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Mechanisms of skeletal muscle degradation and its therapy in cancer cachexia.

Author: AdrianT E, DingX-Z, MelstromK A, MelstromL G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This abstract discusses cancer cachexia, a condition characterized by weight loss and muscle wasting, and the role of the ubiquitin-proteasome pathway in its development. It highlights the severity of cachexia in pancreatic cancer and the need for effective treatment strategies.
Paper Details　
Original Abstract of the Article :
Severe or chronic disease can lead to cachexia which involves weight loss and muscle wasting. Cancer cachexia contributes significantly to disease morbidity and mortality. Multiple studies have shown that the metabolic changes that occur with cancer cachexia are unique compared to that of starvation...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://doi.org/10.14670/HH-22.805

データ提供：米国国立医学図書館（NLM）

Cancer Cachexia: Understanding Muscle Degradation and Therapeutic Approaches

Cancer cachexia, a complex syndrome characterized by [weight loss and muscle wasting], significantly contributes to [morbidity and mortality] in cancer patients. This review explores the [mechanisms of skeletal muscle degradation] in cancer cachexia and discusses current therapeutic approaches for managing this debilitating condition.

The Complexities of Cancer Cachexia: Unveiling the Mechanisms of Muscle Wasting

The review highlights the [ubiquitin (Ub)-proteasome pathway] as a key player in muscle protein degradation in cancer cachexia. This pathway is stimulated by various [cytokines], such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, interferon-gamma, and proteolysis-inducing factor, which are often elevated in cancer patients. The review also discusses the role of [lysosomal system and cytosolic proteases] in muscle degradation.

Finding Solutions: Exploring Therapies for Cancer Cachexia

The review examines various therapeutic approaches for managing cancer cachexia, including [nutritional supplementation and pharmacological agents]. While there is no single cure for cancer cachexia, ongoing research focuses on developing strategies to [reduce muscle wasting and improve patient outcomes]. As a wise camel, I always emphasize the importance of a holistic approach to cancer care, addressing not only the tumor but also the systemic effects of the disease.

Dr. Camel's Conclusion

This review explores the intricate mechanisms of muscle degradation in cancer cachexia and examines promising therapeutic approaches. While cancer cachexia remains a complex and challenging condition, ongoing research offers hope for developing effective strategies to improve patient outcomes. As a wise camel, I always emphasize the importance of seeking comprehensive care for cancer, addressing both the tumor and its systemic effects to ensure optimal health and well-being.

Date :
  1. Date Completed 2007-05-17
  2. Date Revised 2017-02-27
Further Info :

Pubmed ID

17455154

DOI: Digital Object Identifier

10.14670/HH-22.805

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Languages

English

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