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Chemotherapy for stage IV non-small cell lung cancer.

Author: BitranJ D, VokesE E

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

While chemotherapy regimens for non-small cell lung cancer (NSCLC) have shown modest improvements in survival, particularly in a large randomized trial, toxicity remains a concern, especially for patients with poor health at diagnosis. Further research is needed to identify more effective chemotherapy regimens for NSCLC. Chemotherapy is recommended for selected stage IV patients with good health in clinical trials or to manage symptoms and potentially improve survival in carefully chosen cases outside of a trial setting.
Paper Details　
Original Abstract of the Article :
Chemotherapy regimens with consistent activities in NSCLC have been identified. A modest but statistically significant increase in survival has been shown in a single large randomized trial, with three smaller trials showing either similar results or a trend toward an improved survival. However, che...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1704879

データ提供：米国国立医学図書館（NLM）

Exploring Effective Therapies for Advanced Lung Cancer

The field of oncology is constantly seeking better treatment options for patients with advanced non-small cell lung cancer (NSCLC). This research delves into the effectiveness of chemotherapy regimens in this context. The authors employed a rigorous approach by analyzing data from multiple clinical trials, comparing the outcomes of different chemotherapy regimens. The findings point toward a modest but statistically significant increase in survival for patients receiving chemotherapy, particularly in those with good performance status. This study highlights the importance of continued research in this area to identify even more effective treatments, while acknowledging the challenges posed by chemotherapy-related toxicity.

The Promise and Limitations of Chemotherapy

The research reveals that chemotherapy can offer a lifeline for patients with advanced NSCLC, extending their survival, especially when combined with good performance status. However, the study also cautions that chemotherapy can be accompanied by significant toxicity, impacting the quality of life for patients.

Navigating the Landscape of Lung Cancer Treatment

This study underscores the importance of personalized medicine in cancer treatment. Patients with advanced NSCLC should be carefully evaluated for their individual circumstances, taking into account their performance status and potential for tolerance to chemotherapy. This research serves as a reminder that while chemotherapy can offer valuable benefits, its use must be carefully considered and managed to maximize patient outcomes.

Dr.Camel's Conclusion

Just like a camel navigating the vast desert, patients with advanced lung cancer need a careful and strategic approach to treatment. This research provides valuable insights into the effectiveness of chemotherapy, but underscores the need for continuous research to develop more effective and less toxic therapies.

Date :
  1. Date Completed 1991-03-26
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1704879

DOI: Digital Object Identifier

1704879

Related Literature

Article Analysis
・Effective treatment of lung cancer
SNS
PICO Info
in preparation
Languages

English

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