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An induction dose of epoetin alpha of 40 000 IU daily for three consecutive days increases and maintains hemoglobin levels in anemic cancer patients undergoing chemotherapy.

Author: CeccheriniR, DellachC, FoladoreS, LeitaM, MilaniS, MustacchiG, SistoM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This pilot study evaluated the feasibility, activity, and safety of an induction dose of epoetin alpha in cancer patients with moderate or severe anemia receiving chemotherapy. The results showed that a higher initial dosing of epoetin alpha led to a higher response rate (77%) compared to standard doses, with a mean hemoglobin increase of 2.0 g/dl. The study also found that the treatment was well tolerated and no serious adverse events were observed.
Paper Details　
Original Abstract of the Article :
BACKGROUND: This pilot study was conducted to evaluate the feasibility, activity, and safety of an induction dose of epoetin alpha in cancer patients with moderate or severe anemia who were receiving chemotherapy. PATIENTS AND METHODS: Thirty patients with solid tumors and hemoglobin (Hb) levels <1...See full text at original site
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引用元：
https://doi.org/10.1093/annonc/mdl297

データ提供：米国国立医学図書館（NLM）

Epoetin Alpha: A Refreshing Oasis in the Desert of Anemia

Anemia, a common complication of cancer chemotherapy, can significantly impact a patient’s strength and overall well-being. This study explores the potential of epoetin alpha, a synthetic hormone that stimulates red blood cell production, to alleviate anemia in cancer patients undergoing chemotherapy. Researchers investigated the effects of an induction dose of epoetin alpha (40,000 IU daily for three consecutive days) on hemoglobin levels and the overall management of anemia in these patients. The results revealed that this higher initial dosing of epoetin alpha led to a significant increase in hemoglobin levels and a reduction in the need for blood transfusions, suggesting that it could be a more efficient and effective treatment strategy for chemotherapy-induced anemia.

A Higher Dose, A Higher Response: Finding the Right Dose in the Desert of Anemia

The study highlights the importance of optimizing epoetin alpha dosage to achieve the best possible outcomes in cancer patients with anemia. The findings suggest that a higher initial dose can significantly improve response rates and reduce the need for blood transfusions. This approach could contribute to better overall management of anemia and potentially improve the quality of life for these patients.

Navigating Anemia: A Desert Journey with a New Tool

The study provides valuable insights into the management of anemia in cancer patients. It demonstrates that optimizing epoetin alpha dosage can lead to more effective treatment outcomes. This information empowers both patients and healthcare providers to navigate the desert of anemia with a more effective and patient-centered approach.

Dr.Camel's Conclusion

This study underscores the potential of a higher initial dosing of epoetin alpha for the effective management of anemia in cancer patients undergoing chemotherapy. The findings suggest that this approach could lead to improved response rates and reduced transfusion requirements. As a desert traveler, I know that finding the right resources and strategies is essential for successfully navigating the challenges ahead.

Date :
  1. Date Completed 2007-02-01
  2. Date Revised 2020-02-03
Further Info :

Pubmed ID

16980603

DOI: Digital Object Identifier

10.1093/annonc/mdl297

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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