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Effects of single doses of rabeprazole 20 mg and esomeprazole 40 mg on 24-h intragastric pH in healthy subjects.

Author: BaisleyKathy, BoyceMalcolm, DunnKate, MorocuttiAnna, WarringtonSteve

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A single dose of rabeprazole 20 mg was as effective as esomeprazole 40 mg in increasing intragastric pH, despite the 2-fold difference in dose.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare antisecretory effects of single doses of rabeprazole and esomeprazole. METHODS: Open, randomised, 2-way crossover, clinical pharmacology study. 24 healthy subjects (10 men; mean age 26.2 y) received a single dose of rabeprazole 20 mg or esomeprazole 40 mg, with a 14-day 'washo...See full text at original site
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引用元：
https://doi.org/10.1007/s00228-006-0148-5

データ提供：米国国立医学図書館（NLM）

The Antisecretory Effects of Rabeprazole and Esomeprazole: A Camel Race in the Stomach

The world of medicine is a vast desert, filled with countless mysteries to unravel. One such mystery lies in the stomach, where acid plays a vital role in digestion. But sometimes, this acid can cause discomfort and even damage. This study delves into the desert of gastric acid regulation, comparing two drugs, rabeprazole and esomeprazole, used to reduce acid production.

The researchers measured the intragastric pH levels in healthy volunteers after they received single doses of rabeprazole or esomeprazole. They found that both drugs effectively increased pH levels, reducing the acidity in the stomach. It's like having two camels racing across the desert, both striving to reach the oasis of neutrality, where the stomach is comfortable and balanced.

Comparing Antisecretory Effects: A Close Race for the Oasis

This study shows that both rabeprazole and esomeprazole are effective in reducing stomach acidity. The researchers found that rabeprazole, even at a lower dose, was just as effective as esomeprazole. It's like a close race between two equally skilled camels, with both reaching the oasis at roughly the same time.

Understanding Gastric Acid Regulation: A Journey into the Stomach

This study provides valuable insight into the mechanisms by which these drugs work. It also highlights the importance of understanding the nuances of gastric acid regulation for developing effective treatments for acid-related conditions. Think of it as exploring the intricate pathways of the desert, gaining knowledge about its hidden wonders and the forces that shape its landscape.

Dr.Camel's Conclusion

This research sheds light on the efficacy of rabeprazole and esomeprazole in managing gastric acidity. It's a testament to the power of scientific inquiry to unlock the secrets of the body and develop effective treatments for common ailments.

Date :
  1. Date Completed 2007-02-20
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

16850327

DOI: Digital Object Identifier

10.1007/s00228-006-0148-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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