Paper Details

  1. Home
  2. Paper Details

[Effects of doxazosin enantiomers on alpha-adrenoceptors of isolated rabbit blood vessels].

Author: DuanLi-hua, LiuLi-fang, LuHai-gang, RenLei-ming, ZhangXiao-yuan, ZhaoQing-hua

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effects of R-doxazosin and S-doxazosin on alpha1-adrenoceptor-regulated vasoconstriction in isolated rabbit arteries. The study found that both R-doxazosin and S-doxazosin competitively inhibited vasoconstriction induced by noradrenaline, with R-doxazosin being significantly more potent than S-doxazosin. Neither isomer affected presynaptic alpha2-adrenoceptor-regulated purinergic vasoconstriction at the concentrations studied.
Paper Details　
Original Abstract of the Article :
Doxazosin, a high selective alpha1-adrenoceptor antagonist, is considered as the first-line therapy for the patients with benign prostatic hyperplasia (BPH) and also produce several side effects in cardiovascular system. In this study, we observed the isometric vasoconstrictive responses of the rabb...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/17518041

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2008-07-17
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

17518041

DOI: Digital Object Identifier

17518041

Related Literature

Article Analysis
・Side Effects of doxazosin
SNS
PICO Info
in preparation
Languages

Chinese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.