Constant mitochondrial DNA levels in blood leukocytes of patients enrolled in a NRTI-free therapeutic trial (BIKS-2 study).

Author: AllavenaC, AmellalB, André-GarnierE, BonmarchandM, CalvezV, DelfraissyJ F, FerréV, LafeuilladeA, RaffiF, ValantinM A

Paper Details 
Original Abstract of the Article :
OBJECTIVES: Determine if a nucleoside reverse transcriptase inhibitors (NRTI)-free regimen affected mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells (PBMCs) of patients enrolled in BIKS-2 trial. METHODS: Antiretroviral (ARV) naïve (N=13) and NRTI experienced (N=7) patients, re...See full text at original site
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引用元:
https://doi.org/10.1016/j.jinf.2006.11.009

データ提供:米国国立医学図書館(NLM)

Mitochondrial DNA in HIV Treatment: Maintaining a Desert Oasis

Mitochondrial DNA (mtDNA) is crucial for cellular energy production, like a desert oasis providing sustenance for life. This research investigates the impact of a nucleoside reverse transcriptase inhibitors (NRTI)-free regimen on mtDNA levels in patients with HIV. The researchers enrolled patients in the BIKS-2 trial, which aimed to assess the long-term effects of a specific antiretroviral regimen.

Preserving the Desert Oasis

The study found that the NRTI-free regimen did not affect mtDNA levels in the patients participating in the BIKS-2 trial. This finding is like ensuring the preservation of a vital oasis in a harsh desert environment.

Navigating the Desert of HIV Treatment

This research provides valuable insights into the long-term effects of antiretroviral therapy on mtDNA levels in HIV-infected individuals. Like a camel traversing a desert, it is essential to find treatment strategies that minimize potential side effects and maintain overall health.

Dr. Camel's Conclusion

This research highlights the importance of considering the impact of antiretroviral therapy on mitochondrial DNA levels in HIV-infected individuals. Like a camel seeking a sustainable source of water in a desert, finding treatment regimens that preserve mitochondrial function is crucial for long-term health. Remember, like a desert oasis, mitochondrial health is a vital resource that requires careful management.

Date :
  1. Date Completed 2007-05-31
  2. Date Revised 2007-12-14
Further Info :

Pubmed ID

17207857

DOI: Digital Object Identifier

10.1016/j.jinf.2006.11.009

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