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A multicenter, open comparative study of parenteral cefotaxime and ceftriaxone in the treatment of nosocomial lower respiratory tract infections.

Author: AugerP, ChanR M, ConlyJ M, GarberG E, GersonM, ShafranS D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Low-dose cefotaxime was found to be as effective as ceftriaxone in treating nosocomial pneumonia. In a preliminary report of 57 patients, 93% responded to therapy in both groups. However, ceftriaxone was associated with more side effects (14.2%).
Paper Details　
Original Abstract of the Article :
A multicenter Canadian study enrolled 74 persons to compare low-dose cefotaxime at 1 g every 8 hr to ceftriaxone 1 g every 12 hr in patients with nosocomial pneumonia. Of 57 evaluable patients (30 cefotaxime and 27 ceftriaxone) in this preliminary report, 93% responded to therapy in both groups. Cef...See full text at original site
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引用元：
https://doi.org/10.1016/0732-8893(92)90061-w

データ提供：米国国立医学図書館（NLM）

Cefotaxime vs. Ceftriaxone: A Comparative Study for Nosocomial Lower Respiratory Tract Infections

Nosocomial pneumonia, an infection acquired in a hospital setting, can be challenging to treat. Imagine a desert traveler encountering a sudden sandstorm, requiring a timely and effective intervention. This multicenter study compares the effectiveness of two antibiotics, cefotaxime and ceftriaxone, in treating nosocomial lower respiratory tract infections.

Cefotaxime: A Viable Option for Nosocomial Pneumonia

The researchers found that both cefotaxime and ceftriaxone were effective in treating nosocomial pneumonia. However, cefotaxime was associated with fewer side effects than ceftriaxone, making it a potentially more favorable option. It's like discovering two different oases in the desert, both offering respite from the heat, but one offering a more comfortable and refreshing experience.

Navigating the Desert of Infection: Choosing the Right Antibiotic

This study provides valuable information for healthcare professionals treating nosocomial pneumonia. While both cefotaxime and ceftriaxone are effective, cefotaxime's lower incidence of side effects suggests it could be a preferred choice in some cases. It's essential to consult with a healthcare professional to determine the most appropriate antibiotic for your specific needs.

Dr.Camel's Conclusion

This study suggests that cefotaxime could be a viable alternative to ceftriaxone in the treatment of nosocomial lower respiratory tract infections. Its lower incidence of side effects makes it a potentially more favorable option, particularly for patients seeking a less burdensome treatment regimen.

Date :
  1. Date Completed 1992-02-19
  2. Date Revised 2019-09-02
Further Info :

Pubmed ID

1730189

DOI: Digital Object Identifier

10.1016/0732-8893(92)90061-w

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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