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Protection of azidothymidine-induced cardiopathology in mice by mildronate, a mitochondria-targeted drug.

Author: GordjushinaValentina, IsajevsSergejs, KalvinshIvars, KlusaVija, KratovskaAina, PupureJolanta, RumaksJuris, SvirskisSimons, TaivansImmanuels, ViksnaLudmila

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mildronate, a cardioprotective drug, was found to effectively protect against azidothymidine-induced cardiopathology in mice. It prevented degeneration and inflammation of cardiac tissue and reduced the expression of nuclear factor kappaBp65 (NF-kappaBp65).
Paper Details　
Original Abstract of the Article :
Azidothymidine, a nucleoside-analogue reverse transcriptase inhibitor (NRTI), is a commonly used antiretroviral drug in AIDS treatment, however its use is limited by severe toxic side effects due to its influence on mitochondria that result in myopathy, particularly affecting the cardiac muscle. We ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1742-7843.2006.pto_543.x

データ提供：米国国立医学図書館（NLM）

Protecting the Heart: Mildronate's Potential in Combating Azidothymidine-Induced Cardiopathology

The field of [HIV/AIDS Treatment] faces a critical challenge in managing the [Cardiotoxic Side Effects] of [Azidothymidine], a widely used [Antiretroviral Drug]. This study explores the potential of [Mildronate], a [Mitochondria-Targeted Drug], in mitigating these adverse effects. The researchers investigated the impact of [Mildronate] on [Cardiopathology] induced by [Azidothymidine] in a mouse model. Their findings reveal that [Mildronate] effectively prevented [Morphological Changes] in cardiac tissue, including [Degeneration] and [Inflammation], induced by [Azidothymidine]. This suggests that [Mildronate] could offer a promising therapeutic strategy for protecting against [Azidothymidine]-induced [Cardiotoxicity].

The Promise of Mildronate in Mitigating Cardiotoxicity

The study's results demonstrate the potential of [Mildronate] in safeguarding the heart against [Azidothymidine]-induced damage. The ability of [Mildronate] to prevent [Morphological Changes] in cardiac tissue suggests its effectiveness in combating [Cardiotoxicity]. This discovery has significant implications for [HIV/AIDS Treatment] by potentially minimizing the risk of [Cardiovascular Complications] associated with [Azidothymidine] therapy.

A New Avenue for Protecting the Heart

This research highlights the importance of considering [Mitochondria-Targeted Drugs] as potential solutions for managing [Cardiotoxicity] in [HIV/AIDS Treatment]. The study's findings offer a promising avenue for exploring the use of [Mildronate] in combination with [Azidothymidine] or other [Anti-HIV Drugs], potentially improving the safety profile of [Antiretroviral Therapy] and enhancing the long-term health of individuals living with HIV.

Dr.Camel's Conclusion

This research is a testament to the power of [Mitochondria-Targeted Drugs] in safeguarding the heart. It underscores the importance of continuing research in this area to develop safer and more effective treatment strategies for [HIV/AIDS]. Like a desert oasis, [Mildronate] offers a glimmer of hope in mitigating the [Cardiotoxic] effects of [Azidothymidine], potentially improving the quality of life for individuals living with HIV.

Date :
  1. Date Completed 2007-02-15
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

17040219

DOI: Digital Object Identifier

10.1111/j.1742-7843.2006.pto_543.x

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English

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