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Maximizing anticholinergic therapy for overactive bladder: has the ceiling been reached?

Author: MacDiarmidScott A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the use of muscarinic receptor antagonists, including oxybutynin, tolterodine, trospium chloride, darifenacin, and solifenacin, in the treatment of overactive bladder (OAB). While these medications are effective in reducing symptoms, strategies to increase their therapeutic index, such as behavioral therapy, flexible dosing, and novel formulations, are being explored to reduce anticholinergic side effects.
Paper Details　
Original Abstract of the Article :
Urinary incontinence affects an estimated 20-33% of adults the USA and 55% of the country's elderly [1], having a more substantial impact on the physical and mental dimension of quality of life than other common chronic diseases. Muscarinic receptor antagonists, including oxybutynin, tolterodine, tr...See full text at original site
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引用元：
https://doi.org/10.1111/j.1464-410X.2007.06881.x

データ提供：米国国立医学図書館（NLM）

Overactive Bladder: Reaching New Heights in Anticholinergic Therapy

Overactive bladder (OAB), a prevalent condition affecting millions worldwide, presents a significant challenge for healthcare professionals. This study examines the effectiveness of anticholinergic therapy in managing OAB, exploring strategies to maximize its therapeutic benefits and minimize side effects. The authors aim to provide a comprehensive overview of the current state of anticholinergic therapy for OAB, highlighting the latest advancements and future directions for research.

A Journey Through the Sands of Time: The Evolution of Anticholinergic Therapy

The study highlights the continuous evolution of anticholinergic therapy for OAB, drawing parallels to a traveler traversing a vast and ever-changing desert landscape. The authors acknowledge the challenges of managing OAB and underscore the importance of finding effective and well-tolerated treatments. The study examines the effectiveness of various anticholinergic medications, including oxybutynin, tolterodine, trospium chloride, darifenacin, and solifenacin, exploring their individual benefits and drawbacks.

The Quest for Balance: Navigating the Challenges of Anticholinergic Therapy

Anticholinergic therapy offers a valuable tool for managing OAB, but like a traveler navigating a treacherous desert, careful considerations must be made. The study highlights the importance of balancing therapeutic benefits with potential side effects, particularly dry mouth. The authors underscore the role of newer formulations and delivery systems, such as the oxybutynin transdermal patch, in improving the therapeutic index and reducing the incidence of side effects.

Dr. Camel's Conclusion

Overactive bladder, a condition that can disrupt everyday life, demands innovative approaches to treatment. This study provides valuable insights into the evolution of anticholinergic therapy, highlighting the importance of finding effective and well-tolerated solutions. Like a wise desert traveler, we must strive for a balanced approach, embracing the therapeutic potential of anticholinergics while acknowledging the need for careful consideration and ongoing research to minimize potential side effects.
Date :
  1. Date Completed 2007-07-09
  2. Date Revised 2007-05-09
Further Info :

Pubmed ID

17488367

DOI: Digital Object Identifier

10.1111/j.1464-410X.2007.06881.x

SNS
PICO Info
in preparation
Languages

English

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