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Danazol for unexplained subfertility.

Author: BrownJ, HughesE, TiffinG, VandekerckhoveP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review assessed the effect of danazol on live birth rate in women with unexplained subfertility. The review found no evidence of the benefit of danazol for unexplained subfertility. Although there is insufficient evidence to be certain, the need for contraception during treatment and the adverse effects and costs of danazol make its use for this problem unwarranted.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The synthetic androgen Danazol, was developed in the 1970's as a treatment for endometriosis. Its use was soon advocated in women with unexplained subfertility. Two randomised trials were subsequently conducted to assess the effectiveness of danazol in this population. OBJECTIVES: The o...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD000069.pub2

データ提供：米国国立医学図書館（NLM）

Danazol for Unexplained Subfertility: A Critical Look

This research delves into the effectiveness of danazol, a synthetic androgen, as a treatment for unexplained subfertility. The study examines the results of two randomized trials, comparing danazol to placebo or no treatment in women with unexplained subfertility. The authors meticulously analyze the data, seeking to determine whether danazol offers a viable solution for couples struggling to conceive.

Limited Evidence of Danazol's Effectiveness

The findings of this review present a sobering conclusion: there is no significant evidence to support the use of danazol for unexplained subfertility. The study found no statistically significant difference in live birth rates between danazol and placebo groups. Furthermore, the review highlights the potential side effects associated with danazol, emphasizing the need for contraception during treatment and weighing the risks against the limited potential benefits.

Addressing Subfertility: A Multifaceted Approach

This research underscores the complex nature of subfertility and the need for careful consideration of treatment options. While danazol has not proven to be an effective treatment for unexplained subfertility, there are other potential avenues for couples seeking to conceive. It is crucial to consult with healthcare professionals to explore a personalized approach that considers individual circumstances and medical history.

Dr.Camel's Conclusion

Imagine the journey of a couple seeking to conceive as a long trek through the desert of infertility. Just as a camel needs a steady supply of water to thrive, so too do couples need a reliable source of support and guidance. While danazol may not be the oasis they seek, there are other pathways to explore and resources to utilize.
Date :
  1. Date Completed 2007-05-08
  2. Date Revised 2018-12-21
Further Info :

Pubmed ID

17253444

DOI: Digital Object Identifier

10.1002/14651858.CD000069.pub2

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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