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Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects.

Author: BrandtJohn T, FaridNagy A, JakubowskiJoseph A, LachnoD Richard, LiYing G, NaganumaHideo, PayneChristopher D, WeerakkodyGovinda J, WintersKenneth J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the interaction of prasugrel, an orally active antiplatelet agent, with aspirin in healthy subjects. Prasugrel, dosed as LD followed by MD in the presence of ASA, was well tolerated and provided greater platelet inhibition than ASA alone.
Paper Details　
Original Abstract of the Article :
The aims of this open-label, randomized, dose-escalation pharmacodynamic study of prasugrel, an orally active antiplatelet agent, were to assess its interaction with aspirin (ASA, 325 mg) in healthy subjects after a loading dose (LD) and subsequent 5 days of once-daily maintenance doses (MD) of pras...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17414229

データ提供：米国国立医学図書館（NLM）

Prasugrel and Aspirin: A Powerful Antiplatelet Duo

This research explores the fascinating world of antiplatelet therapy, investigating the synergistic effects of prasugrel and aspirin in preventing blood clots. It's like embarking on a journey through the desert of cardiovascular health, seeking to understand the intricate mechanisms that regulate blood clotting.

The study found that prasugrel, an oral antiplatelet agent, exhibits dose-dependent inhibition of platelet aggregation, providing greater platelet inhibition than aspirin alone. When combined with aspirin, prasugrel demonstrated additive inhibition of platelet aggregation, creating a powerful antiplatelet duo. It's like finding a hidden oasis of synergistic efficacy in the desert of antiplatelet therapy, offering a more effective approach to preventing cardiovascular events.

Prasugrel and Aspirin: A Powerful Combination for Cardiovascular Health

This study provides compelling evidence for the effectiveness of prasugrel and aspirin in preventing platelet aggregation. It's like discovering a hidden wellspring of protection in the desert of cardiovascular disease, offering a potent combination to reduce the risk of heart attacks and strokes.

Implications for Health and Lifestyle

This research underscores the importance of effective antiplatelet therapy in preventing cardiovascular events. It's like finding a hidden trail through the desert of heart health, leading to more effective strategies for reducing the risk of heart attacks and strokes. This study highlights the importance of consulting with a healthcare professional to determine the most appropriate antiplatelet therapy for individual needs.

Dr.Camel's Conclusion

This study is a reminder that even in the vast and seemingly well-mapped desert of cardiovascular research, there are still many hidden oases of innovation waiting to be discovered. We must continue to explore these mysteries with patience and an open mind, for each new finding can illuminate a path towards better health and well-being.

Date :
  1. Date Completed 2007-05-08
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

17414229

DOI: Digital Object Identifier

00005344-200703000-00008

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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