Effects of esomeprazole: A Synthesis of Findings from 4 Studies

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Original Abstract of the Article

Major Research Findings

Esomeprazole has been shown to be effective in treating frequent heartburn over 14 days. 2 Additionally, esomeprazole has been found to be more effective in suppressing gastric acid secretion than rabeprazole. 1 Furthermore, esomeprazole has been shown to be effective not only when administered orally but also intravenously and subcutaneously. 3 Moreover, esomeprazole has been shown to be more effective in suppressing gastric acid secretion than famotidine. 4

Benefits and Risks

Benefit Summary

Esomeprazole has been shown to be effective in treating frequent heartburn. Additionally, esomeprazole has been found to be more effective in suppressing gastric acid secretion than rabeprazole. Esomeprazole has been shown to be effective not only when administered orally but also intravenously and subcutaneously. Moreover, esomeprazole has been shown to be more effective in suppressing gastric acid secretion than famotidine.

Risk Summary

There were no detailed reports on the risks of esomeprazole in each study. Esomeprazole is generally considered a safe drug. However, there is always the possibility of side effects, so it is important to take it according to your doctor's instructions.

Comparison Between Studies

Commonalities

All studies showed that esomeprazole has a gastric acid-suppressing effect. Also, all studies suggest that esomeprazole is a safe drug.

Differences

Each study differs in the route of administration and the comparative drug used for esomeprazole. 2 evaluates the effects of oral administration of esomeprazole. 1 compares esomeprazole to rabeprazole and evaluates the gastric acid suppression effects. 3 evaluates the effects of oral, intravenous, and subcutaneous administration of esomeprazole. 4 compares esomeprazole to famotidine and evaluates the gastric acid suppression effects.

Consistency and Contradictions

These studies showed that esomeprazole has a gastric acid-suppressing effect. The results of all studies are consistent and there are no contradictions. Each study used different routes of administration and comparative drugs, but they all reached the result that esomeprazole has a gastric acid-suppressing effect.

Precautions for Real-World Applications

Esomeprazole may be effective in treating frequent heartburn. However, it is important to take esomeprazole according to your doctor's instructions. Esomeprazole is not effective for all causes of heartburn. Also, esomeprazole may have side effects. Consult your doctor before taking esomeprazole.

Limitations of Current Research

These studies evaluated the short-term effects of esomeprazole. There is a lack of studies evaluating the long-term effects of esomeprazole. Also, these studies were conducted on specific patient populations and may not be applicable to all patients.

Future Research Directions

Research is needed to evaluate the long-term effects of esomeprazole. Studies evaluating the effects of esomeprazole in different patient populations are needed. Additionally, research is needed to evaluate the side effects of esomeprazole.

Conclusion

Esomeprazole has been shown to have gastric acid-suppressing effects. Esomeprazole may be effective in treating frequent heartburn. However, it is important to take esomeprazole according to your doctor's instructions. Research is needed to evaluate the long-term effects and side effects of esomeprazole.

Literature analysis of 4 papers
Positive Content
4
Neutral Content
0
Negative Content
0
Article Type
4
0
0
0
4
1.

Effects of single doses of rabeprazole 20 mg and esomeprazole 40 mg on 24-h intragastric pH in healthy subjects.

Author: WarringtonSteve, BaisleyKathy, DunnKate, BoyceMalcolm, MorocuttiAnna

Effective in increasing intragastric pH
Well tolerated

A single dose of rabeprazole 20 mg was as effective as esomeprazole 40 mg in increasing intragastric pH, despite the 2-fold difference in dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

A 14-day regimen of esomeprazole 20 mg/day for frequent heartburn: durability of effects, symptomatic rebound, and treatment satisfaction.

Author: PeuraDavid, Le MoigneAnne, PollackCharles, NagyPeter, LindTore

Effective treatment
Esomeprazole for heartburn

Esomeprazole 20 mg once daily is effective for treating frequent heartburn in subjects who may self-treat with over-the-counter medications. This study also assessed the effects of esomeprazole 20 mg once daily for 14 days on treatment satisfaction, rescue antacid use, and the durability of its effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Comparison of the acid suppression effects between low-dose esomeprazole and famotidine in healthy subjects.

Author: KimHa-Yeon, HwangJun Gi, KimJae-Won, SeongChang Hwan, LeeJi Hyeon, ChoiYoung-Sim, MinHyo Jin, KimHyung Son, KimHye Yun, KimYu Kyong, ParkMin Kyu

Low-dose esomeprazole gastritis treatment

This study aimed to compare the efficacy of low-dose esomeprazole and famotidine in treating gastritis. The pharmacodynamic properties of both drugs were also explored.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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