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Mechanisms involved in the effects of phenidone, diclofenac and ethacrynic acid in rat uterus in vitro.

Author: CantabranaB, HidalgoA, Pérez VallinaJ R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Phenidone, sodium diclofenac, and ethacrynic acid are three drugs that have been proposed as inhibitors of eicosanoid synthesis. In a study of rat uteri, all three drugs inhibited the contractions induced by oxytocin, methacholine, prostaglandin F2a, and CaCl2.
Paper Details　
Original Abstract of the Article :
1. The effects of phenidone (P, 10(-4)-10(-3) M), sodium diclofenac (D, 10(-5)-10(-4) M) and ethacrynic acid (E, 10(-5)-10(-4) M), proposed as inhibitors of eicosanoid synthesis, on the contractions of rat uterus induced by several agonists have been studied. 2. P, D and E inhibit the motility induc...See full text at original site
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引用元：
https://doi.org/10.1016/0306-3623(91)90003-o

データ提供：米国国立医学図書館（NLM）

Exploring the Effects of Phenidone, Diclofenac, and Ethacrynic Acid on the Rat Uterus

This research delves into the intricate world of uterine contractions, exploring the effects of three compounds – phenidone, diclofenac, and ethacrynic acid – on rat uterus in vitro. The study investigates their potential to inhibit eicosanoid synthesis, a crucial process involved in regulating uterine contractions. Researchers found that all three compounds significantly inhibited contractions induced by various agonists, including oxytocin, methacholine, prostaglandin F2a, and CaCl2. These findings shed light on the potential therapeutic implications of these compounds in managing uterine activity.

Potential for Therapeutic Applications in Uterine Function

The study's results suggest that phenidone, diclofenac, and ethacrynic acid could have therapeutic applications in regulating uterine function. Their ability to inhibit contractions induced by various agonists opens up possibilities for developing new treatments for conditions involving abnormal uterine activity, such as dysmenorrhea or preterm labor.

Camel's Perspective: A Desert Oasis for Uterine Function

Imagine a camel crossing a barren desert, seeking a refreshing oasis. These compounds, like cool springs in the desert, offer a potential way to regulate uterine activity, providing a much-needed respite for those experiencing challenges with their reproductive health.

Dr.Camel's Conclusion

This research provides valuable insights into the effects of phenidone, diclofenac, and ethacrynic acid on uterine contractions. The study's findings suggest that these compounds could have therapeutic potential in managing conditions involving abnormal uterine activity. Further research is warranted to explore the specific applications and optimal dosages of these compounds in treating various uterine-related conditions.

Date :
  1. Date Completed 1991-09-17
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

1714410

DOI: Digital Object Identifier

10.1016/0306-3623(91)90003-o

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Languages

English

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