Side Effects of trospium: A Synthesis of Findings from 30 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of trospium: A Synthesis of Findings from 30 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Key Research Findings

Trospium is a medication used to treat overactive bladder. Research shows that trospium is effective in improving symptoms of overactive bladder and is generally well tolerated. 12

Reasons for Side Effects

Trospium is a type of drug called antimuscarinic agents. Antimuscarinic agents block muscarinic receptors, which are found in various organs, including the bladder, and play a role in controlling bladder contraction. Trospium works by binding to muscarinic receptors, inhibiting bladder contraction, and improving symptoms of overactive bladder. However, trospium can also bind to muscarinic receptors in other organs, which can cause side effects. 15

Common Side Effects

Dry mouth

The most common side effect of trospium is dry mouth. Trospium inhibits saliva secretion by binding to muscarinic receptors in the salivary glands, leading to dry mouth. 12 10

Constipation

Trospium can cause constipation by binding to muscarinic receptors in the intestines, inhibiting intestinal movement. 12

Blurred vision

Trospium can cause blurred vision by binding to muscarinic receptors in the eyes, inhibiting pupillary constriction. 22

Other side effects

In addition to the above side effects, trospium can cause other side effects such as dizziness, headache, fatigue, urinary retention, frequent urination, difficulty urinating. 18

Side Effects Management

Dry mouth

If you are concerned about dry mouth, make sure you drink plenty of fluids. Chewing gum or candy can also be effective. 12

Constipation

If you are concerned about constipation, eat a diet high in fiber. It is also effective to drink plenty of fluids and exercise lightly. 12

Blurred vision

If you are concerned about blurred vision, avoid driving or working with precision equipment. 22

Comparison Between Studies

Commonalities between studies

Many studies have shown that trospium is effective in improving symptoms of overactive bladder. Also, trospium has been shown to be generally well tolerated. 18 12

Differences between studies

Studies on trospium side effects may have different results depending on the study. For example, some studies have suggested that trospium may affect cognitive function. However, other studies have not found evidence that trospium affects cognitive function. 15

Cautions for Real-Life Application

Trospium is effective in improving symptoms of overactive bladder, but it can cause side effects. It is important to discuss the risks and benefits of trospium with your doctor before taking it. 12

Limitations of Current Research

Long-term side effects of trospium have not been sufficiently studied. Further research is also needed on the potential effects of trospium on cognitive function. 30

Directions for Future Research

Further research is needed on the long-term side effects of trospium and its impact on cognitive function. Research on trospium administration methods and dosage is also needed. 30

Conclusion

Trospium is an effective medication for treating overactive bladder, but it can cause side effects. It is important to discuss the risks and benefits of trospium with your doctor before taking it. 12

Keywords
Benefit Keywords
Procognitive activity
Reduced peripheral side effects
1
Improved OAB symptoms
2
Improves bladder function
Treats urinary incontinence
3
Overactive bladder treatment
4
Detrusor overactivity treatment
5
Reduce frequency
Reduce incontinence
Reduce urgency
6
Treats overactive bladder
7
Safe for normal IOP
Symptom relief
8
UUI reduction
Urgency severity reduction
Urinary urgency reduction
Voided volume increase
9
Overactive bladder treatment
10
Overactive bladder treatment
11
Overactive bladder treatment
12
Low side effects
Reduced gastric acid
Reduced gastric motility
14
Overactive bladder treatment
15
Improved adherence
16
IPSS normalization
Urgency reduction
17
OAB treatment
18
Improves bladder function
Reduces incontinence
19
None reported
20
Reduced incontinence episodes
21
Does not cross blood-brain barrier
Minimally metabolised
Overactive bladder treatment
22
Overactive bladder treatment
23
Lower urinary tract symptoms treatment
24
OAB treatment
25
Overactive bladder treatment
26
Improved bladder function
27
Extended release
Local drug delivery
Reduced side effects
Tailored release
28
Improved urinary incontinence
29
Overactive bladder treatment
30
Risk Keywords
Dry mouth
2
Few side effects
3
Blurred vision
CNS side effects
Constipation
Dry mouth
6
Central nervous system disorders
7
Decreased tear secretion
Dry eye
8
Constipation
Dry mouth
9
Dry mouth
10
Constipation
Dry mouth
12
Cognitive impairment
15
Side effects
16
Overactive bladder
Prostate brachytherapy
17
Side effects
18
Mild side effects
19
Economic factors affect compliance
Low compliance
20
Dry mouth
21
Blurred vision
CNS side effects
Constipation
Dry mouth
22
Cognitive impairment
Confusion
Dizziness
23
Adverse drug reactions
24
Cognitive side effects
Mortality risk
25
Anticholinergic side effects
27
Central nervous system effects
30
Literature analysis of 30 papers
Positive Content
27
Neutral Content
2
Negative Content
1
Article Type
5
1
2
11
30
1.

Discovery of Procognitive Antipsychotics by Combining Muscarinic M<sub>1</sub> Receptor Structure-Activity Relationship with Systems Response Profiles in Zebrafish Larvae.

Author: HellmanKarin, OhlssonJörgen, MaloMarcus, OlssonRoger, EkFredrik

Procognitive activity
Reduced peripheral side effects

This study evaluated the antipsychotic and procognitive properties of NDMC analogue 13f in zebrafish. The analogue demonstrated antipsychotic activity similar to clozapine, with M1 agonist activity and reduced peripheral side effects when co-administered with trospium chloride.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effect of trospium chloride on urodynamic parameters in patients with detrusor hyperreflexia due to spinal cord injuries. A multicentre placebo-controlled double-blind trial.

Author: StöhrerM, BauerP, GiannettiB M, RichterR, BurgdörferH, MürtzG

Improves bladder function
Treats urinary incontinence
Few side effects

In a multicenter placebo-controlled double-blind study, 61 patients with spinal cord injuries and detrusor hyperreflexia were treated with trospium chloride (20 mg twice daily) for 3 weeks. The treatment group experienced significant improvements in maximum cystometric capacity, decreased maximum detrusor pressure, and increased compliance, while the placebo group showed no substantial changes. Side effects were extremely low and comparable between the groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

[Long-term safety and efficacy of trospium chloride for the treatment of neurogenic overactive bladder due to Parkinson's disease is there an effect on cognitive status?]

Author: KorshunovaE S, AndreevM N, KorshunovM N, PyatnitskayaT M, KorshunovD M, DarenkovS P, SuponevaN A

Overactive bladder treatment

Trospium chloride was effective in treating neurogenic overactive bladder in patients with Parkinson's disease (PD) and did not affect cognitive functions during long-term use.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

5.

Bioavailability of trospium chloride after intravesical instillation in patients with neurogenic lower urinary tract dysfunction: A pilot study.

Author: WalterP, GrosseJ, BihrA M, KramerG, SchulzH U, SchwantesU, StöhrerM

Detrusor overactivity treatment

Six men with traumatic spinal cord lesions were randomized to intravesical instillation with 15 or 30 mg trospium chloride. Four positive samples were found in three patients. It is concluded that intravesically instilled trospium chloride is not absorbed into the circulation in significant amounts and, thus, it may be expected that this mode of administration will improve the efficacy of trospium chloride therapy by reducing the side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Effect of trospium chloride therapy on intraocular pressure and tear secretion in overactive bladder patients.

Author: TurkogluAli Riza, Parmak YenerNeslihan, CobanSoner, GuzelsoyMuhammet, EmulAli, DemirbasMurat, DemirciHakan

Safe for normal IOP
Symptom relief
Decreased tear secretion
Dry eye

Trospium chloride significantly decreased the symptoms in female patients with overactive bladder (OAB). Although trospium chloride did not cause a significant change in intraocular pressure (IOP) in these patients, it was found to decrease tear secretion significantly.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Trospium 60 mg once daily (QD) for overactive bladder syndrome: results from a placebo-controlled interventional study.

Author: DmochowskiRoger R, SandPeter K, ZinnerNorman R, StaskinDavid R

UUI reduction
Urgency severity reduction
Urinary urgency reduction
Voided volume increase
Constipation
Dry mouth

Trospium chloride once-daily represents a convenient, effective, and well-tolerated treatment option for overactive bladder.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

[Intravesical treatment of overactive bladder syndrome].

Author: HaferkampA, HohenfellnerM

Overactive bladder treatment

Intravesical therapies, including anticholinergics, botulinum toxin, local anesthetics, capsaicin, and resiniferatoxin, are being investigated as alternative treatments for overactive bladder.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

13.

[Neurogenic overactive bladder: focus on cognitive function].

Author: KorshunovaE S, KorshunovM N, NuzhnyiE P, ZakroyshhikovaI V, ZabirovaA Kh, KorshunovD M, NSuponeva A, DarenkovS P

This abstract discusses the common medical and social problems of overactive bladder and cognitive impairment, highlighting the importance of understanding the pathogenesis of underlying diseases and the pharmacologic properties of drugs used in treating these conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

14.

[Inhibition of gastric acid secretion and motility with trospium chloride].

Author: LuxG, FrühmorgenP

Low side effects
Reduced gastric acid
Reduced gastric motility

Trospiumchloride, a new drug, was found to be effective in inhibiting gastric acid secretion and gastric motility without the usual side effects of anticholinergic therapy, such as tachycardia, reduction of salivary secretion, and impairment of visual accommodation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

15.

Antimuscarinic drugs: review of the cognitive impact when used to treat overactive bladder in elderly patients.

Author: PagoriaDustin, O'ConnorR Corey, GuralnickMichael L

Overactive bladder treatment
Cognitive impairment

Antimuscarinics are used to treat overactive bladder (OAB), but some can cause cognitive side effects. Oxybutynin can adversely affect cognition in elderly patients, while darifenacin, trospium, solifenacin, and tolterodine appear to be safe for this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Long-term adherence to antimuscarinic therapy in everyday practice: a systematic review.

Author: VeenboerPaul W, BoschJ L H Ruud

Improved adherence
Side effects

Long-term adherence to antimuscarinic drugs is poor, highlighting the need for strategies to improve patient compliance and persistence with treatment regimens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Role of trospium chloride in brachytherapy-related detrusor overactivity.

Author: BittnerNathan, MerrickGregory S, BrammerSarah, NiehausAngela, WallnerKent E, ButlerWayne M, AllenZachariah A, GalbreathRobert W

IPSS normalization
Urgency reduction
Overactive bladder
Prostate brachytherapy

Nearly 80% of patients with brachytherapy-related detrusor overactivity responded favorably to trospium with improvements in IPSS, especially urgency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Pharmacologic management of overactive bladder.

Author: LamSum, HilasOlga

OAB treatment
Side effects

Overactive bladder (OAB) is a common condition that can affect any age group. Antimuscarinic agents are the mainstay of pharmacologic treatment for OAB. This article summarizes the efficacy, contraindications, precautions, dosing, and common side effects of five antimuscarinic agents approved for OAB treatment in the United States.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

[High-dose trospium chloride in therapy of detrusor hyperreflexia].

Author: MadersbacherH, StöhrerM, RichterR, GiannettiB M, MürtzG

Improves bladder function
Reduces incontinence
Mild side effects

Trospium chloride was effective in improving bladder capacity and compliance, reducing detrusor pressure, and controlling urinary incontinence in patients with reflex bladder due to spinal cord injury.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

21.

[Medical therapy of urinary incontinence].

Author: OelkeM, de la RosetteJ J, MichelM C, JonasU

Reduced incontinence episodes
Dry mouth

Urinary incontinence is a common condition affecting both men and women. This article reviews current treatment options, including duloxetine for stress urinary incontinence and muscarinic receptor antagonists for urge urinary incontinence.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

22.

Trospium chloride: the European experience.

Author: MadersbacherHelmut, RovnerEric

Does not cross blood-brain barrier
Minimally metabolised
Overactive bladder treatment
Blurred vision
CNS side effects
Constipation
Dry mouth

Trospium chloride is a muscarinic receptor antagonist used to treat overactive bladder. It is effective in decreasing symptoms of urgency and urgency incontinence, but can have side effects like dry mouth and blurred vision.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Systematic review and meta-analysis: do clinical trials testing antimuscarinic agents for overactive bladder adequately measure central nervous system adverse events?

Author: PaquetteAmélie, GouPauline, TannenbaumCara

Overactive bladder treatment
Cognitive impairment
Confusion
Dizziness

Antimuscarinic drugs are used to treat overactive bladder. While studies in healthy volunteers suggest that these drugs may cause cognitive impairment, clinical trials in patients with overactive bladder only report rare central nervous system (CNS) side effects. This discrepancy may be explained by a lack of systematic measurement and reporting of CNS outcomes in clinical trials. This review and meta-analysis found that 77% of eligible trials did not measure or report CNS outcomes. Dizziness was the most commonly reported side effect, with confusion reported in less than 1% of cases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options.

Author: GangulyAnirban, TyagiShachi, ChermanskyChristopher, KanaiAnthony, BeckelJonathan, HashimotoMamoru, ChoKang Jun, ChancellorMichael, KaufmanJonathan, YoshimuraNaoki, TyagiPradeep

Lower urinary tract symptoms treatment
Adverse drug reactions

This article focuses on the diagnosis and treatment of lower urinary tract symptoms in older adults. The challenges include neurodegenerative changes in the micturition reflex, age-related decline in liver and kidney function, and increased risk of adverse drug reactions. This article highlights the benefits of intravesical antimuscarinics over oral antimuscarinics in managing these symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

Cognitive Effects of Anticholinergic Load in Women with Overactive Bladder.

Author: AraklitisGeorge, RobinsonDudley, CardozoLinda

OAB treatment
Cognitive side effects
Mortality risk

Anticholinergic drugs are commonly used to treat overactive bladder syndrome (OAB), but they can have cognitive side effects. This article discusses the importance of considering the anticholinergic load in elderly patients with OAB and explores alternative treatment options like trospium chloride, mirabegron, and conservative therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

Effectiveness of Solifenacin and Trospium for Managing of Severe Symptoms of Overactive Bladder in Patients With Benign Prostatic Hyperplasia.

Author: KosilovKirill Vladimirovich, LoparevSergay A, IvanovskayaMarina A, KosilovaLiliya V

Overactive bladder treatment

Combining trospium and solifenacin is an effective and safe way to manage severe symptoms of overactive bladder in patients with benign prostatic hyperplasia who are taking tamsulosin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Treatments for overactive bladder: focus on pharmacotherapy.

Author: GeoffrionRoxana,

Improved bladder function
Anticholinergic side effects

Anticholinergic drugs are the mainstay of pharmacotherapy for overactive bladder syndrome, but the evidence for their efficacy is mostly derived from short-term studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.

Language : English

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