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CD4-guided scheduled treatment interruptions compared with continuous therapy for patients infected with HIV-1: results of the Staccato randomised trial.

Author: , AnanworanichJintanat, BernasconiEnos, CavassiniMatthias, ChetchotisakdPloenchan, CooperDavid, FurrerHansjakob, Gayet-AgeronAngèle, GennéDaniel, HillAndrew, HirschelBernard, KarrerUrs, KiertiburanakulSasisopin, Le BrazMichelle, LeducDominic, MunsakulWarangkana, NüeschReto, PernegerThomas, PerrinLuc, PhanuphakPraphan, PrasithsirikulWisit, RaksakulkarnPhitsanu, RuxrungthamKiat, SatchellClaudette, SirivichayakulSunee, TansuphasawasdikulSomboon, VernazzaPietro, YerlySabine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Scheduled treatment interruptions for HIV-1 infection resulted in substantial drug savings and no evidence of increased treatment resistance. Treatment-related adverse events were more frequent with continuous treatment, but low CD4 counts and minor manifestations of HIV infection were more frequent with scheduled treatment interruption.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Stopping antiretroviral therapy in patients with HIV-1 infection can reduce costs and side-effects, but carries the risk of increased immune suppression and emergence of resistance. METHODS: 430 patients with CD4-positive T-lymphocyte (CD4) counts greater than 350 cells per muL, and vir...See full text at original site
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引用元：
https://doi.org/10.1016/S0140-6736(06)69153-8

データ提供：米国国立医学図書館（NLM）

HIV Treatment Interruptions: A Strategic Approach to Management

The field of [HIV/AIDS] is constantly evolving, with new strategies for managing the disease emerging all the time. This research investigates the effectiveness of [scheduled treatment interruptions] in patients with [HIV-1] infection who have achieved [viral suppression] and have [high CD4 counts]. The researchers compared a group of patients who received [scheduled treatment interruptions] with a group who received [continuous therapy].

The study found that [scheduled treatment interruptions] resulted in significant drug savings without compromising viral suppression or increasing the risk of treatment resistance. This discovery offers a potential strategy for optimizing [HIV] treatment, balancing the need for effective medication with the desire to minimize side effects and costs.

A Balancing Act: Treatment Interruptions and HIV Management

This research highlights the potential benefits of [scheduled treatment interruptions] in managing [HIV-1] infection in patients who have achieved [viral suppression] and have [high CD4 counts]. The findings suggest that this strategy can be effective in reducing drug use and costs without compromising viral suppression.

Tailoring Treatment: Optimizing HIV Management Strategies

This research underscores the importance of tailoring [HIV] treatment strategies to individual patient needs. The study's findings suggest that [scheduled treatment interruptions] could be a viable option for certain patients, potentially improving their quality of life and reducing the burden of treatment.

Dr. Camel's Conclusion

This research explores the effectiveness of [scheduled treatment interruptions] in managing [HIV-1] infection. The study's findings suggest that this strategy can be effective in reducing drug use and costs without compromising viral suppression or increasing the risk of treatment resistance. This research highlights the importance of tailoring treatment strategies to individual patient needs and optimizing [HIV] management for improved patient outcomes.

Date :
  1. Date Completed 2006-08-22
  2. Date Revised 2015-06-16
Further Info :

Pubmed ID

16890832

DOI: Digital Object Identifier

10.1016/S0140-6736(06)69153-8

SNS
PICO Info
in preparation
Languages

English

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