Side Effects of aspirin and extended-release dipyridamole: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Main Research Findings

Several studies have shown that aspirin and extended-release dipyridamole are effective in preventing secondary stroke after a transient ischemic attack (TIA) or minor stroke. 4 , 5 , 6 , 3 , 8 These medications prevent the recurrence of stroke by inhibiting platelet aggregation and preventing blood clot formation.

The combination of aspirin and extended-release dipyridamole has been shown to significantly reduce the risk of stroke recurrence compared to aspirin alone. 6 , 3 , 8 However, this combination does not increase the bleeding risk compared to aspirin alone. 3 , 8

On the other hand, combining aspirin with clopidogrel increases the risk of bleeding, so this combination is not recommended. 5 , 6 , 3 , 8

Telmisartan is used to lower blood pressure, but has been shown to be ineffective in preventing stroke or TIA. 4

Reasons for Side Effects

Aspirin and extended-release dipyridamole can increase the risk of bleeding by inhibiting platelet aggregation. 6 , 3 , 8 Dipyridamole can also cause headaches. 3

Clopidogrel inhibits blood clotting and can increase the risk of bleeding. 6 , 3 , 8 Clopidogrel can also rarely cause serious hematological side effects. 4

Common Side Effects

Headache

Dipyridamole can cause headaches. 3 Headaches often occur soon after starting dipyridamole and may subside over time. 3

Bleeding

Aspirin, dipyridamole, and clopidogrel can increase the risk of bleeding. 6 , 3 , 8 Bleeding can occur anywhere in the body, including the digestive system, brain, and skin. 3

Gastrointestinal Side Effects

Aspirin can cause gastrointestinal side effects, such as stomach pain, gastric ulcers, and peptic ulcers. 1

Hematological Side Effects

Clopidogrel can rarely cause serious hematological side effects. 4

Side Effect Management

Headache

If you experience a severe headache, consult your doctor. 3 Your doctor may prescribe medication to relieve your headache.

Bleeding

If you suspect bleeding, consult your doctor immediately. 3 Severe bleeding may require emergency treatment.

Gastrointestinal Side Effects

If you are concerned about gastrointestinal side effects, consult your doctor. 1 Your doctor may prescribe medication to reduce side effects.

Hematological Side Effects

If you experience fever, sore throat, or easy bruising while taking clopidogrel, consult your doctor immediately. 4

Comparison Between Studies

Similarities

Many studies have shown that aspirin and extended-release dipyridamole significantly reduce the risk of stroke recurrence. 6 , 3 , 8 These medications also do not increase the bleeding risk compared to aspirin alone. 3 , 8

Differences

Some studies have shown differences in effectiveness between aspirin and extended-release dipyridamole and clopidogrel monotherapy. 4 , 5 , 6 , 3 , 8 Studies may also differ in the incidence and types of side effects reported. 4 , 1 , 7 , 2

Real-Life Application Precautions

While aspirin and extended-release dipyridamole are effective medications for preventing stroke or TIA, they also carry the risk of side effects. 6 , 3 , 8 If you are taking these medications, consult your doctor and understand the risks and benefits before taking them.

Current Research Limitations

The long-term efficacy and safety of aspirin and extended-release dipyridamole are not yet fully understood. 8 Further research is also needed to determine the optimal dosage and duration of these medications.

Future Research Directions

Research is needed to investigate the long-term efficacy and safety of aspirin and extended-release dipyridamole. 8 Research is also needed to determine the optimal dosage and duration of these medications.

Conclusion

Aspirin and extended-release dipyridamole are effective medications for preventing stroke or TIA, but they also carry the risk of side effects. 6 , 3 , 8 If you are taking these medications, consult your doctor and understand the risks and benefits before taking them.

In addition to medication therapy, lifestyle changes are important in preventing stroke or TIA. 5 Maintaining a healthy lifestyle, such as quitting smoking, dietary changes, and exercise, is essential.

Literature analysis of 8 papers
Positive Content
7
Neutral Content
0
Negative Content
1
Article Type
2
0
0
4
8
1.

Measurement of side effects of drugs.

Author: HuskissonE C, WojtulewskiJ A

Check list interference

Using a check list to collect side effects in a clinical trial may interfere with the reporting of known and unknown symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Anti-platelet effects of 100 mg alternate day oral aspirin: a randomized, double-blind, placebo-controlled trial of regular and enteric coated formulations in men and women.

Author: RidkerP M, HennekensC H, ToflerG H, LipinskaI, BuringJ E

Cardiovascular benefit
Reduced gastrointestinal symptoms

Further research is needed to determine the optimal dose of aspirin to produce a cardiovascular benefit while minimizing side effects, particularly in women.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Review and management of side effects associated with antiplatelet therapy for prevention of recurrent cerebrovascular events.

Author: GuthrieRobert

Reduced stroke risk
Bleeding risk
Headache risk

This article discusses the risk of secondary events following noncardioembolic ischemic stroke or transient ischemic attack (TIA), and the use of antiplatelet therapy to reduce this risk. The article also discusses the potential side effects of antiplatelet therapy, particularly bleeding, and strategies to reduce the risk of side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Update on antiplatelet agents, including MATCH, CHARISMA, and ESPRIT.

Author: SkliutMaryna, JamiesonDara G

Reduced stroke risk
Stroke prevention
Hemorrhage

Aspirin plus extended-release dipyridamole is effective in preventing recurrent ischemic stroke, while clopidogrel plus aspirin is not.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Antiplatelet agents and randomized trials.

Author: DienerHans-Christoph

Stroke prevention
Bleeding risk

Secondary stroke prevention after TIA or ischemic stroke includes antithrombotic therapy, risk factor management, and carotid stenosis treatment. Antiplatelet drugs such as aspirin, aspirin plus ER-DP, clopidogrel, or clopidogrel plus aspirin are options, with varying efficacy and bleeding risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Dipyridamole/aspirin combination in secondary stroke prevention: effects on absolute myocardial blood flow and coronary vascular resistance.

Author: SchaeferW M, KochK C, NowakB, NothJ, BuellU, WeissP H

Stroke prevention
Cardiac side effects

A combination of dipyridamole and aspirin is more effective in preventing stroke after a stroke or transient ischemic attack compared to placebo, aspirin or dipyridamole alone. However, intravenous dipyridamole can increase myocardial blood flow and potentially lead to ischemic wall motion abnormalities in patients with coronary artery disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Review of antiplatelet therapy in secondary prevention of cerebrovascular events: a need for direct comparisons between antiplatelet agents.

Author: JamiesonDara G, ParekhAmit, EzekowitzMichael D

Stroke prevention
Bleeding episodes

This review compares the efficacy of various antiplatelet agents for preventing recurrent strokes, including aspirin, ticlopidine, clopidogrel, extended-release dipyridamole, and triflusal.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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