Side Effects of carboplatin injection: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Main Research Findings

Carboplatin is an anticancer drug used to treat eye tumors such as retinoblastoma. Carboplatin solution is suggested to be as effective and have similar side effects as carboplatin powder compared to carboplatin powder. 5

Periocular carboplatin injection is effective in treating retinoblastoma, but there is a risk of side effects such as optic neuropathy. 4

Periocular carboplatin injection is suggested to be as safe and effective as intravitreal melphalan injection in the management of retinoblastoma (RB) with secondary vitreous seeds. Carboplatin injection may be more effective in treating retinoblastoma than melphalan injection and may have fewer side effects than melphalan injection. 2

Carboplatin injection can cause inflammation in the periocular tissues. 3

Reasons for Side Effects

Carboplatin is an anticancer drug that inhibits the growth of cancer cells. Carboplatin can affect normal cells as well as cancer cells, and this is thought to be the cause of side effects.

Common Side Effects

Periocular inflammation

It can cause inflammation in the tissues around the eye socket. 3

Optic neuropathy

There is a risk of side effects such as optic neuropathy. 4

Vitreous seeds regression

Vitreous seeds regression is one of the outcome measures in a study comparing posterior sub-Tenon's carboplatin injection with intravitreal melphalan therapy in the management of retinoblastoma (RB) with secondary vitreous seeds. 2

Need for other treatment modalities

Another outcome measure in a study comparing posterior sub-Tenon's carboplatin injection with intravitreal melphalan therapy in the management of retinoblastoma (RB) with secondary vitreous seeds is the need for other treatment modalities to achieve ocular salvage. 2

Countermeasures for Side Effects

Countermeasures for periocular inflammation

Periocular inflammation may be improved with drug treatment such as steroids.

Countermeasures for optic neuropathy

Optic neuropathy may improve by stopping carboplatin administration. However, if severe, it may leave sequelae such as visual impairment.

Comparison between Studies

Common points in the studies

Carboplatin is suggested to be an effective drug for the treatment of eye tumors.

Differences between studies

Comparative studies of carboplatin solution and powder suggest that carboplatin solution is as effective and has similar side effects compared to powder. However, comparative studies of carboplatin solution and powder are small studies involving a limited number of patients, and larger studies are needed.

Precautions for Application in Real Life

Carboplatin is an effective drug for the treatment of eye tumors, but there is a risk of side effects. Always consult a doctor before taking carboplatin.

Limitations of Current Research

Carboplatin is a new drug used to treat eye tumors, and there has not been much research yet. Therefore, many studies on carboplatin are small studies involving a limited number of patients, and large-scale studies and long-term studies are needed.

Future Research Directions

Carboplatin is an effective drug for the treatment of eye tumors, and it is hoped that future research will clarify its safety and effectiveness. In particular, further research is needed, such as comparative studies of carboplatin solution and powder, and comparative studies of carboplatin and other treatments.

Conclusion

Carboplatin is an effective drug for the treatment of eye tumors, but there is a risk of side effects. Always consult a doctor before taking carboplatin. It is hoped that future research will clarify the safety and effectiveness of carboplatin.

Literature analysis of 5 papers
Positive Content
3
Neutral Content
0
Negative Content
2
Article Type
1
1
1
0
5
1.

Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis.

Author: LattanziSimona, BrigoFrancesco, TrinkaEugen, ZaccaraGaetano, CagnettiClaudia, Del GiovaneCinzia, SilvestriniMauro

Anti-seizure properties
Abuse liability

Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, shows promise as a new therapeutic option for epilepsy. CBD exhibits anti-seizure properties through multiple mechanisms, including modulation of ionic channels and neurotransmitter transporters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Severe aseptic orbital cellulitis with subtenon carboplatin for intraocular retinoblastoma.

Author: ShahParag K, KalpanaN, NarendranV, RamakrishnanMinu

Orbital cellulitis

This case report describes a patient who developed severe aseptic orbital cellulitis with necrosis and prolapse of the conjunctiva 48 hours after subtenon carboplatin injection. The condition resolved with conservative management.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Ischemic necrosis and atrophy of the optic nerve after periocular carboplatin injection for intraocular retinoblastoma.

Author: SchmackIngo, HubbardG Baker, KangShin J, AabergThomas M, GrossniklausHans E

Ischemic optic neuropathy

Periocular injections of carboplatin may be useful for advanced intraocular retinoblastoma but can lead to ischemic optic neuropathy. Ophthalmologists and pediatric oncologists should be aware of this potential complication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

[A comparative clinical study of carboplatin solution and carboplatin powder].

Author: LiQ, ZhouJ, QuF

Cancer treatment
Gastrointestinal reactions
Myelosuppression

Carboplatin solution was as effective as carboplatin powder in the treatment of small cell lung cancer, non-small cell lung cancer, and breast cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

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