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A protective role for keratinocyte growth factor in a murine model of chemotherapy and radiotherapy-induced mucositis.

Author: BorgesLuis, ChenJennifer N, FarrellCatherine L, KaufmanStephen, PretoriusJames K, RexKaren L, ScullySheila, WeiPing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Palifermin (rHuKGF) administration before and after radiotherapy/chemotherapy (RT/CT) mitigates weight loss and has a trophic effect on the intestinal mucosa and salivary glands, suggesting that palifermin use should be investigated further in the RT/CT setting.
Paper Details　
Original Abstract of the Article :
PURPOSE: To evaluate the activity of palifermin (rHuKGF) in a murine model of mucosal damage induced by a radiotherapy/chemotherapy (RT/CT) regimen mimicking treatment protocols used in head-and-neck cancer patients. METHODS AND MATERIALS: A model of mucosal damage induced by RT/CT was established ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijrobp.2006.05.025

データ提供：米国国立医学図書館（NLM）

Palifermin: A Potential Protective Agent for Chemotherapy and Radiotherapy-Induced Mucositis

Cancer treatment, particularly chemotherapy and radiotherapy, can have significant side effects, including mucositis, a painful inflammation of the mucous membranes. This research investigates the potential of palifermin, a keratinocyte growth factor, to protect against mucositis in a mouse model.

Palifermin: A Potential Oasis for Mucositis

The research reveals that palifermin administration before and after a chemotherapy and radiotherapy regimen significantly reduces mucositis in mice, promoting cell proliferation and increasing epithelial thickness. This finding is like discovering a hidden oasis in the desert of cancer treatment side effects, offering a potential solution for alleviating the discomfort and complications of mucositis.

The Promise of Palifermin for Cancer Patients

This research highlights the potential of palifermin as a protective agent against mucositis, a debilitating side effect of cancer treatment. Just as a camel needs to be protected from the harsh elements of the desert, cancer patients undergoing chemotherapy and radiotherapy need strategies to mitigate the potential side effects of treatment.

Dr.Camel's Conclusion

The desert of cancer treatment can be a harsh and unforgiving landscape, often accompanied by debilitating side effects. This research offers a glimmer of hope, suggesting that palifermin may provide a much-needed oasis for patients experiencing mucositis. By exploring new avenues for reducing treatment-related side effects, we can create a more compassionate and supportive journey for those battling cancer.

Date :
  1. Date Completed 2006-09-21
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

16904525

DOI: Digital Object Identifier

10.1016/j.ijrobp.2006.05.025

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in preparation
Languages

English

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