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Acute effects of sumatriptan on aortic blood pressure, stiffness, and pressure waveform.

Author: VanmolkotFloris H M, de HoonJan N J M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sumatriptan, a 5-hydroxytryptamine (HT)(1B/1D) receptor agonist, is effective for acute migraines but contraindicated in high-risk cardiovascular patients due to its vasoconstrictor activity. The study investigated the effects of sumatriptan on aortic blood pressure, stiffness, and pressure waveform.
Paper Details　
Original Abstract of the Article :
Sumatriptan, a 5-hydroxytryptamine (HT)(1B/1D) receptor agonist, is an effective acute antimigraine drug. Because of its vasoconstrictor activity, it is contraindicated in patients at high risk for adverse cardiovascular events. Acute antimigraine drugs without vasoconstrictor effects are currently ...See full text at original site
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引用元：
https://doi.org/10.1016/j.clpt.2006.03.011

データ提供：米国国立医学図書館（NLM）

Sumatriptan: A Closer Look at Its Cardiovascular Effects

This research explores the effects of sumatriptan, a common migraine treatment, on aortic blood pressure, stiffness, and pressure waveform. This is like investigating the impact of a desert wind on the delicate balance of a fragile ecosystem, understanding how a single factor can influence a complex system.

Sumatriptan: A Double-Edged Sword

The study reveals that sumatriptan has vasoconstrictor effects, raising concerns about its safety for individuals with cardiovascular risks. This is like observing a desert bloom that may appear beautiful but also harbors hidden dangers. The authors highlight the need for caution when using sumatriptan, particularly for those with pre-existing cardiovascular conditions.

Navigating the Desert of Migraine Treatment

The study emphasizes the importance of careful monitoring and informed decision-making when treating migraine headaches. This is like choosing a safe path through a desert with hidden dangers, carefully considering the potential risks and benefits of each route. The authors encourage further research to develop migraine treatments that are both effective and safe for patients, particularly those with cardiovascular vulnerabilities.

Dr. Camel's Conclusion

This research is a reminder that even seemingly simple treatments can have complex and sometimes unforeseen effects. It emphasizes the importance of thorough research and careful evaluation before any new drug or therapy is introduced. It's like navigating a desert landscape, where every step must be taken with awareness and caution, ensuring that our journey is safe and beneficial.
Date :
  1. Date Completed 2006-08-03
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

16815320

DOI: Digital Object Identifier

10.1016/j.clpt.2006.03.011

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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