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Ischemic necrosis and atrophy of the optic nerve after periocular carboplatin injection for intraocular retinoblastoma.

Author: AabergThomas M, GrossniklausHans E, HubbardG Baker, KangShin J, SchmackIngo

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Periocular injections of carboplatin may be useful for advanced intraocular retinoblastoma but can lead to ischemic optic neuropathy. Ophthalmologists and pediatric oncologists should be aware of this potential complication.
Paper Details　
Original Abstract of the Article :
PURPOSE: To report four cases of optic nerve neuropathy in three children treated with periocular carboplatin injections for unilateral or bilateral intraocular retinoblastoma. DESIGN: Retrospective, observational case series. SETTING: University-based Ophthalmology Practice. STUDY POPULATION: Fo...See full text at original site
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引用元：
https://doi.org/10.1016/j.ajo.2006.02.044

データ提供：米国国立医学図書館（NLM）

A Warning in the Desert of Retinoblastoma Treatment

Retinoblastoma, a cancer of the eye, can be a challenging condition to treat. This research explores the use of periocular carboplatin injections as a potential treatment option for retinoblastoma. While this approach can be effective, it comes with a potential risk that must be carefully considered, like a hidden mirage in a seemingly safe desert oasis.

A Potential Side Effect: Ischemic Optic Neuropathy

This study reports four cases of optic nerve neuropathy in children who received periocular carboplatin injections for retinoblastoma. While carboplatin can be a valuable tool in the fight against retinoblastoma, this research highlights the importance of being aware of its potential side effects. This knowledge is essential for making informed treatment decisions and ensuring the safety of young patients.

Navigating the Desert of Retinoblastoma Treatment

This study underscores the need for careful consideration of treatment options for retinoblastoma. While periocular carboplatin injections can be effective, the risk of ischemic optic neuropathy must be weighed against its potential benefits. Further research is needed to optimize this approach and minimize the risk of complications.

Dr.Camel's Conclusion

This research serves as a reminder that the desert of cancer treatment can be filled with unexpected dangers, even when using seemingly safe and effective treatments. It's important to be aware of potential side effects and to carefully weigh the risks and benefits of each treatment option.

Date :
  1. Date Completed 2006-08-29
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

16876514

DOI: Digital Object Identifier

10.1016/j.ajo.2006.02.044

Related Literature

Article Analysis
・Side Effects of carboplatin injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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