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Haloperidol versus placebo for schizophrenia.

Author: AdamsC E, JoyC B, LawrieS M

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This review of 21 randomized controlled trials comparing haloperidol with placebo for schizophrenia found that haloperidol was more effective at improving symptoms in the short term, but it also had a higher propensity to cause adverse effects, including movement disorders like dystonia, akathisia, and parkinsonism. The review concluded that haloperidol is a potent antipsychotic drug, but clinicians may wish to prescribe an alternative antipsychotic with less likelihood of adverse effects when a choice is available.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Haloperidol was developed in the late 1950s for use in the field of anaesthesia. Research subsequently demonstrated effects on hallucinations, delusions, aggressiveness, impulsiveness and states of excitement and led to the introduction of haloperidol as an antipsychotic. OBJECTIVES: To...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD003082.pub2

データ提供：米国国立医学図書館（NLM）

Haloperidol: A Potent Antipsychotic with a Side of Side Effects

The world of psychiatry is constantly seeking better ways to manage conditions like schizophrenia. This study dives into the effectiveness and safety of haloperidol, a drug used to treat this serious mental illness. The research compared haloperidol to a placebo, looking at its impact on symptoms and the occurrence of side effects.

Haloperidol Shows Promise, But Watch Out for Side Effects

Haloperidol showed positive results in the initial phase of the study. It improved symptoms in individuals with schizophrenia, but it's important to note that a significant number of people dropped out of the study, indicating potential difficulties with tolerating the medication.

Navigating the Side Effects: A Balancing Act

While haloperidol can be effective in managing schizophrenia, it comes with a price. The study revealed a significant increase in movement disorders, including dystonia, akathisia, and parkinsonism, in patients taking haloperidol. This highlights the importance of careful consideration and monitoring when using this drug.

Dr.Camel's Conclusion

Haloperidol is a powerful antipsychotic, but its effectiveness is overshadowed by the potential for severe side effects. It's like a camel carrying a precious load across the desert - it can reach its destination, but it's a long and bumpy ride. If other treatment options exist, those may be better suited for those with schizophrenia. Ultimately, the decision to use haloperidol must be made on a case-by-case basis, carefully weighing the potential benefits against the risks.

Date :
  1. Date Completed 2007-01-19
  2. Date Revised 2020-05-11
Further Info :

Pubmed ID

17054159

DOI: Digital Object Identifier

10.1002/14651858.CD003082.pub2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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