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Licofelone--a novel analgesic and anti-inflammatory agent.

Author: KulkarniS K, SinghVijay Pal

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Licofelone, a dual COX/LOX inhibitor, possesses analgesic, anti-inflammatory, and antiasthmatic effects without causing gastrointestinal side effects. Preclinical studies show its effectiveness in various animal models, suggesting its potential for treating osteoarthritis and other inflammatory conditions.
Paper Details　
Original Abstract of the Article :
Dual inhibitors that block both cyclooxygenase (COX) and lipoxygenase (LOX) metabolic pathways of arachidonic acid are expected to possess clinical advantages over the selective inhibitors of COX enzyme. One of the most promising compounds belonging to this category is licofelone ([2,2 -dimethyl -6-...See full text at original site
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引用元：
https://doi.org/10.2174/156802607779941305

データ提供：米国国立医学図書館（NLM）

Licofelone: A New Oasis in the Desert of Pain

Pain management research continuously seeks novel and effective analgesics with fewer side effects. This review examines the pharmacological profile of licofelone, a dual inhibitor of both cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism. The authors highlight the potential advantages of dual inhibitors over selective COX inhibitors, particularly in terms of reducing gastrointestinal (GI) side effects. Preclinical studies have demonstrated licofelone’s analgesic, anti-inflammatory, and antiasthmatic effects in various animal models, with a favorable safety profile.

A New Path in the Sands: Dual Inhibition for Pain Relief

The study's exploration of licofelone's potential as a dual inhibitor opens up new possibilities for pain management.

Navigating the Desert of Pain

As a pain management specialist, I am constantly searching for safe and effective treatments for my patients. This review highlights the potential of licofelone as a dual inhibitor, offering a promising new avenue for pain management with a potentially reduced risk of GI side effects.

Dr. Camel's Conclusion

This review examines the pharmacological profile of licofelone, a dual inhibitor of both cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism. The authors highlight the potential advantages of dual inhibitors over selective COX inhibitors, particularly in terms of reducing gastrointestinal (GI) side effects. Preclinical studies have demonstrated licofelone’s analgesic, anti-inflammatory, and antiasthmatic effects in various animal models, with a favorable safety profile.

Date :
  1. Date Completed 2007-03-26
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

17305568

DOI: Digital Object Identifier

10.2174/156802607779941305

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Languages

English

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