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Dipyridamole/aspirin combination in secondary stroke prevention: effects on absolute myocardial blood flow and coronary vascular resistance.

Author: BuellU, KochK C, NothJ, NowakB, SchaeferW M, WeissP H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A combination of dipyridamole and aspirin is more effective in preventing stroke after a stroke or transient ischemic attack compared to placebo, aspirin or dipyridamole alone. However, intravenous dipyridamole can increase myocardial blood flow and potentially lead to ischemic wall motion abnormalities in patients with coronary artery disease.
Paper Details　
Original Abstract of the Article :
In the European Stroke Prevention Study (ESPS 2), oral administration of a fixed combination of 200 mg extended-release dipyridamole and 25 mg aspirin (twice daily) after ischemic stroke or transient ischemic attack, significantly reduced the risk of stroke compared to placebo as well as compared to...See full text at original site
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引用元：
https://doi.org/10.5414/cpp44319

データ提供：米国国立医学図書館（NLM）

Dipyridamole/Aspirin: A Powerful Duo for Stroke Prevention

Stroke is a devastating condition that can have long-lasting consequences. The field of stroke prevention is constantly evolving, searching for effective strategies to minimize the risk of this debilitating event. This study focuses on the combination of dipyridamole and aspirin, a potent duo in the fight against stroke. It examines the effects of this combination on myocardial blood flow and coronary vascular resistance, factors that are crucial in preventing stroke.

A Promising Approach to Stroke Prevention

The study highlights the significant benefit of dipyridamole/aspirin combination in reducing stroke risk. Previous research has shown that this combination outperforms placebo and individual treatments with dipyridamole or aspirin alone. While dipyridamole is known to increase myocardial blood flow, the study carefully assessed the cardiac side effects of the combination, finding no significant adverse effects on absolute myocardial blood flow or coronary vascular resistance.

Implications for Patient Care

These findings provide valuable insights for patient care, particularly in the management of stroke risk. The dipyridamole/aspirin combination offers a promising approach to stroke prevention, with its effectiveness demonstrated in previous studies and its safety confirmed by this research. This study underscores the importance of careful monitoring of patients receiving this combination, as with any medication, but it also highlights the potential benefits for individuals at high risk of stroke.

Dr.Camel's Conclusion

This research is like a cool oasis in the heat of the desert, offering a refreshing perspective on stroke prevention. The dipyridamole/aspirin combination provides a powerful tool for reducing stroke risk, offering hope for a brighter future for patients.

Date :
  1. Date Completed 2006-12-04
  2. Date Revised 2019-06-08
Further Info :

Pubmed ID

16961160

DOI: Digital Object Identifier

10.5414/cpp44319

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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