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Lack of indinavir-associated nephrological complications in HIV-infected adults (predominantly women) with high indinavir plasma concentration in Abidjan, Côte d'Ivoire.
Author: AnglaretXavier, AnzianAmani, BissagneneEmmanuel, DanelChristine, GabillardDelphine, GomisOlivier Ba, MingaAlbert, MohRaoul, NzunettuGustave, PeytavinGilles, SalamonRoger, SeriBoga
Original Abstract of the Article :
To report the tolerance of indinavir combined with ritonavir (IDV/r 800/100 mg) twice daily (bid) in sub-Saharan African HIV-infected adults. HAART-naives patients started zidovudine plus lamivudine plus IDV/r 800/100 mg bid. Follow-up included standardized documentation of morbidity, CD4(+) cell co...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/17263634
データ提供:米国国立医学図書館(NLM)
Indinavir's Impact on HIV-Infected Adults in Abidjan
The realm of HIV/AIDS research is an arid desert of challenges, where scientists constantly search for oases of effective treatment. This study investigates the efficacy and tolerability of indinavir, a potent antiretroviral drug, in a group of HIV-infected adults in Abidjan, Côte d'Ivoire. The researchers employed a prospective observational design to assess the impact of indinavir, combined with ritonavir, on the patients' health outcomes. The study revealed that indinavir led to significant reductions in viral load and improvements in CD4 cell counts, a positive sign in the fight against HIV infection. However, the study also observed a high incidence of digestive intolerance, highlighting the importance of individualized therapy for managing side effects.
The Mystery of Indinavir Tolerance in Sub-Saharan Africa
The study revealed a surprising lack of nephrological side effects, which is particularly interesting. This suggests that indinavir might be better tolerated by individuals in sub-Saharan Africa than in Americans or Europeans. This intriguing observation deserves further exploration, as it could potentially inform future HIV treatment strategies.
Navigating the Desert of HIV Treatment
This research underscores the importance of tailored treatment approaches, considering the unique characteristics of different patient populations. The study's findings serve as a valuable reminder that while we strive to conquer the vast desert of HIV infection, we must be prepared for the unexpected and navigate with caution, always seeking the most effective path for each individual.
Dr.Camel's Conclusion
This study sheds light on the complex landscape of HIV treatment. While indinavir offers hope for many, we must remember that each patient is unique. We must approach treatment with care, recognizing the importance of individualized therapy and understanding the nuances of drug response in diverse populations. It is important to embrace the desert of unknowns and continue our journey towards finding even more effective and tolerable therapies for all individuals.
Date :
- Date Completed 2007-04-11
- Date Revised 2018-11-13
Further Info :
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