. Side effects were minimal, with about a quarter of patients experiencing mild injection site reactions that resolved with continued treatment. Etanercept appears to be a safe and effective treatment for PsA, with a safety profile similar to its use in rheumatoid arthritis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Etanercept treatment of psoriatic arthritis: safety, efficacy, and effect on disease progression.

Author: MeasePhilip J, KivitzAlan J, BurchFrancis X, SiegelEvan L, CohenStanley B, OryPeter, SalonenDavid, RubensteinJoel, SharpJohn T, TsujiWayne

Improved psoriasis lesions
Inhibited radiographic progression
Reduced PsA symptoms

Etanercept is a drug that is used to treat psoriatic arthritis (PsA). This study found that etanercept significantly reduced the signs and symptoms of PsA and psoriasis. It also inhibited radiographic disease progression and was well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Continued inhibition of radiographic progression in patients with psoriatic arthritis following 2 years of treatment with etanercept.

Author: MeasePhilip J, KivitzAlan J, BurchFrancis X, SiegelEvan L, CohenStanley B, OryPeter, SalonenDavid, RubensteinJoel, SharpJohn T, DunnMeleana, TsujiWayne

Improved arthritis
Improved psoriasis
Inhibited radiographic progression
Well tolerated

Etanercept treatment, including inhibition of radiographic progression, was sustained in patients with psoriatic arthritis (PsA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Alefacept in combination with methotrexate for the treatment of psoriatic arthritis: results of a randomized, double-blind, placebo-controlled study.

Author: MeasePhilip J, GladmanDafna D, KeystoneEdward C,

PsA treatment
Mild to moderate adverse events

Alefacept in combination with MTX may be an effective and safe treatment for PsA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Therapies for dactylitis in psoriatic arthritis. A systematic review.

Author: HelliwellPhilip S

Improved dactylitis treatment
Dactylitis
Psoriatic arthritis

Dactylitis, or inflammation of the fingers and toes, is a key feature of psoriatic arthritis (PsA). This review found that dactylitis is linked to the severity of PsA and psoriasis. While traditional treatments include anti-inflammatory drugs and steroid injections, there is limited research on dactylitis treatment, and the need for better ways to measure its improvement. Infliximab is the only drug that has shown significant improvement in dactylitis in a clinical study.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Therapies for axial disease in psoriatic arthritis. A systematic review.

Author: NashPeter

Improved axial PsA treatment
Axial involvement in psoriatic arthritis

The prevalence of spine involvement in psoriatic arthritis (PsA) varies depending on the diagnostic criteria used. Because there is no specific research on treating spine involvement in PsA, experts recommend using the same treatment methods and outcome measures as for ankylosing spondylitis (AS), a related condition. This review examines the management of spine involvement in PsA and provides treatment recommendations based on research on AS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Systematic review of treatments for psoriatic arthritis: an evidence based approach and basis for treatment guidelines.

Author: KavanaughArthur F, RitchlinChristopher T,

Improved psoriatic arthritis treatment
Psoriatic arthritis

Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects joints and skin. It can involve various areas of the body, including joints, skin, nails, and tendons. The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) aims to develop treatment guidelines for PsA based on the best available scientific evidence. This paper outlines the methods used for a systematic review of PsA treatments, which will inform future treatment guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Etanercept and infliximab for the treatment of psoriatic arthritis: a systematic review and economic evaluation.

Author: WoolacottN, Bravo VergelY, HawkinsN, KainthA, KhadjesariZ, MissoK, LightK, AsseburgC, PalmerS, ClaxtonK, BruceI, SculpherM, RiemsmaR

Improved PsA treatment
Psoriatic arthritis

This study examines the effectiveness, safety, how well patients tolerate, and cost-effectiveness of etanercept and infliximab for treating active and worsening psoriatic arthritis (PsA) in people who haven't responded well to standard treatments, including disease-modifying antirheumatic drugs (DMARDs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

[The role of biological agents in the treatment of psoriatic arthritis, literature review].

Author: KoóEva, BrodszkyValentin, PéntekMárta, UjfalussyIlona, NagyMarianna Bettina, GulácsiLászló

Improved psoriatic arthritis treatment
Psoriatic arthritis

Understanding the role of TNF-alpha in psoriatic arthritis has led to new treatment options. TNF-alpha inhibitors (infliximab, etanercept, adalimumab), available in Hungary, offer potential for patients who haven't responded well to traditional treatments.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Hungarian

16.

Etanercept and infliximab for the treatment of psoriatic arthritis: a systematic review.

Author: WoolacottN F, KhadjesariZ C S, BruceI N, RiemsmaR P

Effective for PsA
Reduces joint pain
Joint disease progression

Etanercept and infliximab are both effective treatments for psoriatic arthritis (PsA) with benefits on both joint and psoriasis symptoms. Limited data suggest that both drugs may delay joint disease progression. Further long-term studies are needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Efalizumab for the treatment of psoriatic arthritis.

Author: PappKim A, CaroIvor, LeungHoi M, GarovoyMarvin, MeasePhilip J

Improved PsA treatment
Psoriatic arthritis

Psoriatic arthritis (PsA) is an inflammatory arthritis linked to psoriasis. Efalizumab, a medication that targets a type of immune cell called T cells, is approved for treating moderate to severe psoriasis. This study aims to investigate whether efalizumab is effective for treating PsA.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Safety and efficacy of adalimumab in treatment of patients with psoriatic arthritis who had failed disease modifying antirheumatic drug therapy.

Author: GenoveseMark C, MeasePhilip J, ThomsonGlen T D, KivitzAlan J, PerdokRenee J, WeinbergMark A, MedichJohn, SassoEric H,

PsA symptom reduction
Psoriasis improvement
Adverse events

Adalimumab was well tolerated and significantly reduced the signs, symptoms, and disability of psoriatic arthritis (PsA) in patients who had an inadequate response to disease modifying antirheumatic drugs (DMARD). Adalimumab also improved psoriasis in these patients.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Infliximab inhibits progression of radiographic damage in patients with active psoriatic arthritis through one year of treatment: Results from the induction and maintenance psoriatic arthritis clinical trial 2.

Author: van der HeijdeD, KavanaughA, GladmanD D, AntoniC, KruegerG G, GuzzoC, ZhouB, DooleyL T, de VlamK, GeusensP, BirbaraC, HalterD, BeutlerA

Psoriatic arthritis treatment

Infliximab significantly inhibits radiographic progression in patients with PsA as early as 6 months after starting treatment, and the beneficial effect continues through 1 year of infliximab therapy.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

A systematic review and meta-analysis of efficacy and toxicity of disease modifying anti-rheumatic drugs and biological agents for psoriatic arthritis.

Author: RavindranV, ScottD L, ChoyE H

Improved PsA treatment
Psoriatic arthritis

This study compares the effectiveness and side effects of expensive medications like TNF inhibitors (which have been studied in large controlled trials) and less expensive disease-modifying anti-rheumatic drugs (DMARDs) for treating psoriatic arthritis (PsA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

[Results of leflunomide treatment of psoriatic arthritis].

Author: PchelintsevaA O, KorotaevaT V, GodzenkoA A, KorsakovaIu L, StanislavM L, DenisovL N

Improved function
Improved quality of life
Reduced joint pain
Side effects

This study found that leflunomide (LF) is highly effective in the treatment of polyarticular psoriatic arthritis (PsA) and has satisfactory tolerance.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

22.

A prospective, randomised, placebo-controlled study to identify biomarkers associated with active treatment in psoriatic arthritis: effects of adalimumab treatment on synovial tissue.

Author: van KuijkA W R, GerlagD M, VosK, WolbinkG, de GrootM, de RieM A, ZwindermanA H, DijkmansB A C, TakP P

Reduced MMP13 expression
Reduced T cell infiltration

Morphine treatment resulted in a significant decrease in intensity of postamputation pain compared with placebo and mexiletine, but was associated with a higher rate of side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Adalimumab for long-term treatment of psoriatic arthritis: 2-year data from the Adalimumab Effectiveness in Psoriatic Arthritis Trial (ADEPT).

Author: MeaseP J, OryP, SharpJ T, RitchlinC T, Van den BoschF, WellborneF, BirbaraC, ThomsonG T D, PerdokR J, MedichJ, WongR L, GladmanD D

Psoriatic arthritis treatment

The clinical and radiographic efficacy of adalimumab demonstrated during short-term treatment was sustained during long-term treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Alefacept with methotrexate for treatment of psoriatic arthritis: open-label extension of a randomized, double-blind, placebo-controlled study.

Author: MeasePhilip J, ReichKristian,

Improved psoriasis and psoriatic arthritis

An additional course of alefacept in combination with methotrexate (MTX) provided further benefit for both psoriasis and psoriatic arthritis (PsA) without additional toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial.

Author: GottliebAlice, MenterAlan, MendelsohnAlan, ShenYaung-Kaung, LiShu, GuzzoCynthia, FretzinScott, KunynetzRod, KavanaughArthur

Psoriatic arthritis treatment

Some people with psoriatic arthritis don't respond to standard treatments, so new options are needed. Research suggests that interleukins 12 and 23 might be involved in the symptoms and joint damage of psoriatic arthritis. Ustekinumab is a medication that blocks these substances. This phase II study examines the effectiveness and safety of ustekinumab for psoriatic arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Treatment strategies for early psoriatic arthritis.

Author: OlivieriIgnazio, D'AngeloSalvatore, PalazziCarlo, PadulaAngela

Early PsA diagnosis

Early diagnosis of psoriatic arthritis (PsA) was not a major focus until recently, as there were no medications that could significantly change the course of the disease. However, the development of drugs that block TNF-alpha has made early diagnosis of PsA much more important.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Comparison of effectiveness and safety of infliximab, etanercept, and adalimumab in psoriatic arthritis patients who experienced an inadequate response to previous disease-modifying antirheumatic drugs.

Author: AttenoMariangela, PelusoRosario, CostaLuisa, PadulaStefania, IervolinoSalvatore, CasoFrancesco, SanduzziAlessandro, LubranoEnnio, Del PuenteAntonio, ScarpaRaffaele

PsA treatment
AEs

This study compared the effectiveness and safety of three medications for psoriatic arthritis (PsA) in people who had not responded well to previous treatments: Infliximab (INF), Etanercept (ETN), and Adalimumab (ADA). All three medications significantly improved PsA symptoms, but each had unique benefits. ETN showed the greatest improvement in joint tenderness and disability, while INF and ADA showed the most improvement in skin lesions. Side effects were reported in 15% of patients, with only two considered drug-related (pneumonitis and low platelet count) in those taking INF. This study suggests that these medications effectively treat PsA, but understanding their individual strengths may help optimize treatment choices.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

[Psoriatic arthritis and etanercept].

Author: PedrazJ, DaudénE

PA treatment

Psoriatic arthritis (PA) is a chronic inflammatory condition that usually develops after skin symptoms. Early diagnosis and treatment are crucial to prevent severe joint damage. Traditional treatments include NSAIDs, DMARDs like methotrexate, sulfasalazine, or gold, and leflunomide. New treatments that target specific inflammation-causing substances (biological treatments) have been developed, including anti-TNF drugs like etanercept, infliximab, and adalimumab. This review examines the main studies on etanercept for treating PA.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

29.

Cost-effectiveness of infliximab for the treatment of active and progressive psoriatic arthritis.

Author: CumminsEwen, AsseburgChristian, PunekarYogesh Suresh, ShoreEmily, MorrisJames, BriggsAndrew, FenwickElisabeth

Cost-effective treatment

Infliximab was a cost-effective treatment option for active and progressive psoriatic arthritis. In a decision analytic model, infliximab was associated with a significant reduction in Health Assessment Questionnaire score and a cost-effectiveness ratio well within the National Institute for Health and Clinical Excellence threshold.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis: a systematic review and economic evaluation.

Author: RodgersM, EpsteinD, BojkeL, YangH, CraigD, FonsecaT, MyersL, BruceI, ChalmersR, BujkiewiczS, LaiM, CooperN, AbramsK, SpiegelhalterD, SuttonA, SculpherM, WoolacottN

Joint Disease Reduction
PsA Treatment
Skin Disease Reduction

Etanercept, infliximab, and adalimumab were effective in treating psoriatic arthritis (PsA) compared to placebo, with improvements in joint symptoms, functional status, and skin. Etanercept was the most cost-effective option for patients with mild-to-moderate psoriasis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Indirect comparison of etanercept, infliximab, and adalimumab for psoriatic arthritis: mixed treatment comparison using placebo as common comparator.

Author: MiglioreAlberto, BizziEmanuele, BroccoliSerena, LaganàBruno

Improved PsA treatment

Psoriatic arthritis (PsA) is a chronic condition affecting joints and skin that can cause significant disability. While TNF-blocking drugs are used for PsA, there haven't been direct comparisons of the most common ones: adalimumab, etanercept, and infliximab. This analysis, using data from previous studies, suggests that etanercept may be the most effective of these three drugs in treating PsA that doesn't respond to standard medications. This information could help doctors make better treatment decisions for PsA patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

A systematic literature review of drug therapies for the treatment of psoriatic arthritis: current evidence and meta-analysis informing the EULAR recommendations for the management of psoriatic arthritis.

Author: AshZoe, Gaujoux-VialaCécile, GossecLaure, HensorElizabeth M A, FitzGeraldOliver, WinthropKevin, van der HeijdeDésirée, EmeryPaul, SmolenJosef S, Marzo-OrtegaHelena

Treatment of psoriatic arthritis

This review examines the effectiveness and safety of various treatments for psoriatic arthritis (PsA), including non-steroidal anti-inflammatory drugs (NSAIDs), synthetic medications, and biologics. The findings will be used to develop treatment recommendations by the European League Against Rheumatism (EULAR).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Infliximab plus methotrexate is superior to methotrexate alone in the treatment of psoriatic arthritis in methotrexate-naive patients: the RESPOND study.

Author: BaranauskaiteAsta, RaffayováHelena, KungurovN V, KubanovaAnna, VenalisAlgirdas, HelmleLaszlo, SrinivasanShankar, NasonovEvgeny, VastesaegerNathan,

Improved PASI
Improved PsA
Treatment-related adverse events

Infliximab plus methotrexate was more effective than methotrexate alone in treating active psoriatic arthritis (PsA) in methotrexate-naive patients. Infliximab plus methotrexate led to significantly greater ACR20 response rates and PASI75 improvement compared to methotrexate alone, and was generally well tolerated.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Self-reported health outcomes in patients with psoriasis and psoriatic arthritis randomized to two etanercept regimens.

Author: GniadeckiR, RobertsonD, MoltaC T, FreundlichB, PedersenR, LiW, BoggsR, ZbrozekA S

Improved QoL
Improved skin symptoms
None mentioned

Both etanercept regimens led to sustained PRO improvements, starting as early as Week 3.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Treatment of psoriatic arthritis with tumor necrosis factor inhibitors: longer-term outcomes including enthesitis and dactylitis with golimumab treatment in the Longterm Extension of a Randomized, Placebo-controlled Study (GO-REVEAL).

Author: KavanaughArthur, MeasePhilip

Improved PsA

Treatment of PsA patients with the TNF inhibitor golimumab was effective in improving enthesitis and dactylitis, and efficacy was maintained over longer-term followup.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Systematic literature review on economic implications and pharmacoeconomic issues of psoriatic arthritis.

Author: CortesiPaolo A, ScaloneLuciana, D'AngiolellaLucia, BelisariAndrea, FuscoFrancesco, OlivieriIgnazio, MantovaniLorenzo G

Treatment of PsA

New medications that block TNF-α have significantly improved treatment for psoriatic arthritis (PsA), a condition that affects both joints and skin. While many patients respond well to older medications like methotrexate, those who don't benefit fully from these medications can find improvement with TNF-α blockers. These medications reduce inflammation, minimize joint damage, and improve quality of life. While TNF-α blockers are expensive, studies have shown that they can be cost-effective in managing both the joint and skin aspects of psoriatic disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Clinical efficacy, radiographic and safety findings through 2 years of golimumab treatment in patients with active psoriatic arthritis: results from a long-term extension of the randomised, placebo-controlled GO-REVEAL study.

Author: KavanaughArthur, McInnesIain B, MeasePhilip J, KruegerGerald G, GladmanDafna D, van der HeijdeDésirée, MudivarthySurekha, XuWeichun, MackMichael, XuZhenhua, BeutlerAnna

Psoriatic arthritis treatment
Tuberculosis risk

Golimumab 50 and 100 mg for up to 2 years yielded sustained clinical and radiographic efficacy in patients with active psoriatic arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Influence of psoriatic arthritis on the efficacy of adalimumab and on the treatment response of other markers of psoriasis burden: subanalysis of the BELIEVE study.

Author: PaulCarle, van de KerkhofPeter, PuigLluis, UnnebrinkKristina, GoldblumOrin, ThaçiDiamant

Nail psoriasis treatment
Psoriasis treatment
Infections

Adalimumab treatment resulted in significant improvements in skin, nails, quality of life, pain, and pruritus for patients with moderate to severe psoriasis, regardless of their baseline psoriatic arthritis status.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

The TICOPA protocol (TIght COntrol of Psoriatic Arthritis): a randomised controlled trial to compare intensive management versus standard care in early psoriatic arthritis.

Author: CoatesLaura C, Navarro-CoyNuria, BrownSarah R, BrownSarah, McParlandLucy, CollierHoward, SkinnerEmma, LawJennifer, MoverleyAnna, PavittSue, HulmeClaire, EmeryPaul, ConaghanPhilip G, HelliwellPhilip S

Improved clinical outcome

Psoriatic arthritis (PsA), which affects about 10-15% of people with psoriasis, is a serious condition. While new treatments are available, they are expensive and there is a need to understand the best approach for treating PsA. This study aims to compare a "tight control" approach, using specific medications and goals, to standard care in people with early PsA, to see if it improves outcomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Effects of biologic agents and other disease-modifying antirheumatic drugs on cardiovascular outcomes in psoriasis and psoriatic arthritis: a systematic review.

Author: ArmstrongApril W, BrezinskiElizabeth A, FollansbeeMatthew R, ArmstrongEhrin J

Potential for reduced cardiovascular events
Insufficient data
Need for long-term studies

Epidemiologic data is insufficient to reach definitive conclusions regarding the effects of biologics and other DMARDs on cardiovascular outcomes in psoriasis and psoriatic arthritis patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Utility of the PASE questionnaire, psoriatic arthritis (PsA) prevalence and PsA improvement with anti-TNF therapy: results from the PRISTINE trial.

Author: HusniM Elaine, QureshiAbrar A, KoenigAndrew S, PedersenRonald, RobertsonDeborah

PsA screening
Treatment response measurement

A study of 273 participants with moderate to severe psoriasis found that the Psoriatic Arthritis Screening and Evaluation (PASE) was useful for screening for psoriatic arthritis (PsA) both before and after anti-TNF treatment. The PASE score correlated with subject global assessment of joint pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial.

Author: McInnesIain B, KavanaughArthur, GottliebAlice B, PuigLluís, RahmanProton, RitchlinChristopher, BrodmerkelCarrie, LiShu, WangYuhua, MendelsohnAlan M, DoyleMittie K,

PsA treatment

This study investigates the safety and effectiveness of ustekinumab, a medication targeting a specific protein involved in inflammation, in treating active psoriatic arthritis, a condition affecting joints, tendons, and ligaments in people with psoriasis.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Safety of anti-tumor necrosis factor agents in psoriatic arthritis - an update.

Author: PalazziCarlo, D'AngeloSalvatore, LeccesePietro, PadulaAngela, OlivieriIgnazio

PsA treatment

Medications that block tumor necrosis factor (TNF) have revolutionized treatment for rheumatoid arthritis and spondyloarthritides (SpAs). For psoriatic arthritis (PsA), these medications are much more effective than conventional treatments in addressing all aspects of the disease, including spine, joints, tendons, fingers, and skin lesions. Understanding their safety is crucial for doctors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Cardiometabolic profile, clinical features, quality of life and treatment outcomes in patients with moderate-to-severe psoriasis and psoriatic arthritis.

Author: PuigLuis, StrohalRobert, HusniM Elaine, TsaiTsen-Fang, NoppakunNopadon, SzumskiAnnette, YangShiyi, RobertsonDeborah, BoggsRobert, KoenigAndrew S

Etanercept treatment
Improved quality of life
Cardiovascular comorbidities
Psoriasis

This study found that people with moderate to severe psoriasis, with or without psoriatic arthritis (PsA), had a high prevalence of cardiovascular risk factors like high blood pressure and diabetes. Etanercept treatment significantly improved psoriasis symptoms and quality of life in both groups, with those who also had PsA showing greater improvements in quality of life. The study highlights the importance of monitoring cardiovascular health in people with psoriasis and the benefits of etanercept for improving skin symptoms and quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Systematic review, network meta-analysis and economic evaluation of biological therapy for the management of active psoriatic arthritis.

Author: CawsonMatthew Richard, MitchellStephen Andrew, KnightChris, WildeyHenry, SpurdenDean, BirdAlex, OrmeMichelle Elaine

PsA treatment

This economic evaluation found that all four licensed TNF-α inhibitors were significantly more effective than placebo in achieving PsARC response in patients with active PsA. Etanercept was found to be the most cost-effective treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence-based recommendations and expert opinion.

Author: SevrainM, RichardM-A, BarnetcheT, RouzaudM, VillaniA P, PaulC, Beylot-BarryM, JullienD, AractingiS, AubinF, JolyP, Le MaitreM, CantagrelA, OrtonneJ-P, MiseryL

Arotinoid ethylesther efficacy
Excimer 308 nm efficacy
PPPP symptom relief
PUVA efficacy

A systematic literature review evaluated evidence-based recommendations for palmoplantar pustular psoriasis (PPPP) treatment. The review found that phototherapy, ciclosporin, and topical corticosteroids may be helpful in controlling PPPP. However, further research is needed to define treatment strategies for PPPP.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Current treatment of psoriatic arthritis: update based on a systematic literature review to establish French Society for Rheumatology (SFR) recommendations for managing spondyloarthritis.

Author: PaccouJulien, WendlingDaniel

Psoriatic arthritis

This study provides updated recommendations for managing psoriatic arthritis (PsA) based on a literature review and expert opinion. The recommendations build upon previous guidelines from the French Society for Rheumatology and the European League Against Rheumatism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis.

Author: AdemowoOpeyemi S, HernandezBelinda, CollinsEmily, RooneyCathy, FearonUrsula, van KuijkArno W, TakPaul-P, GerlagDanielle M, FitzGeraldOliver, PenningtonStephen R

PsA treatment

While biological medications can be effective for psoriatic arthritis (PsA), they are expensive and can cause side effects. This study aims to identify specific proteins in the blood that could predict which patients with PsA will respond well to biological treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Systematic review of treatments for psoriatic arthritis: 2014 update for the GRAPPA.

Author: CoatesLaura C, KavanaughArthur, RitchlinChristopher T,

PsA treatment

Psoriatic arthritis (PsA) is a chronic inflammatory condition affecting both joints and skin. The disease can manifest in various ways, including joint pain, skin lesions, and nail problems, impacting function and quality of life. This review updates treatment recommendations for PsA, providing guidance on managing the different aspects of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Drug therapies for peripheral joint disease in psoriatic arthritis: a systematic review.

Author: Acosta FelquerMaria Laura, CoatesLaura C, SorianoEnrique R, RanzaRoberto, EspinozaLuis R, HelliwellPhilip S, FitzGeraldOliver, McHughNeil, RoussouEuthalia, MeasePhilip J

PsA treatment

This review updates previous guidelines on treating psoriatic arthritis (PsA), focusing on the joint involvement in the limbs. It summarizes the evidence for different treatments, management strategies, and therapies used for PsA, to inform the development of new guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Systematic review of treatment effectiveness and outcome measures for enthesitis in psoriatic arthritis.

Author: OrbaiAna-Maria, WeitzJoshua, SiegelEvan L, SiebertStefan, SavageLaura J, AydinSibel Z, LuimeJolanda J, ElkayamOri, NeerinckxBarbara, UrbancekSlavo, de VlamKurt, RitchlinChristopher T,

Enthesitis
Psoriatic arthritis

This review examines the use of clinical outcome measures for enthesitis in psoriatic arthritis (PsA). Enthesitis, an important feature of PsA, is assessed using various methods, but only one measure is specifically validated for this condition. The review suggests the need for further research on the use of ultrasound and magnetic resonance imaging in assessing enthesitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Comprehensive treatment of dactylitis in psoriatic arthritis.

Author: RoseShawn, TolozaSergio, Bautista-MolanoWilson, HelliwellPhilip S,

Certolizumab
Infliximab
Ustekinumab
Dactylitis
Psoriatic arthritis

Dactylitis, a painful swelling of fingers and toes, is a common symptom of psoriatic arthritis (PsA) and other related conditions. While traditional medications are used, research suggests that newer biologic drugs like ustekinumab, certolizumab, and infliximab are most effective for dactylitis. However, more research is needed to confirm these findings and develop better ways to assess the effectiveness of treatments for dactylitis in PsA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Safety and efficacy of therapies for skin symptoms of psoriasis in patients with psoriatic arthritis: a systematic review.

Author: BoehnckeWolf-Henning, Alvarez MartinezDavid, SolomonJames A, GottliebAlice B

PsA treatment

While there are guidelines for treating psoriasis, a significant population involves people with both joint and skin symptoms (psoriatic arthritis, PsA). Although treating the skin and joints separately is common, using the same medication for both can be possible. This review examines the effectiveness of various medications on skin symptoms in people with PsA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Treatments for nail psoriasis: a systematic review by the GRAPPA Nail Psoriasis Work Group.

Author: ArmstrongApril W, TuongWilliam, LoveThorvardur J, CarneiroSueli, GrynszpanRachel, LeeSteve S, KavanaughArthur

Nail psoriasis
Psoriatic arthritis

This study reviews research on nail psoriasis, a condition that affects the fingernails and toenails and can cause pain, difficulty with daily activities, and cosmetic concerns. The study highlights the need to address nail psoriasis in managing overall psoriasis and psoriatic arthritis, and aims to inform the development of updated treatment recommendations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Early treatment of psoriatic arthritis is associated with improved patient-reported outcomes: findings from the etanercept PRESTA trial.

Author: KirkhamBruce, de VlamKurt, LiWenzhi, BoggsRobert, MallbrisLotus, NabHenk W, TaralloMiriam

Improved QoL
Improved arthritis scores

Etanercept (ETN) was effective in treating psoriatic arthritis (PsA) regardless of disease duration. However, patients with PsA for less than two years experienced greater improvements in arthritis scores and several patient-reported outcome (PRO) measures.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

Effects of mud-bath therapy in psoriatic arthritis patients treated with TNF inhibitors. Clinical evaluation and assessment of synovial inflammation by contrast-enhanced ultrasound (CEUS).

Author: CozziFranco, RaffeinerBernd, BeltrameValeria, CiprianLuca, CoranAlessandro, BotsiosConstantin, PerissinottoEgle, GrisanEnrico, RamondaRoberta, OlivieroFrancesca, StramareRoberto, PunziLeonardo

Mud-bath therapy
Psoriatic arthritis

This study evaluates the effects of mud-bath therapy in patients with psoriatic arthritis (PsA) already receiving TNF inhibitors. While TNF inhibitors are effective, many patients experience residual inflammation. The research aims to assess the impact of mud-bath therapy on clinical symptoms, synovial inflammation, and overall well-being.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

57.

Indirect comparisons of the efficacy of biological agents in patients with psoriatic arthritis with an inadequate response to traditional disease-modifying anti-rheumatic drugs or to non-steroidal anti-inflammatory drugs: A meta-analysis.

Author: UngprasertPatompong, ThongprayoonCharat, DavisJohn M

PsA treatment

While new biologic medications have proven effective for psoriatic arthritis (PsA) in clinical trials, there is limited research comparing these treatments. This meta-analysis aims to compare the effectiveness of different biologic medications in patients who haven't responded to traditional medications or who can't tolerate them.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Pharmacological treatment of psoriatic arthritis: a systematic literature review for the 2015 update of the EULAR recommendations for the management of psoriatic arthritis.

Author: RamiroSofia, SmolenJosef S, LandewéRobert, van der HeijdeDésirée, DougadosMaxime, EmeryPaul, de WitMaarten, CutoloMaurizio, OliverSusan, GossecLaure

Improved PsA symptoms

Ustekinumab, secukinumab, and apremilast are new drugs that have been shown to be effective in treating psoriatic arthritis (PsA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

An indirect comparison and cost per responder analysis of adalimumab, methotrexate and apremilast in the treatment of methotrexate-naïve patients with psoriatic arthritis.

Author: BettsKeith A, GriffithJenny, FriedmanAlan, ZhouZheng-Yi, SignorovitchJames E, GanguliArijit

Apremilast for PsA

This study compares the response rates and incremental costs associated with different treatments for active psoriatic arthritis (PsA): methotrexate, apremilast, and biologics. The study aims to provide information for making informed treatment decisions based on effectiveness and cost.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3).

Author: EdwardsChristopher J, BlancoFrancisco J, CrowleyJeffrey, BirbaraCharles A, JaworskiJanusz, AelionJacob, StevensRandall M, VesseyAdele, ZhanXiaojiang, BirdPaul

Psoriasis
Psoriatic arthritis
Diarrhea
Headache
Nausea
Upper respiratory tract infection

Apremilast demonstrated clinically meaningful improvements in psoriatic arthritis and psoriasis at week 16; sustained improvements were seen with continued treatment through 52 weeks. Apremilast was generally well tolerated and demonstrated an acceptable safety profile.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

61.

Psoriasis, psoriatic arthritis, and rheumatoid arthritis: Is all inflammation the same?

Author: CoatesLaura C, FitzGeraldOliver, HelliwellPhilip S, PaulCarle

Psoriasis treatment
Psoriatic arthritis treatment
RA treatment

This review examines the causes, associated conditions, and treatment options for psoriasis, psoriatic arthritis, and rheumatoid arthritis. The goal is to better understand the similarities and differences in how these diseases are managed and to identify new targets for personalized treatments that improve outcomes and reduce side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

Ustekinumab Treatment and Improvement of Physical Function and Health-Related Quality of Life in Patients With Psoriatic Arthritis.

Author: RahmanProton, PuigLluis, GottliebAlice B, KavanaughArthur, McInnesIain B, RitchlinChristopher, LiShu, WangYuhua, SongMichael, MendelsohnAlan, HanChenglong,

Improved DLQI
Improved HAQ DI
Improved SF-36 PCS
Improved impact on productivity
Reduced disease activity
Reduced pain

Ustekinumab significantly improved patient-reported outcomes in patients with active psoriatic arthritis (PsA) regardless of prior methotrexate (MTX) or anti-tumor necrosis factor (TNF) use. Ustekinumab was associated with clinically meaningful improvements in HAQ DI, DLQI, and SF-36 scores.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

63.

Limited association between scalp psoriasis and psoriatic arthritis severity and treatment response.

Author: de VlamKurt, MallbrisLotus, SzumskiAnnette, JonesHeather

Improved fatigue
Improved joint pain
Psoriatic arthritis severity
Scalp psoriasis

Scalp psoriasis was not clearly associated with psoriatic arthritis severity, and it did not affect treatment response to etanercept. Patients without scalp PsO exhibited greater improvements in objective joint outcomes, whereas patients with scalp PsO experienced better outcomes in patient-reported outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

64.

Secukinumab demonstrates greater sustained improvements in daily activities and personal relationships than ustekinumab in patients with moderate-to-severe plaque psoriasis: 52-week results from the CLEAR study.

Author: BlauveltA, ReichK, MehlisS, VanaclochaF, SofenH, AbramovitsW, ZhaoY, GilloteauI, DavenportE, WilliamsN, GuanaA, TyringS

Psoriasis treatment

Psoriasis can negatively affect a person's life, impacting clothing choices and sexual function. Secukinumab, a medication that targets a specific immune protein, has shown good results in treating moderate-to-severe psoriasis and psoriatic arthritis, with rapid improvement and lasting effects.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

65.

The GOLMePsA study protocol: an investigator-initiated, double-blind, parallel-group, randomised, controlled trial of GOLimumab and methotrexate versus methotrexate in early diagnosed psoriatic arthritis using clinical and whole body MRI outcomes.

Author: De MarcoGabriele, HelliwellPhilip, McGonagleDennis, EmeryPaul, CoatesLaura C, HensorElizabeth M A, Marzo-OrtegaHelena

PsA treatment

Psoriatic arthritis (PsA) is a chronic condition that causes joint inflammation and affects quality of life. Early treatment is important for long-term outcomes. This study compares a new treatment approach for people newly diagnosed with PsA (golimumab, methotrexate, and steroids) to standard treatment (methotrexate and steroids) to determine which is more effective.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

66.

Tofacitinib or Adalimumab versus Placebo for Psoriatic Arthritis.

Author: MeasePhilip, HallStephen, FitzGeraldOliver, van der HeijdeDésirée, MerolaJoseph F, Avila-ZapataFrancisco, CieślakDorota, GrahamDaniela, WangCunshan, MenonSujatha, HendrikxThijs, KanikKeith S

Improved psoriatic arthritis
Superior efficacy to placebo
Cancer
Frequent adverse events
Herpes zoster
Serious infections

Tofacitinib was more effective than placebo in patients with psoriatic arthritis who had previously had an inadequate response to conventional synthetic DMARDs. The ACR20 response rates at month 3 were 50% in the 5-mg tofacitinib group and 61% in the 10-mg tofacitinib group, as compared with 33% in the placebo group. Adverse events were more frequent with tofacitinib than with placebo.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Th17 Inhibitors in Active Psoriatic Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Author: NaikGirish S, MingWai K, MagodoroItai M, AkinwunmiBabatunde, DarSara, PoulsenHenrik E, KristensenLars E, EllervikChristina

Improved PsA treatment
Increased infection risk

This study compared the effectiveness of Th17 pathway inhibitors to placebo or active control in treating active psoriatic arthritis (PsA), evaluating their potential to replace TNF-α antagonists as first-line biologic agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Is secukinumab effective for psoriatic arthritis with insufficient response to initial treatment?

Author: Venegas-IribarrenSoledad, Andino-NavarreteRomina

Psoriatic arthritis treatment

Psoriatic arthritis is a type of arthritis with no known cause. Biological therapies, especially for severe cases, have become important for treatment. While secukinumab is a potential biological treatment option, its effectiveness and safety, especially given its high cost, are not completely understood.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Spanish

69.

Cost and Cost Effectiveness of Treatments for Psoriatic Arthritis: A Systematic Literature Review.

Author: D'AngiolellaLucia Sara, CortesiPaolo Angelo, LafranconiAlessandra, MicaleMariangela, ManganoSveva, CesanaGiancarlo, MantovaniLorenzo Giovanni

New treatments
Psoriatic arthritis treatment
Cost optimization

Psoriatic arthritis is a chronic inflammatory condition affecting joints and skin. It can lead to joint damage and is associated with other health problems. New treatments have emerged in recent years, but it's important to compare their costs and benefits to make the best use of available resources.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Is ustekinumab effective for psoriatic arthritis with insufficient response to initial treatment?

Author: Venegas-IribarrenSoledad, Andino-NavarreteRomina

Clinical improvement
Reduced adverse effects

Ustekinumab was found to lead to clinical improvement in psoriatic arthritis and is probably not associated with severe adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Spanish

71.

The comparative immunogenicity of biologic therapy and its clinical relevance in psoriatic arthritis: a systematic review of the literature.

Author: BalsaAlejandro, LulaSadiq, MarshallLisa, SzczypaPiotr, AikmanLaraine

Biologic agents efficacy
Biologic agents side effects
Immune response

Immune responses to biologic therapeutic agents in patients with psoriatic arthritis (PsA) are similar to those observed in other rheumatic diseases. Therapeutic drug monitoring may be helpful in assessing the immune response and optimizing treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Cost Effectiveness of Secukinumab for the Treatment of Active Psoriatic Arthritis in the UK.

Author: BuchananVanessa, SullivanWill, GrahamChris, MilesLaStella, JuglSteffen Marc, GundaPraveen, HallidayAnna, KirkhamBruce

PsA treatment
Secukinumab

This study examines the cost-effectiveness of using secukinumab, a medication that targets a specific immune protein, to treat adults in the UK with psoriatic arthritis (PsA) who haven't been treated with tumor necrosis factor inhibitors (TNFi) and don't have severe psoriasis. The study focuses on people who haven't responded well to standard medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

Efficacy and safety of guselkumab in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 study.

Author: DeodharAtul, GottliebAlice B, BoehnckeWolf-Henning, DongBin, WangYuhua, ZhuangYanli, BarchukWilliam, XuXie L, HsiaElizabeth C,

Improved PsA treatment

This study assessed the efficacy and safety of guselkumab, a human monoclonal antibody targeting interleukin 23, for treating active psoriatic arthritis, considering its approval for moderate-to-severe psoriasis.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

74.

Malignancy development risk in psoriatic arthritis patients undergoing treatment: A systematic review and meta-analysis.

Author: LuoXuan, DengChuiwen, FeiYunyun, ZhangWen, LiYongzhe, ZhangXuan, ZhaoYan, ZengXiaofeng, ZhangFengchun

PsA treatment
Malignancy risk

Psoriatic arthritis is a chronic inflammatory condition that affects people with psoriasis. There is debate about whether treatment for psoriatic arthritis increases the risk of developing cancer. This review examines the relationship between cancer risk and treatment for psoriatic arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

[Value of combining biologics with methotrexate for treatment of psoriatic arthritis-questions remain].

Author: DauthS, KöhmM, RossmanithT, HerrmannE, LehnA, BurkhardtH, BehrensF

MTX and biologic therapy
PsA treatment

Methotrexate (MTX) can improve the effectiveness of biologic medications for rheumatoid arthritis. However, it's unclear if the same is true for psoriatic arthritis (PsA), as research is limited. We know that people with PsA who don't respond well to MTX or other pain relievers alone can benefit from biologic treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

76.

Time until onset of action when treating psoriatic arthritis: meta-analysis and novel approach of generating confidence intervals.

Author: PhamPhuong Anh, DresslerCorinna, EisertLisa, NastAlexander, WernerRicardo Niklas

Drug treatment
PsA treatment

This study looked at how quickly different drugs for psoriatic arthritis (PsA) started showing effects. They found that infliximab, ixekizumab, and tofacitinib were the fastest to show improvement in joint symptoms within 2 weeks. Adalimumab and secukinumab showed improvement within 4 weeks. Apremilast and ustekinumab took longer. For skin symptoms, ixekizumab was faster than adalimumab in improving skin appearance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Tofacitinib or adalimumab versus placebo: patient-reported outcomes from OPAL Broaden-a phase III study of active psoriatic arthritis in patients with an inadequate response to conventional synthetic disease-modifying antirheumatic drugs.

Author: StrandVibeke, de VlamKurt, Covarrubias-CobosJose A, MeasePhilip J, GladmanDafna D, GrahamDaniela, WangCunshan, CappelleriJoseph C, HendrikxThijs, HsuMing-Ann

Improved PsA treatment

Tofacitinib, an oral Janus kinase inhibitor, shows promise as a treatment option for psoriatic arthritis (PsA) patients refractory to conventional synthetic disease-modifying antirheumatic drugs (csDMARD-IR) and who are tumor necrosis factor inhibitor-naïve.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

78.

Efficacy and safety of systemic treatments in psoriatic arthritis: a systematic review, meta-analysis and GRADE evaluation.

Author: DresslerC, EisertL, PhamP A, NastA

Psoriatic arthritis treatment

Psoriatic arthritis affects people with psoriasis and causes joint inflammation. This review examined the effectiveness of various treatments for psoriatic arthritis. Many medications were found to be effective for reducing joint inflammation and improving function. Newer treatments, including anti-TNF antibodies, ustekinumab, and anti-IL-17 antibodies, appear to be effective as well. More research is needed to compare the effectiveness of these new treatments to existing options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Evolution of psoriatic arthritis study patient population characteristics in the era of biological treatments.

Author: VandendorpeAnn-Sophie, de VlamKurt, LoriesRik

Biological therapies
Psoriatic arthritis treatment

Psoriatic arthritis is a chronic inflammatory condition affecting the joints. Biological therapies have dramatically improved treatment for this disease. This study examines whether the types of patients participating in clinical trials for psoriatic arthritis have changed since the introduction of biological treatments, reflecting potential shifts in how doctors treat the condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Etanercept and Methotrexate as Monotherapy or in Combination for Psoriatic Arthritis: Primary Results From a Randomized, Controlled Phase III Trial.

Author: MeasePhilip J, GladmanDafna D, CollierDavid H, RitchlinChristopher T, HelliwellPhilip S, LiuLyrica, KricorianGregory, ChungJames B

PsA improvement
Radiographic progression reduction
No new safety signals

Etanercept monotherapy and combination therapy with etanercept and methotrexate showed greater efficacy than methotrexate monotherapy in patients with psoriatic arthritis (PsA). Combining methotrexate and etanercept did not improve the efficacy of etanercept.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

81.

Achieving remission in psoriatic arthritis by early initiation of TNF inhibition: a double-blind, randomised, placebo-controlled trial of golimumab plus methotrexate versus placebo plus methotrexate.

Author: van MensLeonieke J J, de JongHenriëtte M, FluriInka, NurmohamedMichael T, van de SandeMarleen G H, KokMarc, van KuijkArno W R, BaetenDominique

Golimumab plus MTX
PsA treatment

Early treatment is important for achieving remission in rheumatoid arthritis, but it's unclear if this is also true for psoriatic arthritis (PsA). This study investigates whether combining golimumab with methotrexate (MTX) as the initial treatment is more effective than using methotrexate alone for achieving remission in PsA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

82.

Treatment of Dactylitis and Enthesitis in Psoriatic Arthritis with Biologic Agents: A Systematic Review and Metaanalysis.

Author: MouradAhmed, GniadeckiRobert

Improved PsA treatment

Biologic agents, including inhibitors of tumor necrosis factor-α (TNF-α), interleukin (IL)-12/23, and IL-17, show efficacy in treating psoriatic arthritis, particularly in reducing dactylitis and enthesitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Efficacy and safety of leflunomide in psoriatic arthritis treatment: A single-arm meta-analysis.

Author: DaiQiaoding, XuLiping, YuXiali

PsA treatment
Adverse events

Leflunomide is an effective and well-tolerated treatment for PsA. 48% of patients experienced a reduction of ≥50% based on PASI scores. 77% of the patients achieved a PsARC response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Efficacy of methotrexate in management of peripheral psoriatic arthritis - a systematic review.

Author: RuhoffJosephine Thusgaard, HornHans Christian, EllingsenTorkell

Disease modification

Psoriatic arthritis (PsA) is a chronic inflammatory joint disease that affects people with psoriasis. Methotrexate (MTX) is often the first choice for treatment, but there is limited research on its effectiveness. This review examines the available evidence on the effects of MTX for PsA affecting the joints in the arms and legs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Treatment-to-Target With Apremilast in Psoriatic Arthritis: The Probability of Achieving Targets and Comprehensive Control of Disease Manifestations.

Author: MeasePhilip J, GladmanDafna D, OgdieAlexis, CoatesLaura C, BehrensFrank, KavanaughArthur, McInnesIain, QueiroRubén, GueretteBenoit, BrunoriMichele, TengLichen, SmolenJosef S

Improved PsA treatment

This study evaluated the probability of achieving remission or low disease activity (LDA) with apremilast in treating psoriatic arthritis (PsA), considering different disease activity categories and responses in various domains of PsA.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

87.

Prognostic factors of good response to DMARDs in psoriatic arthritis: a narrative review.

Author: MekhailChristine, ChoukMickaël, PratiClément, WendlingDaniel, VerhoevenFrank

A review of literature on psoriatic arthritis (PsA) treatment suggests that dactylitis and axial involvement are associated with poor response to methotrexate, leflunomide is more effective in polyarticular involvement, TNF inhibitors are preferred for young men with elevated CRP, and apremilast and ustekinumab are more effective in mono and oligo articular disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

Pharmacological treatment of psoriatic arthritis: a systematic literature research for the 2019 update of the EULAR recommendations for the management of psoriatic arthritis.

Author: KerschbaumerAndreas, SmolenJosef S, DougadosMaxime, de WitMaarten, PrimdahlJette, McInnesIain, van der HeijdeDésirée, BaraliakosXenofon, FalzonLouise, GossecLaure

PsA treatment
Cardiovascular events
Infections
Infusion reactions
Malignancies
Multiple sclerosis

Numerous disease-modifying antirheumatic drugs (DMARDs) have demonstrated efficacy in treating psoriatic arthritis (PsA), with varying effectiveness across manifestations. Safety considerations, including the risk of venous thromboembolic events with Janus kinase inhibitors, are crucial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Secukinumab versus adalimumab for treatment of active psoriatic arthritis (EXCEED): a double-blind, parallel-group, randomised, active-controlled, phase 3b trial.

Author: McInnesIain B, BehrensFrank, MeasePhilip J, KavanaughArthur, RitchlinChristopher, NashPeter, MasmitjaJordi Gratacós, GoupillePhilippe, KorotaevaTatiana, GottliebAlice B, MartinRuvie, DingKevin, PelletPascale, MpofuShephard, PricopLuminita,

Improved PsA treatment

This study (EXCEED) evaluates the efficacy and safety of secukinumab versus adalimumab as first-line biological monotherapy for psoriatic arthritis.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

90.

Fourteen small molecule and biological agents for psoriatic arthritis: A network meta-analysis of randomized controlled trials.

Author: QiuMingliang, XuZhongbo, GaoWenjuan, XiongMeizhen, WenXianhua, ZhuWeina, ZhouXu, YuMinfeng

PsA treatment
serious adverse events

This network meta-analysis compared the efficacy and safety of 14 small molecule and biological agents for the treatment of psoriatic arthritis (PsA). Analysis of 30 studies involving 10,191 patients found that etanercept (ETN) and infliximab (IFX) were the most effective treatments for improving ACR20 response, while IFX was superior for PASI75 response. ABT-122 exhibited the best safety profile. Gol, ETN, and IFX emerged as the top 3 treatments based on both efficacy and safety considerations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

Association of previous treatment with anti-tumour necrosis factor inhibitors with the effectiveness of secukinumab in the treatment of psoriatic arthritis: systematic review and meta-analysis.

Author: XuYantao, LiYuting, DongMengyuan, GaoZi'ang, ChenXiang, LiuHong, ShenMinxue

PsA treatment
TNFi switching
Poorer response (TNFi history)

Secukinumab is less effective in psoriatic arthritis (PsA) patients who previously received TNFs inhibitor (TNFi) treatment compared to TNFi-naïve patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Upadacitinib for psoriatic arthritis refractory to biologics: SELECT-PsA 2.

Author: MeasePhilip J, LertratanakulApinya, AndersonJaclyn K, PappKim, Van den BoschFilip, TsujiShigeyoshi, DokoupilovaEva, KeisermanMauro, WangXin, ZhongSheng, McCaskillReva M, ZuegerPatrick, PanganAileen L, TillettWilliam

ACR20 response
PsA treatment
Serious infections

A randomized, placebo-controlled trial of 642 patients with psoriatic arthritis (PsA) who had inadequate response or intolerance to at least one biologic disease-modifying antirheumatic drug (DMARD) evaluated the efficacy of upadacitinib. Both upadacitinib 15 mg and 30 mg were more effective than placebo in improving signs and symptoms of PsA over 24 weeks. The rates of treatment-emergent adverse events were generally similar to placebo for upadacitinib 15 mg, while upadacitinib 30 mg was associated with higher rates.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

93.

Efficacy of Tofacitinib in the Treatment of Psoriatic Arthritis: A Systematic Review.

Author: Gratacós MasmitjàJordi, González FernándezCarlos M, Gómez CastroSusana, Rebollo LasernaFrancisco José

PsA treatment

Psoriatic arthritis (PsA) is treated with a variety of approaches, including lifestyle changes, pain relief medications, and targeted drugs that suppress the immune system. This review will summarize the latest research on the effectiveness of tofacitinib, a medication that blocks a specific enzyme, for treating PsA, focusing on how well it works for joint problems, spine problems, inflammation in tendons, and inflammation in fingers and toes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Are biologics combined with methotrexate better than biologics monotherapy in psoriasis and psoriatic arthritis: A meta-analysis of randomized controlled trials.

Author: XieYan, LiuYang, LiuYi

Biologics plus MTX for psoriasis
No significant difference for PsA treatment

This systematic review compares the efficacy and safety of biologics plus methotrexate (MTX) versus biologic monotherapy for psoriasis and psoriatic arthritis (PsA), finding that the combination group showed better improvement for psoriasis but not for PsA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

95.

Management of particular clinical situations in psoriatic arthritis: an expert's recommendation document based on systematic literature review and extended Delphi process.

Author: García-VicuñaRosario, GarridoNoemí, GómezSusana, JovenBeatriz, QueiroRubén, RamírezJulio, RebolloFrancisco, LozaEstíbaliz, SellasAgustí

PsA management recommendations

This study developed practical recommendations for managing patients with psoriatic arthritis (PsA) with specific clinical situations, considering the efficacy and safety of different medications and the need for individualized treatment approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

JAK inhibitors and psoriatic arthritis: A systematic review and meta-analysis.

Author: CampanaroFrancesco, BatticciottoAlberto, ZaffaroniAndrea, CappelliAntonella, DonadiniMarco Paolo, SquizzatoAlessandro

PsA treatment

While treatments for psoriatic arthritis (PsA) have improved in recent years, there's still a need for better options. This study examines the effectiveness and safety of JAK inhibitors, a new type of medication that targets specific pathways involved in PsA. The study focuses on two JAK inhibitors, tofacitinib and upadacitinib, which were recently approved for PsA treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Brazilian Society of Rheumatology 2020 guidelines for psoriatic arthritis.

Author: CarneiroSueli, PalominosPenelope Esther, AntiSônia Maria Alvarenga, AssadRodrigo Luppino, GonçalvesRafaela Silva Guimarães, ChiereghinAdriano, LyrioAndre Marun, XimenesAntônio Carlos, SaadCarla Gonçalves, GonçalvesCélio Roberto, KohemCharles Lubianca, MarquesCláudia Diniz Lopes, SchainbergCláudia Goldenstein, de Souza MeirellesEduardo, ResendeGustavo Gomes, PieruccettiLenise Brandao, KeisermanMauro Waldemar, YazbekMichel Alexandre, Sampaio-BarrosPercival Degrava, da Cruz LageRicardo, BonfiglioliRubens, OliveiraThauana Luíza, AzevedoValderílio Feijó, BianchiWashington Alves, BernardoWanderley Marques, Dos Santos SimõesRicardo, de Medeiros PinheiroMarcelo, CampanholoCristiano Barbosa

PsA treatment

This updated set of guidelines for managing psoriatic arthritis (PsA) provides evidence-based recommendations for diagnosis, non-medication treatments, conventional medications, and biological therapies. The guidelines are based on a review of 191 research studies and provide recommendations on how to best treat PsA, a chronic inflammatory condition that affects the joints and skin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

Successful IL-17A inhibitor cycling in psoriatic arthritis patient: a case report and a literature review.

Author: BarešićMarko, Smiljanić TomičevićLjiljana, AnićBranimir, MayerMiroslav

Psoriatic arthritis treatment

Psoriatic arthritis (PsA) can affect different parts of the body, and treatment depends on which parts are most affected. This report describes a case of a man with all six main features of PsA who didn't respond to standard medications, light therapy, or topical treatments. He improved with a medication called golimumab but then stopped responding. Another medication called secukinumab was tried, but it also stopped working. He then responded well to a third medication called ixekizumab. This suggests that switching between different medications that target a specific protein in the immune system (IL-17A inhibitors) might be a good treatment option for some people with challenging PsA.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

99.

Baseline Disease Activity Predicts Achievement of cDAPSA Treatment Targets With Apremilast: Phase III Results in DMARD-naïve Patients With Psoriatic Arthritis.

Author: MeasePhilip J, KavanaughArthur, OgdieAlexis, WellsAlvin F, BergmanMartin, GladmanDafna D, RichterSven, TengLichen, JardonShauna, SmolenJosef S

Apremilast efficacy
PsA treatment

This study investigated the likelihood of achieving specific treatment goals for psoriatic arthritis (PsA) with apremilast, a medication, in patients who hadn't previously taken other medications for PsA. The study looked at how the severity of the disease at the start of treatment influenced the chances of achieving remission or low disease activity.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

100.

Does previous use of tumour necrosis inhibitors change the therapeutic effect of interleukin (IL)-17 or IL-12/23 inhibitors on psoriasis and psoriatic arthritis? Results of a systematic review.

Author: XieYan, LiuYang

IL-12/23 efficacy
IL-17A efficacy
Lower efficacy in TNFi-experienced

Interleukin (IL)-17 and IL-12/23 inhibitors showed efficacy in patients with psoriasis or psoriatic arthritis who were intolerant of or had responded inadequately to tumor necrosis factor inhibitor (TNFi) therapy. However, efficacy was lower than that in TNFi-naïve patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

101.

Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial.

Author: BrunnerHermine I, FoeldvariIvan, AlexeevaEkaterina, AyazNuray Aktay, Calvo PenadesInmaculada, KasapcopurOzgur, ChasnykVyacheslav G, HufnagelMarkus, ŻuberZbigniew, SchulertGrant, OzenSeza, RakhimyanovaAdelina, RamananAthimalaipet, ScottChristiaan, SozeriBetul, ZholobovaElena, MartinRuvie, ZhuXuan, WhelanSarah, PricopLuminita, MartiniAlberto, LovellDaniel, RupertoNicolino,

Disease flare reduction
Safety profile

Secukinumab demonstrated significantly longer time to disease flare than placebo in children with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) with a consistent safety profile.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

102.

Management of Axial Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

Author: LubranoEnnio, ChanJon, Queiro-SilvaRuben, CauliAlberto, GoelNiti, PoddubnyyDenis, NashPeter, GladmanDafna D

PsA treatment

Psoriatic arthritis (PsA) can affect the spine, but there's no clear definition of what defines spine involvement. This study will review research on different treatments for spine problems in PsA, examining how well they work.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

103.

Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

Author: CampanholoCristiano B, MaharajAjesh B, CorpNadia, BellStacie, CostaLuisa, de VlamKurt, GullickNicola J, KhraishiMajed, KishimotoMitsumasa, Palmou-FontanaNatalia, ReddySoumya, ScarpaRaffaele, VegaLuis, DuarteGleison Vieira, ZismanDevy, van der WindtDanielle A, DuruozMehmet T, OgdieAlexis

PsA treatment

New treatment recommendations for psoriasis and psoriatic arthritis (PsA) provide guidance for choosing the right treatment based on each person's condition. In addition to specific features of the disease and related problems like eye inflammation and inflammatory bowel disease, other health conditions (comorbidities) also need to be considered when choosing the best treatment.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

104.

Management of Nail Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

Author: LaheruDhruvkumar, AntonyAnna, CarneiroSueli, Di LerniaVito, GargAmit, LoveThorvardur Jon, Del Rocio Macias GarciaKarla, MendonçaJosé Alexandre, MukherjeeSandeep, OlteanuRodica, Perez-ChadaLourdes, RosenCheryl F, TannenbaumRachel, YazbekMichel Alexandre

Nail psoriasis treatment

This systematic literature review examines the updated evidence since the last GRAPPA nail psoriasis treatment recommendations published in 2014. It finds insufficient evidence to support any recommendation for the use of topical corticosteroids, topical calcipotriol, topical tazarotene, topical cyclosporine, dimethyl fumarates/fumaric acid esters, phototherapy, and alitretinoin. However, the highest strength of supporting evidence is for the recommendation of biologic agents including tumor necrosis factor inhibitors, and interleukin 12/23, 17, and 23 inhibitors.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

105.

Biomarkers in psoriatic arthritis: A meta-analysis and systematic review.

Author: WirthTheo, BalandraudNathalie, BoyerLaurent, LafforguePierre, PhamThao

PsA diagnosis
PsA treatment

Psoriatic arthritis (PsA) is a chronic inflammatory disease that can develop in people with psoriasis or on its own. Because the symptoms can be varied, it's often diagnosed late, leading to damage to joints and tendons. This delays treatment and impacts quality of life. New research is focusing on identifying markers to diagnose PsA early and improve outcomes.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

108.

Lifestyle Modifications and Nonpharmacologic Interventions to Improve Outcomes in Psoriatic Arthritis: A Systematic Review.

Author: HaileyLouise H, AmarnaniRaj, BundyChris, McGaghDylan, JamesLija, KirtleyShona, O'SullivanDenis, SteinkoenigIngrid, SuribhatlaRhea, VivekananthamArani, CoatesLaura C

PsA treatment

This systematic review explores lifestyle modifications and nonpharmacologic and psychological interventions for managing psoriatic arthritis (PsA). While drug treatments are recommended, there is limited guidance for nonpharmacologic approaches.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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