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Risk of acute liver injury associated with the use of drugs: a multicentre population survey.

Author: ButiM, CastelloteJ, FornéM, GuarnerC, IbáñezL, LaporteJ-R, MasA, PérezE, RigauJ, SabatéM, SolàR, VidalX, XiolX

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Isoniazid, pyrazinamide, rifampicin, amoxicillin with clavulanic acid, erythromicin, chlorpromazine, nimesulide, and ticlopidine presented the highest risk of acute liver injury (point relative risk > 25). Amoxicillin, metoclopramide, captopril and enalapril, furosemide, hydrochlorothiazide, fluoxetine, paroxetine, diazepam, alprazolam, lorazepam, metamizole, low-dose acetylsalicylic acid and salbutamol showed the lowest risk (point relative risk < 5).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Acute liver injury of uncertain aetiology is often drug related and quantitative information about the associated risk is scarce. AIM: To estimate the risk of acute liver injury associated with the use of drugs. METHODS: In a population survey study, 126 cases of acute liver injury wer...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2007.03338.x

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Drug-Induced Liver Injury

Drug-induced liver injury (DILI) is a serious condition that can feel like a sandstorm swirling within the body, damaging the liver and causing a range of symptoms. The researchers in this study aimed to map the landscape of DILI, identifying specific drugs that posed the highest risk to the liver, like identifying treacherous dunes in the vast desert.

A Comprehensive Landscape of Drug-Induced Liver Injury

The study found that certain drugs, such as isoniazid, pyrazinamide, rifampicin, and amoxicillin with clavulanic acid, carried a significantly higher risk of DILI. This knowledge is crucial for healthcare professionals, like skilled desert guides, to help patients navigate the potential risks associated with these drugs.

Weighing the Benefits and Risks

This research underscores the importance of carefully weighing the potential benefits and risks of any medication, particularly those that may affect the liver. It's essential to be aware of the potential dangers, like hidden traps in the desert, and to have open communication with your doctor about any concerns.

Dr.Camel's Conclusion

The desert of medication is vast and complex, with each drug carrying its own unique set of risks and rewards. This study sheds light on the potential dangers of DILI, emphasizing the importance of vigilance and open communication with healthcare providers to navigate this challenging terrain.

Date :
  1. Date Completed 2007-11-06
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

17539979

DOI: Digital Object Identifier

10.1111/j.1365-2036.2007.03338.x

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English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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