Low-dose acitretin is associated with fewer adverse events than high-dose acitretin in the treatment of psoriasis.

Author: FeldmanSteven R, KlingerStephen, MuradEmma J, PearceDaniel J, RowellRichard, ZielKristin K

Paper Details 
Original Abstract of the Article :
In practice, lower dose acitretin therapy (25 mg/d) seems to be better tolerated and associated with fewer abnormalities found after laboratory testing. Here we revisit the original phase 3 trials for acitretin to evaluate the evidence for low-dose therapy producing fewer adverse effects than the 50...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1001/archderm.142.8.1000

データ提供:米国国立医学図書館(NLM)

Navigating the Desert of Psoriasis Treatment

The treatment of psoriasis, like traversing the vast and sometimes harsh desert, presents its own unique challenges. This study explores the effectiveness of low-dose acitretin, a treatment option that offers a potentially smoother path through the sands of psoriasis management. The authors revisit original phase 3 trials to evaluate the evidence for low-dose therapy's impact on adverse effects compared to the higher dosage. They found that low-dose acitretin, like a cool breeze in the desert, appears to be better tolerated and associated with fewer abnormalities in lab testing.

A More Gentle Journey Through Psoriasis Treatment

This study, like a skilled caravan leader navigating the dunes, highlights the importance of individualized treatment approaches. The study's results suggest that low-dose acitretin may offer a more comfortable and potentially safer path towards managing psoriasis, reducing the burden of side effects and enhancing the overall well-being of patients.

Embracing a More Balanced Approach

This research emphasizes the need for a personalized approach to psoriasis treatment. The findings suggest that low-dose acitretin may be a more suitable option for some patients, allowing them to navigate the desert of psoriasis management with less discomfort. This study encourages a nuanced and patient-centered approach to treatment, ensuring that patients can find the most effective and comfortable path towards achieving optimal results.

Dr. Camel's Conclusion

This study's findings, like a well-placed oasis, offer a valuable resource for clinicians and patients alike, providing insights into the potential benefits of low-dose acitretin. It's important to note that while low-dose acitretin may be a more tolerable option, individual needs and responses can vary. Ultimately, finding the right treatment path is a journey that requires careful consideration, a compassionate guide, and a commitment to achieving the best possible outcomes.

Date :
  1. Date Completed 2006-09-11
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

16924049

DOI: Digital Object Identifier

10.1001/archderm.142.8.1000

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.