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Effects of bicistronic lentiviral vector-mediated herpes simplex virus thymidine kinase/ganciclovir system on human lens epithelial cells.

Author: LiuTian Jin, LuYi, YangJin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lentivirus-mediated suicide gene therapy might be a feasible treatment strategy to prevent capsule opacification by killing lens epithelial cells.
Paper Details　
Original Abstract of the Article :
Posterior capsule opacification (PCO) is the most common complication after phacoemulsification cataract surgery. Hyperplasia of the lens epithelial cell after phacoemulsification is thought to be an important feature contributing to PCO. In this study,we investigated the feasibility of killing the ...See full text at original site
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引用元：
https://doi.org/10.1080/02713680601112793

データ提供：米国国立医学図書館（NLM）

Gene Therapy for Posterior Capsule Opacification: A Camel's Journey to Clear Vision

Posterior capsule opacification (PCO) is a common complication after cataract surgery, leaving patients with blurry vision. This study investigated the feasibility of using lentiviral vectors to deliver a suicide gene therapy system, targeting lens epithelial cells, to prevent PCO.

Gene Therapy for PCO: A New Approach to Vision Preservation

The researchers successfully delivered a lentiviral vector expressing the herpes simplex virus thymidine kinase (HSV-tk) gene into human lens epithelial cells (HLECs). When treated with ganciclovir, the infected HLECs underwent apoptosis, demonstrating the potential of this gene therapy system to prevent PCO.

Gene Therapy: A Camel's Perspective on Restoring Vision

This research presents a promising new approach to preventing PCO, a common complication following cataract surgery. By using lentiviral vectors to deliver a suicide gene therapy system, researchers aim to target and eliminate lens epithelial cells, preventing cloudiness of the lens capsule and preserving vision.

Dr. Camel's Conclusion

This study demonstrates the potential of lentiviral vector-mediated gene therapy for preventing PCO. The researchers successfully delivered the HSV-tk gene into HLECs, demonstrating the effectiveness of this approach in inducing apoptosis and preventing PCO. Further research is needed to optimize the delivery system and assess its long-term safety and efficacy in human patients.
Date :
  1. Date Completed 2007-03-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17364733

DOI: Digital Object Identifier

10.1080/02713680601112793

Related Literature

Article Analysis
・Effects of ganciclovir
SNS
PICO Info
in preparation
Languages

English

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