A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects.

Author: MeltzerHerbert Y, PurdonScot E, WoodwardNeil D, ZaldDavid H

Paper Details 
Original Abstract of the Article :
Prospective, double-blind, randomized trials comparing atypical antipsychotic drugs (APDs) to typical APDs, such as haloperidol, indicate that atypical APDs provide a modest benefit to cognitive function in schizophrenia. However, the validity of this inference has been contested by suggestions that...See full text at original site
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引用元:
https://doi.org/10.1016/j.schres.2006.08.021

データ提供:米国国立医学図書館(NLM)

Haloperidol and Cognitive Function: A Meta-Analysis of Clinical Trials

Haloperidol is a typical antipsychotic medication used to treat conditions such as schizophrenia. This meta-analysis examines the effects of haloperidol on cognitive function in clinical trials comparing typical and atypical antipsychotics. The study investigates the potential impact of haloperidol dosage and practice effects on cognitive performance.

Haloperidol's Effect on Cognition: A Complex Relationship

The meta-analysis found that haloperidol generally improves overall cognitive performance, with no significant difference in effect size between low and high doses. However, doses greater than 24 mg appear to have deleterious effects. The study also found that practice effects, rather than haloperidol's direct effects, may contribute to the observed improvements in some cognitive domains.

Understanding the Nuances of Haloperidol's Impact on Cognition

This meta-analysis provides a comprehensive overview of the effects of haloperidol on cognition. It emphasizes the importance of considering individual patient factors, including dosage and the potential for practice effects, when evaluating the cognitive impact of haloperidol. This knowledge can help clinicians optimize treatment strategies and minimize potential cognitive side effects in individuals receiving haloperidol.

Dr. Camel's Conclusion

Just as a camel navigates the desert, adjusting its stride based on the terrain, healthcare professionals must adapt their approach to managing cognitive function in individuals receiving haloperidol. This meta-analysis provides valuable insights into the complex relationship between haloperidol, dosage, and cognitive performance, highlighting the importance of personalized care and continued research in this area.

Date :
  1. Date Completed 2007-04-03
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

17059880

DOI: Digital Object Identifier

10.1016/j.schres.2006.08.021

SNS
PICO Info
in preparation
Languages

English

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