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In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression.

Author: Barba-BarajasM, Bravo CuellarA, Del Toro-ArreolaS, Delgado-RizoV, Domínguez-RodríguezJ R, Gómez-ContrerasP C, Hernández-FloresG, Lerma-DíazJ M, Ortiz-LazarenoP C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates whether pentoxifylline (PTX) enhances the antitumor effects of perillyl alcohol (P-OH) in human myelomonocytic leukemia cells. Both P-OH and PTX have demonstrated antitumor activity in previous studies, and this research aims to determine if their combined effect is greater than their individual effects.
Paper Details　
Original Abstract of the Article :
Chemotherapy is effective against a wide variety of tumor cells, although its use is limited by side effects. In vitro experiments and phase I and II trials have shown that phytochemicals such as perillyl alcohol (P-OH) have antitumor effects. Pentoxifylline (PTX), a synthetic methylxanthine used ma...See full text at original site
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引用元：
https://doi.org/10.1159/000096003

データ提供：米国国立医学図書館（NLM）

Perillyl Alcohol: A Potential Oasis in the Desert of Leukemia

Leukemia, a formidable disease in the desert of cancer, presents significant challenges for treatment. This research explores the potential of perillyl alcohol (P-OH), a phytochemical with antitumor properties, in combating leukemia. The study investigated the effects of P-OH, alone and in combination with pentoxifylline (PTX), on U937 human myelomonocytic leukemia cells. The findings suggest that PTX may enhance the antitumor effects of P-OH, potentially offering a more effective treatment strategy for this challenging disease.

Hope for Leukemia: Finding an Oasis in the Desert

The study's findings provide a ray of hope in the vast desert of leukemia. The potential for P-OH, combined with PTX, to effectively target leukemia cells offers a promising avenue for treatment. It's like discovering a hidden oasis in a barren landscape, providing potential relief and sustenance.

Navigating the Desert of Leukemia with New Tools

For patients with leukemia, this research offers valuable insights into potential treatment options. It's crucial to consult with a healthcare professional to discuss individualized treatment plans, taking into account the patient's specific situation and potential benefits and risks of various approaches. Remember, navigating the desert of leukemia requires a strong support system, including healthcare providers, loved ones, and research breakthroughs.

Dr. Camel's Conclusion

This research, like a caravan of scientists traversing the desert of leukemia, presents a promising new approach to fighting this devastating disease. The study underscores the importance of exploring natural compounds and combination therapies in the pursuit of effective cancer treatments.

Date :
  1. Date Completed 2007-02-13
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

17008791

DOI: Digital Object Identifier

10.1159/000096003

Related Literature

Article Analysis
・Side Effects of pentoxifylline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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